Antimicrobial Activities of Tigecycline and Other Broad-Spectrum Antimicrobials Tested against Serine Carbapenemase- and Metallo-β-Lactamase-Producing Enterobacteriaceae: Report from the SENTRY Antimicrobial Surveillance Program

DOI: 10.1128/AAC.01114-07

Article Figures & Data

TABLE 1.

Distribution of carbapenemase-producing Enterobacteriaceae isolates according to carbapenemase type and medical center location

Organism (no. of strains)	Carbapenemase	Medical center		Tigecycline MIC range (μg/ml)
Organism (no. of strains)	Carbapenemase	No.	Location (no. of strains)	Tigecycline MIC range (μg/ml)
K. pneumoniae (53)	KPC-2/3	4	New York, NY (37)	0.25-4
	KPC-2	1	Mineola, NY (6)	1-2
	VIM-1	1	Athens, Greece (10)	0.12-1
K. oxytoca (7)	KPC-2	2	Little Rock, AK (3)	0.25-0.5
	KPC-2/3	1	New York, NY (3)	0.12-1
	KPC-3	1	Charlottesville, VA (1)	0.5
C. freundii (9)	KPC-2/3	2	New York, NY (7)	0.25-2
	KPC-2	1	Mineola, NY (1)	1
	KPC-3	1	Wilmington, DE (1)	0.12
E. cloacae (22)	KPC-2/3	2	New York, NY (3)	0.12-0.5
	KPC-2	1	Charlottesville, VA (3)	0.5
	NMC-A	1	New York, NY (1)	0.12
	IMP-1	1	Istanbul, Turkey (10)	0.25-0.5
		1	Ankara, Turkey (1)	1
		1	Madrid, Spain (2)	0.25-0.5
	VIM-1	1	Genoa, Italy (1)	0.25
		1	Catania, Italy (1)	0.25
E. gergoviae (1)	KPC-3	1	New York, NY (1)	0.25
E. hormaechei (1)	KPC-2	1	New York, NY (1)	2
S. marcescens(7)	KPC-2/3	2	New York, NY (2)	0.5-2
	SME-1	1	Mineola, NY (1)	0.5
		1	New York, NY (1)	0.5
		1	Seattle, WA (1)	1
		1	Houston, TX (2)	0.5-1
E. coli (4)	KPC-2/3	2	New York, NY (3)	0.12-1
		1	Cleveland, OH (1)	0.12

TABLE 2.

Antimicrobial activities of tigecycline and comparators against carbapenemase-producing Enterobacteriaceae

Organism (no. tested) and agent	MIC₅₀	MIC₉₀	% Susceptible^a	% Resistant^a
All Enterobacteriaceae (104)
Tigecycline	0.5	1	100.0	0.0
Tetracycline	4	>8	35.6	19.2
Imipenem	8	>8	37.5	37.5
Meropenem	8	>8	32.7	50.0
Ertapenem	8	32	7.7	73.1
Piperacillin-tazobactam	>64	>64	10.7	76.2
Cefepime	>16	>16	26.2	59.5
Aztreonam	>16	>16	15.5	78.6
Ciprofloxacin	4	>4	32.1	60.7
Gentamicin	4	>8	50.0	33.3
Amikacin	8	32	73.3	8.3
Polymyxin B	≤1	>4	88.1^b	11.9^b
Klebsiella spp. (60)
Tigecycline	1	2	100.0	0.0
Tetracycline	4	>8	66.7	13.3
Imipenem	8	16	21.7	46.7
Meropenem	>8	>8	20.0	61.7
Ertapenem	>8	>32	5.0	83.3
Piperacillin-tazobactam	>64	>64	0.0	95.8
Cefepime	>16	>16	18.8	64.6
Aztreonam	>16	>16	10.4	87.5
Ciprofloxacin	>4	>4	14.6	79.2
Gentamicin	≤2	>8	58.3	31.2
Amikacin	16	>32	53.3	13.3
Polymyxin B	≤1	≤1	93.3^b	6.7^b
Enterobacter spp. (24)
Tigecycline	0.25	0.5	100.0	0.0
Tetracycline	4	>8	70.8	20.8
Imipenem	4	>8	54.2	17.7
Meropenem	8	>8	33.3	41.7
Ertapenem	>8	>16	8.3	12.5
Piperacillin-tazobactam	32	>64	19.0	42.9
Cefepime	>16	>16	9.5	85.7
Aztreonam	>16	>16	28.6	57.1
Ciprofloxacin	0.5	>4	61.9	33.3
Gentamicin	8	>8	42.9	38.1
Amikacin	2	16	95.2	4.8
Polymyxin B	≤1	≤1	95.2^b	4.8^b