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Mechanisms of Resistance

Quinolone Efflux Pumps Play a Central Role in Emergence of Fluoroquinolone Resistance in Streptococcus pneumoniae

Nelson L. Jumbe, Arnold Louie, Michael H. Miller, Weiguo Liu, Mark R. Deziel, Vincent H. Tam, Reetu Bachhawat, George L. Drusano
Nelson L. Jumbe
1Ordway Research Institute, Albany, New York
2Center for Immunology and Microbial Diseases, Albany Medical College, Albany, New York
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Arnold Louie
1Ordway Research Institute, Albany, New York
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Michael H. Miller
2Center for Immunology and Microbial Diseases, Albany Medical College, Albany, New York
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Weiguo Liu
1Ordway Research Institute, Albany, New York
2Center for Immunology and Microbial Diseases, Albany Medical College, Albany, New York
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Mark R. Deziel
1Ordway Research Institute, Albany, New York
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Vincent H. Tam
1Ordway Research Institute, Albany, New York
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Reetu Bachhawat
2Center for Immunology and Microbial Diseases, Albany Medical College, Albany, New York
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George L. Drusano
1Ordway Research Institute, Albany, New York
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  • For correspondence: gdrusano@ordwayresearch.org
DOI: 10.1128/AAC.50.1.310-317.2006
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Article Information

DOI 
https://doi.org/10.1128/AAC.50.1.310-317.2006
PubMed 
16377702

Published By 
American Society for Microbiology Journals
History 
  • Received June 18, 2005
  • Returned for modification August 14, 2005
  • Accepted September 29, 2005
  • Published online December 23, 2005.

Copyright & Usage 
Copyright © 2006 American Society for Microbiology

Author Information

  1. Nelson L. Jumbe1,2,
  2. Arnold Louie1,
  3. Michael H. Miller2,
  4. Weiguo Liu1,2,
  5. Mark R. Deziel1,
  6. Vincent H. Tam1,
  7. Reetu Bachhawat2 and
  8. George L. Drusano1*
  1. 1Ordway Research Institute, Albany, New York
  2. 2Center for Immunology and Microbial Diseases, Albany Medical College, Albany, New York
  • ↵* Corresponding author. Mailing address: Ordway Research Institute, 150 New Scotland Avenue, Albany, NY 12208. Phone: (518) 641-6434. E-mail: gdrusano{at}ordwayresearch.org .
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Quinolone Efflux Pumps Play a Central Role in Emergence of Fluoroquinolone Resistance in Streptococcus pneumoniae
Nelson L. Jumbe, Arnold Louie, Michael H. Miller, Weiguo Liu, Mark R. Deziel, Vincent H. Tam, Reetu Bachhawat, George L. Drusano
Antimicrobial Agents and Chemotherapy Dec 2005, 50 (1) 310-317; DOI: 10.1128/AAC.50.1.310-317.2006

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Quinolone Efflux Pumps Play a Central Role in Emergence of Fluoroquinolone Resistance in Streptococcus pneumoniae
Nelson L. Jumbe, Arnold Louie, Michael H. Miller, Weiguo Liu, Mark R. Deziel, Vincent H. Tam, Reetu Bachhawat, George L. Drusano
Antimicrobial Agents and Chemotherapy Dec 2005, 50 (1) 310-317; DOI: 10.1128/AAC.50.1.310-317.2006
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KEYWORDS

anti-infective agents
Carrier Proteins
Drug Resistance, Bacterial
fluoroquinolones
Streptococcus pneumoniae

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