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Mechanisms of Resistance

Role of the Mycobacterium tuberculosis P55 Efflux Pump in Intrinsic Drug Resistance, Oxidative Stress Responses, and Growth

Santiago Ramón-García, Carlos Martín, Charles J. Thompson, José A. Aínsa
Santiago Ramón-García
1Departamento de Microbiología, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Zaragoza 50009, and CIBER Enfermedades Respiratorias, Spain
2Department of Microbiology and Immunology, Life Sciences Centre, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada
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  • For correspondence: ramon@interchange.ubc.ca
Carlos Martín
1Departamento de Microbiología, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Zaragoza 50009, and CIBER Enfermedades Respiratorias, Spain
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Charles J. Thompson
2Department of Microbiology and Immunology, Life Sciences Centre, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada
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José A. Aínsa
1Departamento de Microbiología, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Zaragoza 50009, and CIBER Enfermedades Respiratorias, Spain
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DOI: 10.1128/AAC.00550-09
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Article Information

DOI 
https://doi.org/10.1128/AAC.00550-09
PubMed 
19564371

Published By 
American Society for Microbiology Journals
History 
  • Received April 23, 2009
  • Returned for modification June 10, 2009
  • Accepted June 18, 2009
  • Published online August 14, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (June 29, 2009).
  • You are viewing the most recent version of this article.

Author Information

  1. Santiago Ramón-García1,2*,
  2. Carlos Martín1,
  3. Charles J. Thompson2† and
  4. José A. Aínsa1†
  1. 1Departamento de Microbiología, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Zaragoza 50009, and CIBER Enfermedades Respiratorias, Spain
  2. 2Department of Microbiology and Immunology, Life Sciences Centre, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada
  • ↵* Corresponding author. Mailing address: Department of Microbiology and Immunology, Life Science Centre, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada. Phone: (604) 822-8094. Fax: (604) 822-6041. E-mail: ramon{at}interchange.ubc.ca
  • ↵† These authors contributed equally to this work.

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Role of the Mycobacterium tuberculosis P55 Efflux Pump in Intrinsic Drug Resistance, Oxidative Stress Responses, and Growth
Santiago Ramón-García, Carlos Martín, Charles J. Thompson, José A. Aínsa
Antimicrobial Agents and Chemotherapy Aug 2009, 53 (9) 3675-3682; DOI: 10.1128/AAC.00550-09

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Role of the Mycobacterium tuberculosis P55 Efflux Pump in Intrinsic Drug Resistance, Oxidative Stress Responses, and Growth
Santiago Ramón-García, Carlos Martín, Charles J. Thompson, José A. Aínsa
Antimicrobial Agents and Chemotherapy Aug 2009, 53 (9) 3675-3682; DOI: 10.1128/AAC.00550-09
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KEYWORDS

antitubercular agents
Bacterial Proteins
Drug Resistance, Multiple, Bacterial
Membrane Transport Proteins
Mycobacterium tuberculosis
oxidative stress

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