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Mechanisms of Resistance

Contribution of dfrA and inhA Mutations to the Detection of Isoniazid-Resistant Mycobacterium tuberculosis Isolates

Yu Min Ho, Yong-Jiang Sun, Sin-Yew Wong, Ann S. G. Lee
Yu Min Ho
1Division of Medical Sciences, National Cancer Centre, Singapore 169610
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Yong-Jiang Sun
2Department of Infectious Disease, Tan Tock Seng Hospital, Singapore 308433
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Sin-Yew Wong
2Department of Infectious Disease, Tan Tock Seng Hospital, Singapore 308433
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Ann S. G. Lee
1Division of Medical Sciences, National Cancer Centre, Singapore 169610
3Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
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  • For correspondence: dmslsg@nccs.com.sg
DOI: 10.1128/AAC.00433-09
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Article Information

DOI 
https://doi.org/10.1128/AAC.00433-09
PubMed 
19581462

Published By 
American Society for Microbiology Journals
History 
  • Received March 31, 2009
  • Returned for modification April 28, 2009
  • Accepted June 25, 2009
  • Published online August 14, 2009.

Copyright & Usage 
Copyright © 2009 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (July 06, 2009).
  • You are viewing the most recent version of this article.

Author Information

  1. Yu Min Ho1,
  2. Yong-Jiang Sun2,
  3. Sin-Yew Wong2 and
  4. Ann S. G. Lee1,3*
  1. 1Division of Medical Sciences, National Cancer Centre, Singapore 169610
  2. 2Department of Infectious Disease, Tan Tock Seng Hospital, Singapore 308433
  3. 3Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
  • ↵* Corresponding author. Mailing address: Division of Medical Sciences, National Cancer Centre, Singapore, 11 Hospital Drive, Singapore 169610, Republic of Singapore. Phone: 65 6436-8313. Fax: 65 6372-0161. E-mail: dmslsg{at}nccs.com.sg

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Contribution of dfrA and inhA Mutations to the Detection of Isoniazid-Resistant Mycobacterium tuberculosis Isolates
Yu Min Ho, Yong-Jiang Sun, Sin-Yew Wong, Ann S. G. Lee
Antimicrobial Agents and Chemotherapy Aug 2009, 53 (9) 4010-4012; DOI: 10.1128/AAC.00433-09

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Contribution of dfrA and inhA Mutations to the Detection of Isoniazid-Resistant Mycobacterium tuberculosis Isolates
Yu Min Ho, Yong-Jiang Sun, Sin-Yew Wong, Ann S. G. Lee
Antimicrobial Agents and Chemotherapy Aug 2009, 53 (9) 4010-4012; DOI: 10.1128/AAC.00433-09
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KEYWORDS

antitubercular agents
Bacterial Proteins
Drug Resistance, Bacterial
isoniazid
Mycobacterium tuberculosis
Oxidoreductases

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