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Pharmacology

Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice

Xianbin Tian, Jun Li, Maciej J. Zamek-Gliszczynski, Arlene S. Bridges, Peijin Zhang, Nita J. Patel, Thomas J. Raub, Gary M. Pollack, Kim L. R. Brouwer
Xianbin Tian
1School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina
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Jun Li
1School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina
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Maciej J. Zamek-Gliszczynski
1School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina
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Arlene S. Bridges
1School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina
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Peijin Zhang
1School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina
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Nita J. Patel
2Eli Lilly and Company, Drug Disposition, Indianapolis, Indiana
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Thomas J. Raub
2Eli Lilly and Company, Drug Disposition, Indianapolis, Indiana
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Gary M. Pollack
1School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina
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Kim L. R. Brouwer
1School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina
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  • For correspondence: kbrouwer@unc.edu
DOI: 10.1128/AAC.00082-07
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Article Information

DOI 
https://doi.org/10.1128/AAC.00082-07
PubMed 
17576841

Published By 
American Society for Microbiology Journals
History 
  • Received January 19, 2007
  • Returned for modification March 7, 2007
  • Accepted June 7, 2007
  • Published online August 22, 2007.

Copyright & Usage 
Copyright © 2007 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (June 18, 2007).
  • You are viewing the most recent version of this article.

Author Information

  1. Xianbin Tian1†,
  2. Jun Li1,
  3. Maciej J. Zamek-Gliszczynski1‡,
  4. Arlene S. Bridges1,
  5. Peijin Zhang1§,
  6. Nita J. Patel2,
  7. Thomas J. Raub2,
  8. Gary M. Pollack1 and
  9. Kim L. R. Brouwer1*
  1. 1School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina
  2. 2Eli Lilly and Company, Drug Disposition, Indianapolis, Indiana
  • ↵* Corresponding author. Mailing address: Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, C.B. 7360, Kerr Hall, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7360. Phone: (919) 962-7030. Fax: (919) 962-0644. E-mail: kbrouwer{at}unc.edu
  • ↵† Present address: Wyeth, Discovery Pharmacokinetics, Andover, MA.; ‡ Present address: Eli Lilly and Company, Drug Disposition, Indianapolis, IN.; § Present address: MPI Research, Mattawan, MI.

  • ▿ Published ahead of print on 18 June 2007.

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Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice
Xianbin Tian, Jun Li, Maciej J. Zamek-Gliszczynski, Arlene S. Bridges, Peijin Zhang, Nita J. Patel, Thomas J. Raub, Gary M. Pollack, Kim L. R. Brouwer
Antimicrobial Agents and Chemotherapy Aug 2007, 51 (9) 3230-3234; DOI: 10.1128/AAC.00082-07

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Roles of P-Glycoprotein, Bcrp, and Mrp2 in Biliary Excretion of Spiramycin in Mice
Xianbin Tian, Jun Li, Maciej J. Zamek-Gliszczynski, Arlene S. Bridges, Peijin Zhang, Nita J. Patel, Thomas J. Raub, Gary M. Pollack, Kim L. R. Brouwer
Antimicrobial Agents and Chemotherapy Aug 2007, 51 (9) 3230-3234; DOI: 10.1128/AAC.00082-07
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KEYWORDS

ATP Binding Cassette Transporter, Subfamily B
ATP-Binding Cassette Transporters
Bile
Coccidiostats
Membrane Transport Proteins
Multidrug Resistance-Associated Proteins
Spiramycin

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