Antimicrobial Agents and Chemotherapy: 54 (11)

November 2010; Volume 54,Issue 11

Mechanisms of Resistance

Mechanisms of Resistance
Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans
Claire M. Martel, Josie E. Parker, Oliver Bader, Michael Weig, Uwe Gross, Andrew G. S. Warrilow, Nicola Rolley, Diane E. Kelly, Steven L. Kelly
Mechanisms of Resistance
Phenotypic and Biochemical Comparison of the Carbapenem-Hydrolyzing Activities of Five Plasmid-Borne AmpC β-Lactamases
Hedi Mammeri, Hélène Guillon, François Eb, Patrice Nordmann
Mechanisms of Resistance
Emergence and Distribution of Plasmids Bearing the bla_OXA-51-Like Gene with an Upstream ISAba1 in Carbapenem-Resistant Acinetobacter baumannii Isolates in Taiwan
Te-Li Chen, Yi-Tzu Lee, Shu-Chen Kuo, Po-Ren Hsueh, Feng-Yee Chang, Leung-Kei Siu, Wen-Chien Ko, Chang-Phone Fung
Mechanisms of Resistance
Diversity of Staphylococcal Cassette Chromosome mec Elements in Predominant Methicillin-Resistant Staphylococcus aureus Clones in a Small Geographic Area
Patrick Basset, Laurence Senn, Valérie Vogel, Giorgio Zanetti, Dominique S. Blanc
Mechanisms of Resistance
The Development of Ciprofloxacin Resistance in Pseudomonas aeruginosa Involves Multiple Response Stages and Multiple Proteins
Hsun-Cheng Su, Kevin Ramkissoon, Janet Doolittle, Martha Clark, Jainab Khatun, Ashley Secrest, Matthew C. Wolfgang, Morgan C. Giddings
Mechanisms of Resistance
vanM, a New Glycopeptide Resistance Gene Cluster Found in Enterococcus faecium
Xiaogang Xu, Dongfang Lin, Guoquan Yan, Xinyu Ye, Shi Wu, Yan Guo, Demei Zhu, Fupin Hu, Yingyuan Zhang, Fu Wang, George A. Jacoby, Minggui Wang
Mechanisms of Resistance
TelA Contributes to the Innate Resistance of Listeria monocytogenes to Nisin and Other Cell Wall-Acting Antibiotics
Barry Collins, Susan Joyce, Colin Hill, Paul D. Cotter, R. Paul Ross
Mechanisms of Resistance
Mutations in 23S rRNA at the Peptidyl Transferase Center and Their Relationship to Linezolid Binding and Cross-Resistance
Katherine S. Long, Christian Munck, Theis M. B. Andersen, Maria A. Schaub, Sven N. Hobbie, Erik C. Böttger, Birte Vester
Mechanisms of Resistance
Mutational Analysis of Flucytosine Resistance in Candida glabrata
Thomas D. Edlind, Santosh K. Katiyar
Mechanisms of Resistance
Characterization of Two Newly Identified Genes, vgaD and vatG, Conferring Resistance to Streptogramin A in Enterococcus faecium
Young-Hee Jung, Eun Shim Shin, Okgene Kim, Jung Sik Yoo, Kyeong Min Lee, Jae Il Yoo, Gyung Tae Chung, Yeong Seon Lee
Mechanisms of Resistance
ampG Gene of Pseudomonas aeruginosa and Its Role in β-Lactamase Expression
Ying Zhang, Qiyu Bao, Luc A. Gagnon, Ann Huletsky, Antonio Oliver, Shouguang Jin, Taimour Langaee
Mechanisms of Resistance
Emergence and Molecular Characterization of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates from the Delhi Region in India
Alka Khanna, V. Samuel Raj, Bansidhar Tarai, Ruchi Sood, Pawan Kumar Pareek, Dilip J. Upadhyay, Pawan Sharma, Ashok Rattan, Kulvinder Singh Saini, Harpal Singh
Mechanisms of Resistance
Thr202Ala in thyA Is a Marker for the Latin American Mediterranean Lineage of the Mycobacterium tuberculosis Complex Rather than Para-Aminosalicylic Acid Resistance
Silke Feuerriegel, Claudio Köser, Leona Trübe, John Archer, Sabine Rüsch Gerdes, Elvira Richter, Stefan Niemann
Mechanisms of Resistance
Comparative Biochemical and Computational Study of the Role of Naturally Occurring Mutations at Ambler Positions 104 and 170 in GES β-Lactamases
Stathis D. Kotsakis, Vivi Miriagou, Eva Tzelepi, Leonidas S. Tzouvelekis
Mechanisms of Resistance
GES Extended-Spectrum β-Lactamases in Acinetobacter baumannii Isolates in Belgium
Pierre Bogaerts, Thierry Naas, Farid El Garch, Gaelle Cuzon, Ariane Deplano, Tugba Delaire, Te-Din Huang, Benedicte Lissoir, Patrice Nordmann, Youri Glupczynski
Mechanisms of Resistance
A mecA-Negative Strain of Methicillin-Resistant Staphylococcusaureus with High-Level β-Lactam Resistance Contains Mutations in Three Genes
Ritu Banerjee, Michael Gretes, Christopher Harlem, Li Basuino, Henry F. Chambers
Mechanisms of Resistance
Antimicrobial Resistance Testing of Verocytotoxin-Producing Escherichia coli and First Description of TEM-52 Extended-Spectrum β-Lactamase in Serogroup O26
Glenn Buvens, Pierre Bogaerts, Youri Glupczynski, Sabine Lauwers, Denis Piérard
Mechanisms of Resistance
Emergence of Metallo-β-Lactamase NDM-1-Producing Multidrug-Resistant Escherichia coli in Australia
Laurent Poirel, Emilie Lagrutta, Peter Taylor, Jeanette Pham, Patrice Nordmann
Mechanisms of Resistance
Reduced Expression of the vca0421 Gene of Vibrio cholerae O1 Results in Innate Resistance to Ciprofloxacin
Jun Okuda, Naoki Hayashi, Yuka Wakahara, Naomasa Gotoh
Mechanisms of Resistance
Demonstration of Conjugative Transposon (Tn5397)-Mediated Horizontal Gene Transfer between Clostridium difficile and Enterococcus faecalis
Azmiza S. Jasni, Peter Mullany, Haitham Hussain, Adam P. Roberts
Mechanisms of Resistance
Genetic and Functional Variability of AmpC-Type β-Lactamases from Acinetobacter baumannii
José-Manuel Rodríguez-Martínez, Laurent Poirel, Patrice Nordmann
Mechanisms of Resistance
Overexpression of the adeB Gene in Clinical Isolates of Tigecycline-Nonsusceptible Acinetobacter baumannii without Insertion Mutations in adeRS
Jun-Ren Sun, Ming-Chin Chan, Tein-Yao Chang, Wei-Yao Wang, Tzong-Shi Chiueh
Mechanisms of Resistance
bla _ROB-1 Presence on pB1000 in Haemophilus influenzae Is Widespread, and Variable Cefaclor Resistance Is Associated with Altered Penicillin-Binding Proteins
Stephen G. Tristram, Rachael Littlejohn, Richard S. Bradbury

