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Mechanisms of Resistance

Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus

Longzhu Cui, Eiji Tominaga, Hui-min Neoh, Keiichi Hiramatsu
Longzhu Cui
1Department of Bacteriology
2Department of Infection Control Science, Juntendo University, 2-1-1 Bunkyo-Ku, Tokyo, Japan 113-8421
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  • For correspondence: longzhu@med.juntendo.ac.jp
Eiji Tominaga
2Department of Infection Control Science, Juntendo University, 2-1-1 Bunkyo-Ku, Tokyo, Japan 113-8421
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Hui-min Neoh
1Department of Bacteriology
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Keiichi Hiramatsu
1Department of Bacteriology
2Department of Infection Control Science, Juntendo University, 2-1-1 Bunkyo-Ku, Tokyo, Japan 113-8421
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DOI: 10.1128/AAC.50.3.1079-1082.2006
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ABSTRACT

We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus (VISA). This correlation is related to cell wall thickening, suggesting that, similar to the case with vancomycin resistance in VISA, the physical barrier of a thickened cell wall may contribute to daptomycin resistance in S. aureus.

  • Copyright © 2006 American Society for Microbiology
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Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus
Longzhu Cui, Eiji Tominaga, Hui-min Neoh, Keiichi Hiramatsu
Antimicrobial Agents and Chemotherapy Feb 2006, 50 (3) 1079-1082; DOI: 10.1128/AAC.50.3.1079-1082.2006

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Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus
Longzhu Cui, Eiji Tominaga, Hui-min Neoh, Keiichi Hiramatsu
Antimicrobial Agents and Chemotherapy Feb 2006, 50 (3) 1079-1082; DOI: 10.1128/AAC.50.3.1079-1082.2006
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KEYWORDS

Anti-Bacterial Agents
daptomycin
Staphylococcus aureus
vancomycin
vancomycin resistance

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