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Mechanisms of Resistance

CraA, a Major Facilitator Superfamily Efflux Pump Associated with Chloramphenicol Resistance in Acinetobacter baumannii

I. Roca, S. Marti, P. Espinal, P. Martínez, I. Gibert, J. Vila
I. Roca
1Department of Microbiology, Hospital Clínic, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain
2Institut de Biotecnologia i de Biomedicina i Departament de Genètica i de Microbiologia, Grup de Genètica Molecular Bacteriana, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
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S. Marti
1Department of Microbiology, Hospital Clínic, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain
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P. Espinal
1Department of Microbiology, Hospital Clínic, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain
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P. Martínez
2Institut de Biotecnologia i de Biomedicina i Departament de Genètica i de Microbiologia, Grup de Genètica Molecular Bacteriana, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
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I. Gibert
2Institut de Biotecnologia i de Biomedicina i Departament de Genètica i de Microbiologia, Grup de Genètica Molecular Bacteriana, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
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J. Vila
1Department of Microbiology, Hospital Clínic, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain
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  • For correspondence: jvila@ub.edu
DOI: 10.1128/AAC.00584-09
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Tables

  • TABLE 1.

    MICs of antimicrobial agents in the investigated A. baumannii strains

    Antimicrobial agentMIC (μg/ml) for indicated strain
    ATCC 19606JVAB01 (Orf3 mutant)JVAB01 + pJV103 (Orf3+)
    Tetracycline6696
    Nalidixic acid121212
    Ciprofloxacin0.250.250.25
    Norfloxacin666
    Imipenem0.750.750.75
    Clindamycin>256>256>256
    Erythromycin1.51.51.5
    Chloramphenicol>2562192
    Chloramphenicol + PAβN321.516
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CraA, a Major Facilitator Superfamily Efflux Pump Associated with Chloramphenicol Resistance in Acinetobacter baumannii
I. Roca, S. Marti, P. Espinal, P. Martínez, I. Gibert, J. Vila
Antimicrobial Agents and Chemotherapy Aug 2009, 53 (9) 4013-4014; DOI: 10.1128/AAC.00584-09

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CraA, a Major Facilitator Superfamily Efflux Pump Associated with Chloramphenicol Resistance in Acinetobacter baumannii
I. Roca, S. Marti, P. Espinal, P. Martínez, I. Gibert, J. Vila
Antimicrobial Agents and Chemotherapy Aug 2009, 53 (9) 4013-4014; DOI: 10.1128/AAC.00584-09
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KEYWORDS

Acinetobacter baumannii
Anti-Bacterial Agents
Bacterial Proteins
Chloramphenicol Resistance
Drug Resistance, Multiple, Bacterial

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