Pharmacology

Pharmacology
Pharmacokinetics-Pharmacodynamics of a Respiratory Syncytial Virus Fusion Inhibitor in the Cotton Rat Model
Marie-Claude Rouan, Tom Gevers, Dirk Roymans, Loeckie de Zwart, David Nauwelaers, Marc De Meulder, Pieter van Remoortere, Marc Vanstockem, Anil Koul, Kenny Simmen, Koen Andries
Pharmacology
Therapeutic Drug Monitoring of Linezolid: a Retrospective Monocentric Analysis
Federico Pea, Mario Furlanut, Piergiorgio Cojutti, Francesco Cristini, Eleonora Zamparini, Loretta Franceschi, Pierluigi Viale
Pharmacology
Mathematical Modeling To Characterize the Inoculum Effect
Pratik Bhagunde, Kai-Tai Chang, Renu Singh, Vandana Singh, Kevin W. Garey, Michael Nikolaou, Vincent H. Tam
Pharmacology
Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine during Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania
Sofia Friberg Hietala, Andreas Mårtensson, Billy Ngasala, Sabina Dahlström, Niklas Lindegårdh, Anna Annerberg, Zul Premji, Anna Färnert, Pedro Gil, Anders Björkman, Michael Ashton
Pharmacology
Tolerance of Benznidazole in Treatment of Chagas' Disease in Adults
María-Jesús Pinazo, José Muñoz, Elizabeth Posada, Paulo López-Chejade, Montserrat Gállego, Edgar Ayala, Elena del Cacho, Dolors Soy, Joaquim Gascon

