DOI: 10.1128/AAC.01519-08
Article Figures & Data
Tables
- TABLE 1.
MIC50s, MIC90s, and percent susceptibilities of urine CTX-M ESBL-producing isolates to the study antimicrobial agents
Drug Value for CTX-M ESBL-producing isolates (n = 46) MIC50 (μg/ml) MIC90 (μg/ml) % Susceptible Fosfomycin 0.5 64 91.3 Nitrofurantoin 16 64 73.9 Doxycycline 16 16 10.9 Ciprofloxacin 32 32 4.3 Cefdinir alone 16 16 0 Amoxicillin-clavulanate alone 32/4 32/4 10.9 Cefdinir plus amoxicillin-clavulanate 0.25a 2a 89.1 Ertapenem 0.06 0.25 100 ↵ a Cefdinir MIC in the presence of a fixed concentration of 8 μg/ml amoxicillin and 4 μg/ml clavulanate; percent-susceptible value is based upon the approved cefdinir-susceptible breakpoint of <1 μg/ml (5).
- TABLE 2.
MIC50s, MIC90s, and percent susceptibilities of urine SHV or TEM ESBL-producing isolates
Drug Value for SHV or TEM ESBL-producing isolates (n = 11) MIC50 (μg/ml) MIC90 (μg/ml) % Susceptible Fosfomycin 4 8 100 Nitrofurantoin 64 64 45.5 Doxycycline 16 16 18.2 Ciprofloxacin 32 32 36.4 Cefdinir alone 4 16 0 Amoxicillin-clavulanate alone 32/4 32/4 45.5 Cefdinir plus amoxicillin-clavulanate 0.06a 8a 81.8 Ertapenem 0.12 1 100 ↵ a Cefdinir MIC in the presence of a fixed concentration of 8 μg/ml amoxicillin and 4 μg/ml clavulanate; percent-susceptible value is based upon the approved cefdinir-susceptible breakpoint of <1 μg/ml (5).
