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Mechanisms of Resistance

Integron-Encoded GES-Type Extended-Spectrum β-Lactamase with Increased Activity toward Aztreonam in Pseudomonas aeruginosa

Laurent Poirel, Laura Brinas, Nicolas Fortineau, Patrice Nordmann
Laurent Poirel
1Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 K.-Bicêtre, France
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Laura Brinas
1Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 K.-Bicêtre, France
2Area de Bioquimica y Biologia Molecular, Universidad de La Rioja, 26006 Logrono, Spain
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Nicolas Fortineau
1Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 K.-Bicêtre, France
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Patrice Nordmann
1Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 K.-Bicêtre, France
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  • For correspondence: nordmann.patrice@bct.ap-hop-paris.fr
DOI: 10.1128/AAC.49.8.3593-3597.2005
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Article Information

DOI 
https://doi.org/10.1128/AAC.49.8.3593-3597.2005
PubMed 
16048994

Published By 
American Society for Microbiology Journals
History 
  • Received February 15, 2005
  • Returned for modification March 22, 2005
  • Accepted May 4, 2005
  • Published online July 26, 2005.

Copyright & Usage 
Copyright © 2005 American Society for Microbiology

Author Information

  1. Laurent Poirel1,
  2. Laura Brinas1,2,
  3. Nicolas Fortineau1 and
  4. Patrice Nordmann1*
  1. 1Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, Université Paris XI, 94275 K.-Bicêtre, France
  2. 2Area de Bioquimica y Biologia Molecular, Universidad de La Rioja, 26006 Logrono, Spain
  • ↵* Corresponding author. Mailing address: Service de Bactériologie-Virologie, Hôpital de Bicêtre, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre cedex, France. Phone: 33-1-45-21-36-32. Fax: 33-1-45-21-63-40. E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr .

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Integron-Encoded GES-Type Extended-Spectrum β-Lactamase with Increased Activity toward Aztreonam in Pseudomonas aeruginosa
Laurent Poirel, Laura Brinas, Nicolas Fortineau, Patrice Nordmann
Antimicrobial Agents and Chemotherapy Jul 2005, 49 (8) 3593-3597; DOI: 10.1128/AAC.49.8.3593-3597.2005

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Integron-Encoded GES-Type Extended-Spectrum β-Lactamase with Increased Activity toward Aztreonam in Pseudomonas aeruginosa
Laurent Poirel, Laura Brinas, Nicolas Fortineau, Patrice Nordmann
Antimicrobial Agents and Chemotherapy Jul 2005, 49 (8) 3593-3597; DOI: 10.1128/AAC.49.8.3593-3597.2005
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KEYWORDS

Anti-Bacterial Agents
aztreonam
integrons
Pseudomonas aeruginosa
beta-lactam resistance
beta-lactamases

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