Experimental Therapeutics

Experimental Therapeutics
Bactericidal Potencies of New Regimens Are Not Predictive of Their Sterilizing Potencies in a Murine Model of Tuberculosis
Koen Andries, Tom Gevers, Nacer Lounis
Experimental Therapeutics
In Vitro and In Vivo Antifungal Susceptibilities of the Mucoralean Fungus Cunninghamella
F. Javier Pastor, Mery Ruíz-Cendoya, Isabel Pujol, Emilio Mayayo, Deanna A. Sutton, Josep Guarro
Experimental Therapeutics
Efficacy of Calcium-EDTA as an Inhibitor for Metallo-β-Lactamase in a Mouse Model of Pseudomonas aeruginosa Pneumonia
Nobumasa Aoki, Yoshikazu Ishii, Kazuhiro Tateda, Tomoo Saga, Soichiro Kimura, Yoshiaki Kikuchi, Tetsuo Kobayashi, Yoshinari Tanabe, Hiroki Tsukada, Fumitake Gejyo, Keizo Yamaguchi
Experimental Therapeutics
In Vivo and In Vitro Sensitivity of Fasciola hepatica to Triclabendazole Combined with Artesunate, Artemether, or OZ78
Urs Duthaler, Thomas A. Smith, Jennifer Keiser
Experimental Therapeutics
Reductions in Skin and Systemic Parasite Burdens as a Combined Effect of Topical Paromomycin and Oral Miltefosine Treatment of Mice Experimentally Infected with Leishmania (Leishmania) amazonensis
Marta Gontijo Aguiar, Aline Márcia Machado Pereira, Ana Paula Fernandes, Lucas Antonio Miranda Ferreira
Experimental Therapeutics
A Chimeric Protein That Functions as both an Anthrax Dual-Target Antitoxin and a Trivalent Vaccine
Gaobing Wu, Yuzhi Hong, Aizhen Guo, Chunfang Feng, Sha Cao, Cheng-Cai Zhang, Ruiping Shi, Yadi Tan, Ziduo Liu
Experimental Therapeutics
Impact of cyp51A Mutations on the Pharmacokinetic and Pharmacodynamic Properties of Voriconazole in a Murine Model of Disseminated Aspergillosis
Eleftheria Mavridou, Roger J. M. Bruggemann, Willem J. G. Melchers, Paul E. Verweij, Johan W. Mouton
Experimental Therapeutics
Should Moxifloxacin Be Used for the Treatment of Extensively Drug-Resistant Tuberculosis? An Answer from a Murine Model
Julien Poissy, Alexandra Aubry, Christine Fernandez, Marie-Catherine Lott, Aurelie Chauffour, Vincent Jarlier, Robert Farinotti, Nicolas Veziris
Experimental Therapeutics
Activity of the Histone Deacetylase Inhibitor FR235222 on Toxoplasma gondii: Inhibition of Stage Conversion of the Parasite Cyst Form and Study of New Derivative Compounds
Danièle Maubon, Alexandre Bougdour, Yung-Sing Wong, Marie-Pierre Brenier-Pinchart, Aurélie Curt, Mohamed-Ali Hakimi, Hervé Pelloux
Experimental Therapeutics
The Initial 96 Hours of Invasive Pulmonary Aspergillosis: Histopathology, Comparative Kinetics of Galactomannan and (1→3)-β-d-Glucan, and Consequences of Delayed Antifungal Therapy
William W. Hope, Vidmantas Petraitis, Ruta Petraitiene, Tamarra Aghamolla, John Bacher, Thomas J. Walsh
Experimental Therapeutics
In Vitro Profiling of Pramiconazole and In Vivo Evaluation in Microsporum canis Dermatitis and Candida albicans Vaginitis Laboratory Models
Kelly de Wit, Caroline Paulussen, An Matheeussen, Koen van Rossem, Paul Cos, Louis Maes

Susceptibility

Susceptibility
Environmental Study of Azole-Resistant Aspergillus fumigatus and Other Aspergilli in Austria, Denmark, and Spain
Klaus Leth Mortensen, Emilia Mellado, Cornelia Lass-Flörl, Juan Luis Rodriguez-Tudela, Helle Krogh Johansen, Maiken Cavling Arendrup
Susceptibility
Synergy Testing by Etest, Microdilution Checkerboard, and Time-Kill Methods for Pan-Drug-Resistant Acinetobacter baumannii
Madhuri M. Sopirala, Julie E. Mangino, Wondwossen A. Gebreyes, Beth Biller, Tammy Bannerman, Joan-Miquel Balada-Llasat, Preeti Pancholi
Susceptibility
Prevalence of Antimicrobial-Resistant Pathogens in Canadian Hospitals: Results of the Canadian Ward Surveillance Study (CANWARD 2008)
George G. Zhanel, Melanie DeCorby, Heather Adam, Michael R. Mulvey, Melissa McCracken, Philippe Lagacé-Wiens, Kimberly A. Nichol, Aleksandra Wierzbowski, Patricia J. Baudry, Franil Tailor, James A. Karlowsky, Andrew Walkty, Frank Schweizer, Jack Johnson, Daryl J. Hoban
and the Canadian Antimicrobial Resistance Alliance
Susceptibility
A Novel Galacto-Glycerolipid from Oxalis corniculata Kills Entamoeba histolytica and Giardia lamblia
Dipak Manna, Pradeep K. Dutta, Basudeb Achari, Anuradha Lohia
Susceptibility
Characteristics and Dissemination of Mosaic Penicillin-Binding Protein 2-Harboring Multidrug-Resistant Neisseria gonorrhoeae Isolates with Reduced Cephalosporin Susceptibility in Northern Taiwan
Chung-Ter Huang, Muh-Yong Yen, Wing-Wai Wong, Lan-Hui Li, Kun-Yen Lin, Mei-Hui Liao, Shu-Ying Li
Susceptibility
Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14α-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B
Claire M. Martel, Josie E. Parker, Andrew G. S. Warrilow, Nicola J. Rolley, Steven L. Kelly, Diane E. Kelly

