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Mechanisms of Resistance

Influence of Transcriptional Activator RamA on Expression of Multidrug Efflux Pump AcrAB and Tigecycline Susceptibility in Klebsiella pneumoniae

Alexey Ruzin, Melissa A. Visalli, David Keeney, Patricia A. Bradford
Alexey Ruzin
1Wyeth Research, Pearl River, New York
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  • For correspondence: ruzina@wyeth.com
Melissa A. Visalli
1Wyeth Research, Pearl River, New York
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David Keeney
1Wyeth Research, Pearl River, New York
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Patricia A. Bradford
1Wyeth Research, Pearl River, New York
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DOI: 10.1128/AAC.49.3.1017-1022.2005
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Article Information

DOI 
https://doi.org/10.1128/AAC.49.3.1017-1022.2005
PubMed 
15728897

Published By 
American Society for Microbiology Journals
History 
  • Received June 4, 2004
  • Returned for modification August 28, 2004
  • Accepted November 3, 2004
  • Published online February 23, 2005.

Copyright & Usage 
Copyright © 2005 American Society for Microbiology

Author Information

  1. Alexey Ruzin1*,
  2. Melissa A. Visalli1†‡,
  3. David Keeney1† and
  4. Patricia A. Bradford1
  1. 1Wyeth Research, Pearl River, New York
  • ↵* Corresponding author. Mailing address: Wyeth Research, Department of Infectious Disease, 401 North Middletown Rd., Bldg. 200, Rm. 3219, Pearl River, NY 10965. Phone: (845) 602-4592. Fax: (845) 602-5671. E-mail: ruzina{at}wyeth.com .
  • ↵† M.A.V. and D.K. contributed equally to the present study.

  • ↵‡ Present address: Fort Wayne, Ind.

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Influence of Transcriptional Activator RamA on Expression of Multidrug Efflux Pump AcrAB and Tigecycline Susceptibility in Klebsiella pneumoniae
Alexey Ruzin, Melissa A. Visalli, David Keeney, Patricia A. Bradford
Antimicrobial Agents and Chemotherapy Feb 2005, 49 (3) 1017-1022; DOI: 10.1128/AAC.49.3.1017-1022.2005

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Influence of Transcriptional Activator RamA on Expression of Multidrug Efflux Pump AcrAB and Tigecycline Susceptibility in Klebsiella pneumoniae
Alexey Ruzin, Melissa A. Visalli, David Keeney, Patricia A. Bradford
Antimicrobial Agents and Chemotherapy Feb 2005, 49 (3) 1017-1022; DOI: 10.1128/AAC.49.3.1017-1022.2005
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KEYWORDS

Bacterial Proteins
Klebsiella pneumoniae
Membrane Transport Proteins
minocycline

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