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Mechanisms of Resistance

Prevalence of First-Step Mutants among Levofloxacin-Susceptible Invasive Isolates of Streptococcus pneumoniae in the United States

Mathias W. R. Pletz, Ardaman P. Shergill, Lesley McGee, Bernard Beall, Cynthia G. Whitney, Keith P. Klugman, ; for the Active Bacterial Core Surveillance Team
Mathias W. R. Pletz
1Hubert Department of Global Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia
2Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany
3Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
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  • For correspondence: Pletz.Mathias@mh-hannover.de
Ardaman P. Shergill
1Hubert Department of Global Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia
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Lesley McGee
1Hubert Department of Global Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia
3Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
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Bernard Beall
3Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
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Cynthia G. Whitney
3Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
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Keith P. Klugman
1Hubert Department of Global Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia
3Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
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3Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
DOI: 10.1128/AAC.50.4.1561-1563.2006
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ABSTRACT

By use of a PCR-restriction fragment length polymorphism assay, we screened 496 levofloxacin-susceptible invasive pneumococcal strains (MIC ≤ 2 mg/liter) for quinolone resistance-determining region mutations known to confer fluoroquinolone resistance. Among those with a levofloxacin MIC of 2 mg/liter, 16.2% of isolates recovered from nursing home residents and 6.4% from non-nursing home residents had first-step mutations.

  • Copyright © 2006 American Society for Microbiology
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Prevalence of First-Step Mutants among Levofloxacin-Susceptible Invasive Isolates of Streptococcus pneumoniae in the United States
Mathias W. R. Pletz, Ardaman P. Shergill, Lesley McGee, Bernard Beall, Cynthia G. Whitney, Keith P. Klugman for the Active Bacterial Core Surveillance Team
Antimicrobial Agents and Chemotherapy Mar 2006, 50 (4) 1561-1563; DOI: 10.1128/AAC.50.4.1561-1563.2006

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Prevalence of First-Step Mutants among Levofloxacin-Susceptible Invasive Isolates of Streptococcus pneumoniae in the United States
Mathias W. R. Pletz, Ardaman P. Shergill, Lesley McGee, Bernard Beall, Cynthia G. Whitney, Keith P. Klugman for the Active Bacterial Core Surveillance Team
Antimicrobial Agents and Chemotherapy Mar 2006, 50 (4) 1561-1563; DOI: 10.1128/AAC.50.4.1561-1563.2006
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KEYWORDS

Anti-Bacterial Agents
levofloxacin
mutation
ofloxacin
Streptococcus pneumoniae

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