In Vitro and Intracellular Activities of LBM415 (NVP PDF-713) against Legionella pneumophila

ABSTRACT

LBM415 activity against extracellular and intracellular Legionella pneumophila was studied. The LBM415 MIC₅₀ for 20 Legionella sp. strains was 4 μg/ml, versus 0.06, 0.25, and ≤ 0.03 μg/ml for azithromycin, erythromycin, and levofloxacin, respectively. LBM415 (0.5 and 16 μg/ml) reversibly prevented intracellular growth of two L. pneumophila strains and was less active than erythromycin.