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Mechanisms of Resistance

MexCD-OprJ Multidrug Efflux System of Pseudomonas aeruginosa: Involvement in Chlorhexidine Resistance and Induction by Membrane-Damaging Agents Dependent upon the AlgU Stress Response Sigma Factor

Sebastien Fraud, Aaron J. Campigotto, Zhilin Chen, Keith Poole
Sebastien Fraud
Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6
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Aaron J. Campigotto
Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6
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Zhilin Chen
Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6
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Keith Poole
Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6
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  • For correspondence: poolek@queensu.ca
DOI: 10.1128/AAC.01072-08
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Article Information

DOI 
https://doi.org/10.1128/AAC.01072-08
PubMed 
18838593

Published By 
American Society for Microbiology Journals
History 
  • Received August 8, 2008
  • Returned for modification September 7, 2008
  • Accepted September 27, 2008
  • Published online November 19, 2008.

Copyright & Usage 
Copyright © 2008 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (October 06, 2008).
  • You are viewing the most recent version of this article.

Author Information

  1. Sebastien Fraud†,
  2. Aaron J. Campigotto†,
  3. Zhilin Chen and
  4. Keith Poole*
  1. Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6
  • ↵† Both authors contributed equally to this work.

  • ↵* Corresponding author. Mailing address: Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada K7L 3N6l. Phone: (613) 533-6677. Fax: (613) 533-6796. E-mail: poolek{at}queensu.ca
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MexCD-OprJ Multidrug Efflux System of Pseudomonas aeruginosa: Involvement in Chlorhexidine Resistance and Induction by Membrane-Damaging Agents Dependent upon the AlgU Stress Response Sigma Factor
Sebastien Fraud, Aaron J. Campigotto, Zhilin Chen, Keith Poole
Antimicrobial Agents and Chemotherapy Nov 2008, 52 (12) 4478-4482; DOI: 10.1128/AAC.01072-08

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MexCD-OprJ Multidrug Efflux System of Pseudomonas aeruginosa: Involvement in Chlorhexidine Resistance and Induction by Membrane-Damaging Agents Dependent upon the AlgU Stress Response Sigma Factor
Sebastien Fraud, Aaron J. Campigotto, Zhilin Chen, Keith Poole
Antimicrobial Agents and Chemotherapy Nov 2008, 52 (12) 4478-4482; DOI: 10.1128/AAC.01072-08
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  • Top
  • Article
    • ABSTRACT
    • CHX-induced mexCD-oprJ expression is AlgU dependent.
    • Additional membrane-active agents induce mexCD-oprJ.
    • MexCD-OprJ and CHX resistance.
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
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KEYWORDS

Anti-Infective Agents, Local
chlorhexidine
Drug Resistance, Bacterial
Gene Expression Regulation, Bacterial
Pseudomonas aeruginosa

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