In Vitro Susceptibility of Mycobacterium tuberculosis Clinical Isolates to Garenoxacin and DA-7867

Lucio Vera-Cabrera; Jorge Castro-Garza; Adrian Rendon; Jorge Ocampo-Candiani; Oliverio Welsh; Sung Hak Choi; Kym Blackwood; Carmen Molina-Torres

doi:10.1128/AAC.49.10.4351-4353.2005

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In Vitro Susceptibility of Mycobacterium tuberculosis Clinical Isolates to Garenoxacin and DA-7867

Lucio Vera-Cabrera, Jorge Castro-Garza, Adrian Rendon, Jorge Ocampo-Candiani, Oliverio Welsh, Sung Hak Choi, Kym Blackwood, Carmen Molina-Torres

Lucio Vera-Cabrera

1Servicio de Dermatología, Hospital Universitario “José E. González,” Monterrey, N. L., México 64460

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For correspondence: luvera_99@yahoo.com

Jorge Castro-Garza

2División de Biología Celular y Molecular, Centro de Investigación Biomédica del Noreste, IMSS, Monterrey, N. L., México

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Adrian Rendon

3Servicio de Neumología, Hospital Universitario “José E. González,” Monterrey, N. L., México 64460

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Jorge Ocampo-Candiani

1Servicio de Dermatología, Hospital Universitario “José E. González,” Monterrey, N. L., México 64460

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Oliverio Welsh

1Servicio de Dermatología, Hospital Universitario “José E. González,” Monterrey, N. L., México 64460

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Sung Hak Choi

4Research Laboratory, Dong-A Pharmaceutical Co., Ltd., Yongin, Korea

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Kym Blackwood

5National Microbiology Laboratory, Health Canada Canadian Science Centre for Human and Animal Health, Winnipeg, Canada

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Carmen Molina-Torres

1Servicio de Dermatología, Hospital Universitario “José E. González,” Monterrey, N. L., México 64460

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DOI: 10.1128/AAC.49.10.4351-4353.2005

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ABSTRACT

The in vitro activities of DA-7867, a novel oxazolidinone, and garenoxacin (BMS-284756) were compared to those of linezolid in 67 susceptible and drug-resistant clinical isolates of Mycobacterium tuberculosis. DA-7867 was the most active drug with an MIC₉₀ of 0.125 μg/ml, compared to the MIC₉₀s of 4 μg/ml of garenoxacin and 2 μg/ml of linezolid.

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In Vitro Susceptibility of Mycobacterium tuberculosis Clinical Isolates to Garenoxacin and DA-7867

Lucio Vera-Cabrera, Jorge Castro-Garza, Adrian Rendon, Jorge Ocampo-Candiani, Oliverio Welsh, Sung Hak Choi, Kym Blackwood, Carmen Molina-Torres

Antimicrobial Agents and Chemotherapy Sep 2005, 49 (10) 4351-4353; DOI: 10.1128/AAC.49.10.4351-4353.2005

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In Vitro Susceptibility of Mycobacterium tuberculosis Clinical Isolates to Garenoxacin and DA-7867

Lucio Vera-Cabrera, Jorge Castro-Garza, Adrian Rendon, Jorge Ocampo-Candiani, Oliverio Welsh, Sung Hak Choi, Kym Blackwood, Carmen Molina-Torres

Antimicrobial Agents and Chemotherapy Sep 2005, 49 (10) 4351-4353; DOI: 10.1128/AAC.49.10.4351-4353.2005

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KEYWORDS

antitubercular agents

Drug Resistance, Bacterial

fluoroquinolones

Mycobacterium tuberculosis

oxazolidinones

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In Vitro Susceptibility of Mycobacterium tuberculosis Clinical Isolates to Garenoxacin and DA-7867

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