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Experimental Therapeutics

Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis

Christine M. Johnson, Rajesh Pandey, Sadhna Sharma, G. K. Khuller, Randall J. Basaraba, Ian M. Orme, Anne J. Lenaerts
Christine M. Johnson
1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523
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  • For correspondence: christine.johnson@colostate.edu
Rajesh Pandey
2Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh-160 012, India
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Sadhna Sharma
2Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh-160 012, India
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G. K. Khuller
2Department of Biochemistry, Postgraduate Institute of Medical Education & Research, Chandigarh-160 012, India
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Randall J. Basaraba
1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523
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Ian M. Orme
1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523
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Anne J. Lenaerts
1Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523
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DOI: 10.1128/AAC.49.10.4335-4338.2005
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ABSTRACT

We evaluated the efficacy of nanoparticle-encapsulated antituberculosis drugs administered every 10 days versus that of daily nonencapsulated drugs against Mycobacterium tuberculosis aerosol infection in guinea pigs. Both treatments significantly reduced the bacterial count and lung histopathology, suggesting that the nanoparticle drug delivery system has potential in intermitted treatment of tuberculosis.

  • Copyright © 2005 American Society for Microbiology
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Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis
Christine M. Johnson, Rajesh Pandey, Sadhna Sharma, G. K. Khuller, Randall J. Basaraba, Ian M. Orme, Anne J. Lenaerts
Antimicrobial Agents and Chemotherapy Sep 2005, 49 (10) 4335-4338; DOI: 10.1128/AAC.49.10.4335-4338.2005

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Oral Therapy Using Nanoparticle-Encapsulated Antituberculosis Drugs in Guinea Pigs Infected with Mycobacterium tuberculosis
Christine M. Johnson, Rajesh Pandey, Sadhna Sharma, G. K. Khuller, Randall J. Basaraba, Ian M. Orme, Anne J. Lenaerts
Antimicrobial Agents and Chemotherapy Sep 2005, 49 (10) 4335-4338; DOI: 10.1128/AAC.49.10.4335-4338.2005
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KEYWORDS

antitubercular agents
Mycobacterium tuberculosis
Nanostructures
tuberculosis

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