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Mechanisms of Resistance

Genomic Analysis Reveals a Point Mutation in the Two-Component Sensor Gene graS That Leads to Intermediate Vancomycin Resistance in Clinical Staphylococcus aureus

Benjamin P. Howden, Timothy P. Stinear, David L. Allen, Paul D. R. Johnson, Peter B. Ward, John K. Davies
Benjamin P. Howden
1Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Wellington Rd., Clayton, Victoria, Australia
2Infectious Diseases
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  • For correspondence: Benjamin.Howden@austin.org.au
Timothy P. Stinear
1Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Wellington Rd., Clayton, Victoria, Australia
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David L. Allen
1Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Wellington Rd., Clayton, Victoria, Australia
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Paul D. R. Johnson
2Infectious Diseases
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Peter B. Ward
3Microbiology Departments, Austin Health, Heidelberg, Victoria, Australia
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John K. Davies
1Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Wellington Rd., Clayton, Victoria, Australia
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DOI: 10.1128/AAC.01613-07
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Article Information

DOI 
https://doi.org/10.1128/AAC.01613-07
PubMed 
18644967

Published By 
American Society for Microbiology Journals
History 
  • Received December 17, 2007
  • Returned for modification February 15, 2008
  • Accepted July 3, 2008
  • Published online September 24, 2008.

Copyright & Usage 
Copyright © 2008 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (July 21, 2008).
  • You are viewing the most recent version of this article.

Author Information

  1. Benjamin P. Howden1,2*,
  2. Timothy P. Stinear1,
  3. David L. Allen1,
  4. Paul D. R. Johnson2,
  5. Peter B. Ward3 and
  6. John K. Davies1
  1. 1Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Wellington Rd., Clayton, Victoria, Australia
  2. 2Infectious Diseases
  3. 3Microbiology Departments, Austin Health, Heidelberg, Victoria, Australia
  • ↵* Corresponding author. Mailing address: Infectious Diseases Department, Austin Health, P.O. Box 5555, Heidelberg, Victoria 3084, Australia. Phone: 61 3 9496 6676. Fax: 61 3 9496 6677. E-mail: Benjamin.Howden{at}austin.org.au
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Genomic Analysis Reveals a Point Mutation in the Two-Component Sensor Gene graS That Leads to Intermediate Vancomycin Resistance in Clinical Staphylococcus aureus
Benjamin P. Howden, Timothy P. Stinear, David L. Allen, Paul D. R. Johnson, Peter B. Ward, John K. Davies
Antimicrobial Agents and Chemotherapy Sep 2008, 52 (10) 3755-3762; DOI: 10.1128/AAC.01613-07

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Genomic Analysis Reveals a Point Mutation in the Two-Component Sensor Gene graS That Leads to Intermediate Vancomycin Resistance in Clinical Staphylococcus aureus
Benjamin P. Howden, Timothy P. Stinear, David L. Allen, Paul D. R. Johnson, Peter B. Ward, John K. Davies
Antimicrobial Agents and Chemotherapy Sep 2008, 52 (10) 3755-3762; DOI: 10.1128/AAC.01613-07
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KEYWORDS

Genes, Bacterial
Point Mutation
Staphylococcus aureus
vancomycin resistance

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