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Experimental Therapeutics

Antimicrobial Activity of Curcumin against Helicobacter pylori Isolates from India and during Infections in Mice

Ronita De, Parag Kundu, Snehasikta Swarnakar, T. Ramamurthy, Abhijit Chowdhury, G. Balakrish Nair, Asish K. Mukhopadhyay
Ronita De
1National Institute of Cholera and Enteric Diseases, Kolkata 700010, India
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Parag Kundu
2Indian Institute of Chemical Biology, Kolkata 700032, India
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Snehasikta Swarnakar
2Indian Institute of Chemical Biology, Kolkata 700032, India
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T. Ramamurthy
1National Institute of Cholera and Enteric Diseases, Kolkata 700010, India
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Abhijit Chowdhury
3School of Digestive Diseases, Institute of Post Graduate Medical Education and Research, Kolkata, India
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G. Balakrish Nair
1National Institute of Cholera and Enteric Diseases, Kolkata 700010, India
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Asish K. Mukhopadhyay
1National Institute of Cholera and Enteric Diseases, Kolkata 700010, India
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  • For correspondence: asish_mukhopadhyay@yahoo.com
DOI: 10.1128/AAC.01242-08
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ABSTRACT

Treatment failure is a major cause of concern for the Helicobacter pylori-related gastroduodenal diseases like gastritis, peptic ulcer, and gastric cancer. Curcumin, diferuloylmethane from turmeric, has recently been shown to arrest H. pylori growth. The antibacterial activity of curcumin against 65 clinical isolates of H. pylori in vitro and during protection against H. pylori infection in vivo was examined. The MIC of curcumin ranges from 5 μg/ml to 50 μg/ml, showing its effectiveness in inhibiting H. pylori growth in vitro irrespective of the genetic makeup of the strains. The nucleotide sequences of the aroE genes, encoding shikimate dehydrogenase, against which curcumin seems to act as a noncompetitive inhibitor, from H. pylori strains presenting differential curcumin MICs showed that curcumin-mediated growth inhibition of Indian H. pylori strains may not be always dependent on the shikimate pathway. The antimicrobial effect of curcumin in H. pylori-infected C57BL/6 mice and its efficacy in reducing the gastric damage due to infection were examined histologically. Curcumin showed immense therapeutic potential against H. pylori infection as it was highly effective in eradication of H. pylori from infected mice as well as in restoration of H. pylori-induced gastric damage. This study provides novel insights into the therapeutic effect of curcumin against H. pylori infection, suggesting its potential as an alternative therapy, and opens the way for further studies on identification of novel antimicrobial targets of curcumin.

  • Copyright © 2009 American Society for Microbiology
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Antimicrobial Activity of Curcumin against Helicobacter pylori Isolates from India and during Infections in Mice
Ronita De, Parag Kundu, Snehasikta Swarnakar, T. Ramamurthy, Abhijit Chowdhury, G. Balakrish Nair, Asish K. Mukhopadhyay
Antimicrobial Agents and Chemotherapy Mar 2009, 53 (4) 1592-1597; DOI: 10.1128/AAC.01242-08

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Antimicrobial Activity of Curcumin against Helicobacter pylori Isolates from India and during Infections in Mice
Ronita De, Parag Kundu, Snehasikta Swarnakar, T. Ramamurthy, Abhijit Chowdhury, G. Balakrish Nair, Asish K. Mukhopadhyay
Antimicrobial Agents and Chemotherapy Mar 2009, 53 (4) 1592-1597; DOI: 10.1128/AAC.01242-08
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KEYWORDS

Anti-Bacterial Agents
curcumin
Helicobacter Infections
Helicobacter pylori

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