Mechanisms of Resistance

Gain-of-Function Mutations in the Transcription Factor MRR1 Are Responsible for Overexpression of the MDR1 Efflux Pump in Fluconazole-Resistant Candida dubliniensis Strains

Sabrina Schubert, P. David Rogers, Joachim Morschhäuser
DOI: 10.1128/AAC.00740-08

Article Information

DOI 
https://doi.org/10.1128/AAC.00740-08
PubMed 
18809934
Published By 
American Society for Microbiology Journals
History 
  • Received June 5, 2008
  • Returned for modification August 20, 2008
  • Accepted September 14, 2008
  • Published online November 19, 2008.
Copyright & Usage 
Copyright © 2008 American Society for Microbiology

Article Versions

Author Information

  1. Sabrina Schubert1,
  2. P. David Rogers2 and
  3. Joachim Morschhäuser1*
  1. 1Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, Würzburg D-97070, Germany
  2. 2Department of Pharmacy and Pharmaceutical Sciences, College of Pharmacy, and Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Children's Foundation Research Center at Le Bonheur Children's Medical Center, Memphis, Tennessee
  • ↵* Corresponding author. Mailing address: Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, Würzburg D-97070, Germany. Phone: 49-931-31 21 52. Fax: 49-931-31 25 78. E-mail: joachim.morschhaeuser{at}mail.uni-wuerzburg.de

  • † Supplemental material for this article may be found at http://aac.asm.org/ .

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KEYWORDS

ATP Binding Cassette Transporter, Subfamily B, Member 1
Candida
Drug Resistance, Fungal
Gene Expression Regulation, Fungal
mutation
transcription factors

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