Antiviral Agents

Antiviral Agents
Sulfated Derivatives of Escherichia coli K5 Capsular Polysaccharide Are Potent Inhibitors of Human Cytomegalovirus
Beatrice Mercorelli, Pasqua Oreste, Elisa Sinigalia, Giulia Muratore, David Lembo, Giorgio Palù, Arianna Loregian
Antiviral Agents
Efficacy and Safety of Intravenous Peramivir for Treatment of Seasonal Influenza Virus Infection
Shigeru Kohno, Hiroshi Kida, Masashi Mizuguchi, Jingoro Shimada
and for the S-021812 Clinical Study Group
Antiviral Agents
Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease
Peter W. White, Montse Llinàs-Brunet, Ma'an Amad, Richard C. Bethell, Gordon Bolger, Michael G. Cordingley, Jianmin Duan, Michel Garneau, Lisette Lagacé, Diane Thibeault, George Kukolj
Antiviral Agents
Pharmacokinetics and Pharmacogenomics of Once-Daily Raltegravir and Atazanavir in Healthy Volunteers
Michael Neely, Laurent Decosterd, Aurélie Fayet, Janice Soo Fern Lee, Ashley Margol, Meera Kanani, Julia di Iulio, Tido von Schoen-Angerer, Roger Jelliffe, Alexandra Calmy
Antiviral Agents
1-O-Hexadecyloxypropyl Cidofovir (CMX001) Effectively Inhibits Polyomavirus BK Replication in Primary Human Renal Tubular Epithelial Cells
Christine Hanssen Rinaldo, Rainer Gosert, Eva Bernhoff, Solrun Finstad, Hans H. Hirsch
Antiviral Agents
Hexadecyloxypropyl-Cidofovir (CMX001) Suppresses JC Virus Replication in Human Fetal Brain SVG Cell Cultures
Zhi-Gang Jiang, Jeffrey Cohen, Leslie J. Marshall, Eugene O. Major
Antiviral Agents
Mechanisms Involved in the Selection of HIV-1 Reverse Transcriptase Thumb Subdomain Polymorphisms Associated with Nucleoside Analogue Therapy Failure
Gilberto Betancor, Maria C. Puertas, María Nevot, César Garriga, Miguel A. Martínez, Javier Martinez-Picado, Luis Menéndez-Arias
Antiviral Agents
Distinct Mutation Pathways of Non-Subtype B HIV-1 during In Vitro Resistance Selection with Nonnucleoside Reverse Transcriptase Inhibitors
Ming-Tain Lai, Meiqing Lu, Peter J. Felock, Renee C. Hrin, Ying-Jie Wang, Youwei Yan, Sanjeev Munshi, Georgia B. McGaughey, Robert M. Tynebor, Thomas J. Tucker, Theresa M. Williams, Jay A. Grobler, Daria J. Hazuda, Philip M. McKenna, Michael D. Miller
Antiviral Agents
Genotypic Characterization of UL23 Thymidine Kinase and UL30 DNA Polymerase of Clinical Isolates of Herpes Simplex Virus: Natural Polymorphism and Mutations Associated with Resistance to Antivirals
Sonia Burrel, Claire Deback, Henri Agut, David Boutolleau
Antiviral Agents
In Vitro Mitochondrial Toxicity of Metacavir, a New Nucleoside Reverse Transcriptase Inhibitor for Treatment of Hepatitis B Virus
Pinghu Zhang, Luyong Zhang, Zhenzhou Jiang, Tao Wang, Hongkui Chen, Yating Xiong, Zhan Li
Antiviral Agents
Prevalence, Mutation Patterns, and Effects on Protease Inhibitor Susceptibility of the L76V Mutation in HIV-1 Protease
Thomas P. Young, Neil T. Parkin, Eric Stawiski, Tami Pilot-Matias, Roger Trinh, Dale J. Kempf, Michael Norton
Antiviral Agents
Low Frequency of Intermittent HIV-1 Semen Excretion in Patients Treated with Darunavir-Ritonavir at 600/100 Milligrams Twice a Day plus Two Nucleoside Reverse Transcriptase Inhibitors or Monotherapy
Sidonie Lambert-Niclot, Gilles Peytavin, Claudine Duvivier, Catherine Poirot, Michèle Algarte-Genin, Sophie Pakianather, Jean-Luc Meynard, Marc-Antoine Valantin, Jean-Michel Molina, Philippe Flandre, Christine Katlama, Vincent Calvez, Anne-Geneviève Marcelin

