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Clinical Therapeutics

Population Pharmacokinetic Assessment of a New Regimen of Mefloquine Used in Combination Treatment of Uncomplicated Falciparum Malaria

Elizabeth A. Ashley, Kasia Stepniewska, Niklas Lindegårdh, Rose McGready, Robert Hutagalung, Rae Hae, Pratap Singhasivanon, Nicholas J. White, François Nosten
Elizabeth A. Ashley
1Shoklo Malaria Research Unit, P.O. Box 46, Mae Sot, Tak 63110, Thailand
2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom
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  • For correspondence: SMRU@tropmedres.ac
Kasia Stepniewska
2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom
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Niklas Lindegårdh
2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom
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Rose McGready
1Shoklo Malaria Research Unit, P.O. Box 46, Mae Sot, Tak 63110, Thailand
2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom
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Robert Hutagalung
1Shoklo Malaria Research Unit, P.O. Box 46, Mae Sot, Tak 63110, Thailand
2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
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Rae Hae
1Shoklo Malaria Research Unit, P.O. Box 46, Mae Sot, Tak 63110, Thailand
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Pratap Singhasivanon
2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
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Nicholas J. White
2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom
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François Nosten
1Shoklo Malaria Research Unit, P.O. Box 46, Mae Sot, Tak 63110, Thailand
2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom
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DOI: 10.1128/AAC.00040-06
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Article Information

DOI 
https://doi.org/10.1128/AAC.00040-06
PubMed 
16801402

Published By 
American Society for Microbiology Journals
History 
  • Received January 10, 2006
  • Returned for modification March 24, 2006
  • Accepted April 21, 2006
  • Published online June 26, 2006.

Copyright & Usage 
Copyright © 2006 American Society for Microbiology

Author Information

  1. Elizabeth A. Ashley1,2,3*,
  2. Kasia Stepniewska2,3,
  3. Niklas Lindegårdh2,3,
  4. Rose McGready1,2,3,
  5. Robert Hutagalung1,2,
  6. Rae Hae1,
  7. Pratap Singhasivanon2,
  8. Nicholas J. White2,3 and
  9. François Nosten1,2,3
  1. 1Shoklo Malaria Research Unit, P.O. Box 46, Mae Sot, Tak 63110, Thailand
  2. 2Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
  3. 3Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Old Road, Headington, Oxford, United Kingdom
  • ↵* Corresponding author. Mailing address: Shoklo Malaria Research Unit, P.O. Box 46, Mae Sot, Tak 63110, Thailand. Phone: 66 55 545 021. Fax: 66 55 545 020. E-mail: SMRU{at}tropmedres.ac .
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Population Pharmacokinetic Assessment of a New Regimen of Mefloquine Used in Combination Treatment of Uncomplicated Falciparum Malaria
Elizabeth A. Ashley, Kasia Stepniewska, Niklas Lindegårdh, Rose McGready, Robert Hutagalung, Rae Hae, Pratap Singhasivanon, Nicholas J. White, François Nosten
Antimicrobial Agents and Chemotherapy Jun 2006, 50 (7) 2281-2285; DOI: 10.1128/AAC.00040-06

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Population Pharmacokinetic Assessment of a New Regimen of Mefloquine Used in Combination Treatment of Uncomplicated Falciparum Malaria
Elizabeth A. Ashley, Kasia Stepniewska, Niklas Lindegårdh, Rose McGready, Robert Hutagalung, Rae Hae, Pratap Singhasivanon, Nicholas J. White, François Nosten
Antimicrobial Agents and Chemotherapy Jun 2006, 50 (7) 2281-2285; DOI: 10.1128/AAC.00040-06
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  • Article
    • ABSTRACT
    • Study site.
    • Ethical review.
    • MATERIALS AND METHODS
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KEYWORDS

antimalarials
Malaria, Falciparum
mefloquine

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