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Pharmacology

Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine during Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania

Sofia Friberg Hietala, Andreas Mårtensson, Billy Ngasala, Sabina Dahlström, Niklas Lindegårdh, Anna Annerberg, Zul Premji, Anna Färnert, Pedro Gil, Anders Björkman, Michael Ashton
Sofia Friberg Hietala
1Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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  • For correspondence: sofiafriberghietala@gmail.com
Andreas Mårtensson
2Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital/Karolinska Institutet, Solna, Sweden
3Division of Global Health, Department of Public Health Sciences, Karolinska Institutet, Solna, Sweden
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Billy Ngasala
4Department of Parasitology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
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Sabina Dahlström
2Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital/Karolinska Institutet, Solna, Sweden
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Niklas Lindegårdh
5Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
6Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom
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Anna Annerberg
5Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
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Zul Premji
4Department of Parasitology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
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Anna Färnert
2Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital/Karolinska Institutet, Solna, Sweden
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Pedro Gil
2Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital/Karolinska Institutet, Solna, Sweden
7Centre of Molecular and Structural Biomedicine, Institute of Biotechnology and Bioengineering, University of Algarve, Faro, Portugal
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Anders Björkman
2Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital/Karolinska Institutet, Solna, Sweden
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Michael Ashton
1Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
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DOI: 10.1128/AAC.00252-10
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Article Information

DOI 
https://doi.org/10.1128/AAC.00252-10
PubMed 
20713675

Published By 
American Society for Microbiology Journals
History 
  • Received February 20, 2010
  • Returned for modification April 6, 2010
  • Accepted August 7, 2010
  • Published online October 14, 2010.

Copyright & Usage 
Copyright © 2010 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (August 16, 2010).
  • You are viewing the most recent version of this article.

Author Information

  1. Sofia Friberg Hietala1*,
  2. Andreas Mårtensson2,3,
  3. Billy Ngasala4,
  4. Sabina Dahlström2,
  5. Niklas Lindegårdh5,6,
  6. Anna Annerberg5,
  7. Zul Premji4,
  8. Anna Färnert2,
  9. Pedro Gil2,7,
  10. Anders Björkman2 and
  11. Michael Ashton1
  1. 1Unit for Pharmacokinetics and Drug Metabolism, Department of Pharmacology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
  2. 2Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital/Karolinska Institutet, Solna, Sweden
  3. 3Division of Global Health, Department of Public Health Sciences, Karolinska Institutet, Solna, Sweden
  4. 4Department of Parasitology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
  5. 5Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
  6. 6Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom
  7. 7Centre of Molecular and Structural Biomedicine, Institute of Biotechnology and Bioengineering, University of Algarve, Faro, Portugal
  • ↵* Corresponding author. Mailing address: Department of Pharmacology, University of Gothenburg, Box 431, SE-405 30 Gothenburg, Sweden. Phone: 46 31 786 34 12. Fax: 46 31 786 32 84. E-mail: sofiafriberghietala{at}gmail.com

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Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine during Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania
Sofia Friberg Hietala, Andreas Mårtensson, Billy Ngasala, Sabina Dahlström, Niklas Lindegårdh, Anna Annerberg, Zul Premji, Anna Färnert, Pedro Gil, Anders Björkman, Michael Ashton
Antimicrobial Agents and Chemotherapy Oct 2010, 54 (11) 4780-4788; DOI: 10.1128/AAC.00252-10

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Population Pharmacokinetics and Pharmacodynamics of Artemether and Lumefantrine during Combination Treatment in Children with Uncomplicated Falciparum Malaria in Tanzania
Sofia Friberg Hietala, Andreas Mårtensson, Billy Ngasala, Sabina Dahlström, Niklas Lindegårdh, Anna Annerberg, Zul Premji, Anna Färnert, Pedro Gil, Anders Björkman, Michael Ashton
Antimicrobial Agents and Chemotherapy Oct 2010, 54 (11) 4780-4788; DOI: 10.1128/AAC.00252-10
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KEYWORDS

antimalarials
artemisinins
Ethanolamines
Fluorenes
Malaria, Falciparum

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