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In Vitro Activities of Posaconazole, Fluconazole, Itraconazole, Voriconazole, and Amphotericin B against a Large Collection of Clinically Important Molds and Yeasts

F. Sabatelli, R. Patel, P. A. Mann, C. A. Mendrick, C. C. Norris, R. Hare, D. Loebenberg, T. A. Black, P. M. McNicholas
F. Sabatelli
Schering-Plough Research Institute, Kenilworth, New Jersey
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R. Patel
Schering-Plough Research Institute, Kenilworth, New Jersey
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P. A. Mann
Schering-Plough Research Institute, Kenilworth, New Jersey
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C. A. Mendrick
Schering-Plough Research Institute, Kenilworth, New Jersey
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C. C. Norris
Schering-Plough Research Institute, Kenilworth, New Jersey
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R. Hare
Schering-Plough Research Institute, Kenilworth, New Jersey
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D. Loebenberg
Schering-Plough Research Institute, Kenilworth, New Jersey
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T. A. Black
Schering-Plough Research Institute, Kenilworth, New Jersey
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P. M. McNicholas
Schering-Plough Research Institute, Kenilworth, New Jersey
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  • For correspondence: paul.mcnicholas@spcorp.com
DOI: 10.1128/AAC.00163-06
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ABSTRACT

The in vitro activity of the novel triazole antifungal agent posaconazole (Noxafil; SCH 56592) was assessed in 45 laboratories against approximately 19,000 clinically important strains of yeasts and molds. The activity of posaconazole was compared with those of itraconazole, fluconazole, voriconazole, and amphotericin B against subsets of the isolates. Strains were tested utilizing Clinical and Laboratory Standards Institute broth microdilution methods using RPMI 1640 medium (except for amphotericin B, which was frequently tested in antibiotic medium 3). MICs were determined at the recommended endpoints and time intervals. Against all fungi in the database (22,850 MICs), the MIC50 and MIC90 values for posaconazole were 0.063 μg/ml and 1 μg/ml, respectively. MIC90 values against all yeasts (18,351 MICs) and molds (4,499 MICs) were both 1 μg/ml. In comparative studies against subsets of the isolates, posaconazole was more active than, or within 1 dilution of, the comparator drugs itraconazole, fluconazole, voriconazole, and amphotericin B against approximately 7,000 isolates of Candida and Cryptococcus spp. Against all molds (1,702 MICs, including 1,423 MICs for Aspergillus isolates), posaconazole was more active than or equal to the comparator drugs in almost every category. Posaconazole was active against isolates of Candida and Aspergillus spp. that exhibit resistance to fluconazole, voriconazole, and amphotericin B and was much more active than the other triazoles against zygomycetes. Posaconazole exhibited potent antifungal activity against a wide variety of clinically important fungal pathogens and was frequently more active than other azoles and amphotericin B.

  • Copyright © 2006 American Society for Microbiology
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In Vitro Activities of Posaconazole, Fluconazole, Itraconazole, Voriconazole, and Amphotericin B against a Large Collection of Clinically Important Molds and Yeasts
F. Sabatelli, R. Patel, P. A. Mann, C. A. Mendrick, C. C. Norris, R. Hare, D. Loebenberg, T. A. Black, P. M. McNicholas
Antimicrobial Agents and Chemotherapy May 2006, 50 (6) 2009-2015; DOI: 10.1128/AAC.00163-06

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In Vitro Activities of Posaconazole, Fluconazole, Itraconazole, Voriconazole, and Amphotericin B against a Large Collection of Clinically Important Molds and Yeasts
F. Sabatelli, R. Patel, P. A. Mann, C. A. Mendrick, C. C. Norris, R. Hare, D. Loebenberg, T. A. Black, P. M. McNicholas
Antimicrobial Agents and Chemotherapy May 2006, 50 (6) 2009-2015; DOI: 10.1128/AAC.00163-06
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KEYWORDS

amphotericin B
antifungal agents
Aspergillus
Candida
Cryptococcus

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