DOI: 10.1128/AAC.50.2.819-821.2006
Article Figures & Data
Tables
- TABLE 1.
Percent susceptible, intermediate, and resistant (CLSI breakpoints) for doripenem versus P. aeruginosa and B. cepaciaa
Organism Antimicrobial MIC50 MIC90 Minimum Maximum Geometric mean Mode % S % I % R All strains (n = 194) Doripenem 0.25 8 0.25 256 0.59 0.25 NA NA NA Imipenem 1 16 0.25 256 1.37 1 83.00 4.60 12.40 Levofloxacin 1 8 0.25 128 1.43 0.5 69.10 10.80 20.10 Piperacillin 8 128 0.25 >512 9.43 4 SS SS SS Ceftazidime 2 16 0.25 >512 2.98 2 88.70 3.60 7.70 Aztreonam 8 64 0.25 >512 7.19 8 66.0 12.40 21.60 Tobramycin 1 64 0.25 >512 1.78 0.5 78.90 1.00 20.10 Cefepime 4 32 0.25 256 4.1 2 78.90 9.80 11.30 B. cepacia (n = 34) Doripenem 2 8 0.25 128 2.35 8 NA NA NA Imipenem 4 16 0.25 128 3.69 16 50.00 20.60 29.40 Levofloxacin 1 8 0.25 8 1.2 0.25 76.50 11.80 11.80 Piperacillin 32 128 2 >512 19.22 2 41.20 38.20 20.60 Ceftazidime 4 16 0.25 >512 2.83 4 82.40 14.70 2.90 Aztreonam 32 256 0.25 512 21.72 64 29.40 14.70 55.90 Tobramycin 64 128 0.25 256 18.45 64 23.50 0.00 76.50 Cefepime 16 128 0.25 256 8.68 0.25 47.10 14.70 38.20 P. aeruginosa (CF isolates; n = 82) Doripenem 0.25 2 0.25 256 0.52 0.25 NA NA NA Imipenem 1 16 0.25 256 1.28 1 86.60 1.20 12.20 Levofloxacin 1 16 0.25 128 1.75 0.5 63.40 11.00 25.60 Piperacillin 8 256 0.25 >512 10.85 4 86.60 NA 13.40 Ceftazidime 2 32 0.25 256 3.47 2 84.10 2.40 13.40 Aztreonam 8 64 0.25 >512 7.8 8 63.40 14.60 22.00 Tobramycin 0.5 8 0.25 512 1.04 0.5 89.00 2.40 8.50 Cefepime 2 16 0.25 64 3.52 2 84.10 7.30 8.50 P. aeruginosa (non-CF isolates; n = 78) Doripenem 0.25 1 0.25 16 0.36 0.25 NA NA NA Imipenem 1 2 0.25 32 0.95 1 93.60 1.30 5.10 Levofloxacin 1 8 0.25 64 1.25 0.5 71.80 10.30 17.90 Piperacillin 8 16 0.25 512 5.97 4 96.20 NA 3.80 Ceftazidime 2 8 0.25 64 2.61 2 96.20 0.00 3.80 Aztreonam 8 16 0.25 64 4.07 8 84.60 9.00 6.40 Tobramycin 1 2 0.25 >512 0.97 0.5 92.30 0.00 7.70 Cefepime 2 16 0.25 32 3.47 2 87.20 10.30 2.60 ↵ a Abbreviations: S, susceptible; I, intermediate; R, resistant; NA, not applicable (no approved ranges); SS, species specific. MIC50, MIC90, minimum, maximum, geometric mean, and mode are all in micrograms per milliliter.
- TABLE 2.
Doripenem versus imipenem-resistant and -intermediate P. aeruginosa isolatesa
Strain no. Isolate type Doripenem MIC Imipenem MIC, I or R N1873 CF isolate 4 16R N2408 CF isolate 2 16R N3794 CF isolate 4 16R N4082 CF isolate 2 16R N6687 CF isolate 1 16R N7086 Non-CF isolate 1 16R N7087 Non-CF isolate 2 16R N4972 CF isolate 2 8I N7982 Non-CF isolate 4 8I N3791 CF isolate 16 64R N4077 CF isolate 8 16R N4079 CF isolate 256 256R N5395 CF isolate 16 16R N6693 CF isolate 16 16R N7093 Non-CF isolate 16 32R N7095 Non-CF isolate 16 16R ↵ a MICs are in micrograms per milliliter. I, intermediate; R, resistant.