Chemistry; Biosynthesis

Chemistry; Biosynthesis
Synthesis and Spectrum of the Neoglycoside ACHN-490
James B. Aggen, Eliana S. Armstrong, Adam A. Goldblum, Paola Dozzo, Martin S. Linsell, Micah J. Gliedt, Darin J. Hildebrandt, Lee Ann Feeney, Aya Kubo, Rowena D. Matias, Sara Lopez, Marcela Gomez, Kenneth B. Wlasichuk, Raymond Diokno, George H. Miller, Heinz E. Moser

Mechanisms of Action

Mechanisms of Action: Physiological Effects
Discovery and Analysis of 4H-Pyridopyrimidines, a Class of Selective Bacterial Protein Synthesis Inhibitors
Wendy Ribble, Walter E. Hill, Urs A. Ochsner, Thale C. Jarvis, Joseph W. Guiles, Nebojsa Janjic, James M. Bullard
Mechanisms of Action: Physiological Effects
Sodium Nitrite-Mediated Killing of the Major Cystic Fibrosis Pathogens Pseudomonas aeruginosa, Staphylococcus aureus, and Burkholderia cepacia under Anaerobic Planktonic and Biofilm Conditions
Tiffany A. Major, Warunya Panmanee, Joel E. Mortensen, Larry D. Gray, Niel Hoglen, Daniel J. Hassett
Mechanisms of Action: Physiological Effects
Role of Arginine Deiminase of Streptococcus cristatus in Porphyromonas gingivalis Colonization
Jie Wu, Hua Xie
Mechanisms of Action: Physiological Effects
Subinhibitory Concentrations of Protein Synthesis-Inhibiting Antibiotics Promote Increased Expression of the agr Virulence Regulator and Production of Phenol-Soluble Modulin Cytolysins in Community-Associated Methicillin-Resistant Staphylococcus aureus
Hwang-Soo Joo, June L. Chan, Gordon Y. C. Cheung, Michael Otto

Clinical Therapeutics

Clinical Therapeutics
In Vitro and In Vivo Efficacy of Florfenicol for Treatment of Francisella asiatica Infection in Tilapia
Esteban Soto, Richard G. Endris, John P. Hawke
Clinical Therapeutics
Systematic Review and Meta-Analysis of the Efficacy of Appropriate Empiric Antibiotic Therapy for Sepsis
Mical Paul, Vered Shani, Eli Muchtar, Galia Kariv, Eyal Robenshtok, Leonard Leibovici
Clinical Therapeutics
Amikacin Monotherapy for Sepsis Caused by Panresistant Pseudomonas aeruginosa
Brice Layeux, Fabio Silvio Taccone, David Fagnoul, Jean-Louis Vincent, Frédérique Jacobs

Letters

LETTERS TO THE EDITOR
Frequency of Spontaneous Resistance to Fosfomycin Combined with Different Antibiotics in Pseudomonas aeruginosa
Alexandro Rodríguez-Rojas, Alejandro Couce, Jesús Blázquez*
LETTERS TO THE EDITOR
Importance of Infusion Volume and Pump Characteristics in Extended Administration of β-Lactam Antibiotics
Barbara Claus, Franky Buyle, Hugo Robays, Dirk Vogelaers
LETTERS TO THE EDITOR
Role of the Dihydrofolate Reductase DfrA (Rv2763c) in Trimethoprim-Sulfamethoxazole (Co-Trimoxazole) Resistance in Mycobacterium tuberculosis
Claudio U. Köser, David K. Summers, John A. C. Archer

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Table of Contents

Mechanisms of Resistance

Pharmacology

Experimental Therapeutics

Susceptibility

Antiviral Agents

Chemistry; Biosynthesis

Mechanisms of Action

Clinical Therapeutics

Letters

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