Article Figures & Data
Figures
- FIG. 1.
(a) Structures of colistin A and B; (b) structures of sodium colistin A and B methanesulfonate (CMS). Fatty acid, 6-methyloctanoic acid for colistin A and 6-methylheptanoic acid for colistin B; Thr, threonine; Leu, leucine; Dab, α,γ-diaminobutyric acid. α and γ indicate the respective —NH2 involved in the peptide linkage.
- FIG. 2.
(a) Concentration-time course of colistin produced from CMS spiked at 8.0 mg/liter and 32 mg/liter (n = 3) and from incremental spiking with colistin (n = 3); (b) time-kill curves for P. aeruginosa obtained by using colistin methanesulfonate spiked at 8.0 mg/liter and 32 mg/liter (n = 3) at zero time, spiked incrementally with colistin to mimic the colistin concentration-time course achieved after spiking of the sample with colistin methanesulfonate at 8.0 mg/liter and 32 mg/liter (n = 3), and colistin spiked at 6.0 mg/liter at zero time (n = 1; control experiment).
Tables
- TABLE 1.
AUC0-240 of killing curves normalized by baseline log10 CFU/mlt = 0
Colistin form AUC0-240/(log10 CFU/mlt = 0) (n = 3) 8.0 mg/liter 32 mg/liter CMS 186.3 ± 6.0 90.4 ± 4.1 Colistina 192.8 ± 10.4 70.0 ± 7.4 ↵a Spiked incrementally to achieve the same concentration-time course of colistin observed from hydrolysis of CMS spiked initially at 8.0 mg/liter or 32 mg/liter.
