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Mechanisms of Action: Physiological Effects

In Vivo and In Vitro Patterns of the Activity of Simocyclinone D8, an Angucyclinone Antibiotic from Streptomyces antibioticus

Lisa M. Oppegard, Bree L. Hamann, Kathryn R. Streck, Keith C. Ellis, Hans-Peter Fiedler, Arkady B. Khodursky, Hiroshi Hiasa
Lisa M. Oppegard
1Department of Pharmacology, University of Minnesota Medical School—Twin Cities, Minneapolis, Minnesota 55455
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Bree L. Hamann
2Department of Biochemistry, Molecular Biology, and Biophysics and Biotechnology Institute, University of Minnesota, St. Paul, Minnesota 55108
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Kathryn R. Streck
1Department of Pharmacology, University of Minnesota Medical School—Twin Cities, Minneapolis, Minnesota 55455
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Keith C. Ellis
3Department of Medicinal Chemistry and Institute for Therapeutic Discovery and Development, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55414
4Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298
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Hans-Peter Fiedler
5Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany
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Arkady B. Khodursky
2Department of Biochemistry, Molecular Biology, and Biophysics and Biotechnology Institute, University of Minnesota, St. Paul, Minnesota 55108
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Hiroshi Hiasa
1Department of Pharmacology, University of Minnesota Medical School—Twin Cities, Minneapolis, Minnesota 55455
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  • For correspondence: hiasa001@umn.edu
DOI: 10.1128/AAC.01440-08
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Article Information

DOI 
https://doi.org/10.1128/AAC.01440-08
PubMed 
19273673

Published By 
American Society for Microbiology Journals
History 
  • Received October 28, 2008
  • Returned for modification December 8, 2008
  • Accepted March 1, 2009
  • Published online April 24, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (March 09, 2009).
  • You are viewing the most recent version of this article.

Author Information

  1. Lisa M. Oppegard1,
  2. Bree L. Hamann2,
  3. Kathryn R. Streck1,
  4. Keith C. Ellis3,4,
  5. Hans-Peter Fiedler5,
  6. Arkady B. Khodursky2 and
  7. Hiroshi Hiasa1*
  1. 1Department of Pharmacology, University of Minnesota Medical School—Twin Cities, Minneapolis, Minnesota 55455
  2. 2Department of Biochemistry, Molecular Biology, and Biophysics and Biotechnology Institute, University of Minnesota, St. Paul, Minnesota 55108
  3. 3Department of Medicinal Chemistry and Institute for Therapeutic Discovery and Development, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55414
  4. 4Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia 23298
  5. 5Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany
  • ↵* Corresponding author. Mailing address: Department of Pharmacology, University of Minnesota Medical School—Twin Cities, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455. Phone: (612) 626-3101. Fax: (612) 625-8408. E-mail: hiasa001{at}umn.edu
  • † Supplemental material for this article may be found at http://aac.asm.org/ .

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In Vivo and In Vitro Patterns of the Activity of Simocyclinone D8, an Angucyclinone Antibiotic from Streptomyces antibioticus
Lisa M. Oppegard, Bree L. Hamann, Kathryn R. Streck, Keith C. Ellis, Hans-Peter Fiedler, Arkady B. Khodursky, Hiroshi Hiasa
Antimicrobial Agents and Chemotherapy Apr 2009, 53 (5) 2110-2119; DOI: 10.1128/AAC.01440-08

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In Vivo and In Vitro Patterns of the Activity of Simocyclinone D8, an Angucyclinone Antibiotic from Streptomyces antibioticus
Lisa M. Oppegard, Bree L. Hamann, Kathryn R. Streck, Keith C. Ellis, Hans-Peter Fiedler, Arkady B. Khodursky, Hiroshi Hiasa
Antimicrobial Agents and Chemotherapy Apr 2009, 53 (5) 2110-2119; DOI: 10.1128/AAC.01440-08
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KEYWORDS

Anti-Bacterial Agents
Escherichia coli
Staphylococcus aureus
Streptomyces antibioticus

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