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Mechanisms of Resistance

Inactivation of Sterol Δ5,6-Desaturase Attenuates Virulence in Candida albicans

Andrew S. Chau, Maya Gurnani, Robyn Hawkinson, Michel Laverdiere, Anthony Cacciapuoti, Paul M. McNicholas
Andrew S. Chau
1Schering Plough Research Institute, 2015 Galloping Hill Road, K15-4-4700, Kenilworth, New Jersey 07033
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Maya Gurnani
1Schering Plough Research Institute, 2015 Galloping Hill Road, K15-4-4700, Kenilworth, New Jersey 07033
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Robyn Hawkinson
1Schering Plough Research Institute, 2015 Galloping Hill Road, K15-4-4700, Kenilworth, New Jersey 07033
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Michel Laverdiere
2Department of Microbiology-Infectious Diseases, Hospital Maisonneuve-Rosemont, Montreal, Quebec, Canada
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Anthony Cacciapuoti
1Schering Plough Research Institute, 2015 Galloping Hill Road, K15-4-4700, Kenilworth, New Jersey 07033
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Paul M. McNicholas
1Schering Plough Research Institute, 2015 Galloping Hill Road, K15-4-4700, Kenilworth, New Jersey 07033
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  • For correspondence: paul.mcnicholas@spcorp.com
DOI: 10.1128/AAC.49.9.3646-3651.2005
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Article Information

DOI 
https://doi.org/10.1128/AAC.49.9.3646-3651.2005
PubMed 
16127034

Published By 
American Society for Microbiology Journals
History 
  • Received April 12, 2005
  • Returned for modification May 11, 2005
  • Accepted May 26, 2005
  • Published online August 26, 2005.

Copyright & Usage 
Copyright © 2005 American Society for Microbiology

Author Information

  1. Andrew S. Chau1,
  2. Maya Gurnani1,
  3. Robyn Hawkinson1,
  4. Michel Laverdiere2,
  5. Anthony Cacciapuoti1 and
  6. Paul M. McNicholas1*
  1. 1Schering Plough Research Institute, 2015 Galloping Hill Road, K15-4-4700, Kenilworth, New Jersey 07033
  2. 2Department of Microbiology-Infectious Diseases, Hospital Maisonneuve-Rosemont, Montreal, Quebec, Canada
  • ↵* Corresponding author. Mailing address: Schering Plough Research Institute, K15-4-4700, 2015 Galloping Hill Road, Kenilworth, NJ 07033. Phone: (908) 740-7644. Fax: (908) 740-3918. E-mail: paul.mcnicholas{at}spcorp.com .
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Inactivation of Sterol Δ5,6-Desaturase Attenuates Virulence in Candida albicans
Andrew S. Chau, Maya Gurnani, Robyn Hawkinson, Michel Laverdiere, Anthony Cacciapuoti, Paul M. McNicholas
Antimicrobial Agents and Chemotherapy Aug 2005, 49 (9) 3646-3651; DOI: 10.1128/AAC.49.9.3646-3651.2005

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Inactivation of Sterol Δ5,6-Desaturase Attenuates Virulence in Candida albicans
Andrew S. Chau, Maya Gurnani, Robyn Hawkinson, Michel Laverdiere, Anthony Cacciapuoti, Paul M. McNicholas
Antimicrobial Agents and Chemotherapy Aug 2005, 49 (9) 3646-3651; DOI: 10.1128/AAC.49.9.3646-3651.2005
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KEYWORDS

Candida albicans
Enzyme Inhibitors
Oxidoreductases

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