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Experimental Therapeutics

Phage Therapy of Pseudomonas aeruginosa Infection in a Mouse Burn Wound Model

Catherine S. McVay, Marisela Velásquez, Joe A. Fralick
Catherine S. McVay
Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas
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Marisela Velásquez
Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas
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Joe A. Fralick
Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas
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  • For correspondence: joe.fralick@ttmc.ttuhsc.edu
DOI: 10.1128/AAC.01028-06
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    FIG. 1.

    Pharmacokinetics of the phages in noninfected mice. A cocktail containing ∼3 × 108 phage was injected i.p., i.m., or s.c. into uninjured, uninfected mice. Groups of mice (n = 3) were killed at 0.5 h hpi, 12 hpi, 24 hpi, 36 hpi, or 48 hpi. Tissues were removed and the numbers of PFU were determined by serial dilution and plating on PAO1Rif. (A) PFU/gram liver; (B) PFU/gram spleen; (C) PFU/ml blood. Values are means ± standard errors of the means.

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  • TABLE 1.

    Protection studies: efficacy of phage therapy on P. aeruginosa infection of burn wounds

    TreatmentNo. of survivors/total no. of mice (% survival)a
    Expt 1Expt 2Expt 3Combined exptb
    48 hpi72 hpi48 hpi72 hpi48 hpi72 hpi48 hpi72 hpi
    PAO1 only0/6 (0)0/6 (0)1/6 (16.7)0/6 (0)2/6 (33.3)1/6 (16.7)3/18 (17)1/18 (6)
    Phage by i.p. route only6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)18/18 (100)18/18 (100)
    Phage by i.m. route only6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)18/18 (100)18/18 (100)
    Phage by s.c. route only6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)6/6 (100)18/18 (100)18/18 (100)
    Phage by i.p. route + PAO1 infection6/6 (100)5/6 (83.3)6/6 (100)6/6 (100)5/5 (100)4/5 (80)17/17 (100)c15/17 (88)e
    Phage by i.m. route + PAO1 infection3/6 (50)2/6 (33.3)3/6 (50)0/6 (0)4/6 (66.7)3/6 (50)10/18 (56)d5/18 (28)
    Phage by s.c. route + PAO1 infection2/6 (33.3)2/6 (33.3)3/6 (50)0/6 (0)5/6 (83.3)2/6 (33.3)10/18 (56)d4/18 (22)
    • ↵ a The cumulative survival was determined at 48 h and 72 hpi.

    • ↵ b The average percent survival of animals in three experiments determined at 48 and 72 hpi.

    • ↵ c The rate of survival for animals receiving the phage cocktail i.p. was significantly greater (P < 0.0001) than that for untreated infected control animals at the same time period.

    • ↵ d The rate of survival for animals receiving the phage cocktail i.p. was significantly greater (P < 0.01) than that for untreated infected control animals at the same time period.

    • ↵ e The rate of survival for animals receiving the phage cocktail i.p. was significantly greater (P < 0.0026) than that for untreated infected control animals at the same time period.

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Phage Therapy of Pseudomonas aeruginosa Infection in a Mouse Burn Wound Model
Catherine S. McVay, Marisela Velásquez, Joe A. Fralick
Antimicrobial Agents and Chemotherapy May 2007, 51 (6) 1934-1938; DOI: 10.1128/AAC.01028-06

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Phage Therapy of Pseudomonas aeruginosa Infection in a Mouse Burn Wound Model
Catherine S. McVay, Marisela Velásquez, Joe A. Fralick
Antimicrobial Agents and Chemotherapy May 2007, 51 (6) 1934-1938; DOI: 10.1128/AAC.01028-06
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KEYWORDS

burns
Disease Models, Animal
Pseudomonas Infections
Pseudomonas Phages
Pseudomonas aeruginosa
wound infection

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