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Table of Contents

March 2010; Volume 54,Issue 3

Minireviews

  • Minireview
    Updated Functional Classification of β-Lactamases
    Karen Bush, George A. Jacoby

Antiviral Agents

  • Antiviral Agents
    Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines
    Megan H. Powdrill, Jerome Deval, Frank Narjes, Raffaele De Francesco, Matthias Götte
  • Antiviral Agents
    Stage-Dependent Inhibition of HIV-1 Replication by Antiretroviral Drugs in Cell Culture
    Daniel A. Donahue, Richard D. Sloan, Björn D. Kuhl, Tamara Bar-Magen, Susan M. Schader, Mark A. Wainberg
  • Free
    Antiviral Agents
    Detection of Molecular Markers of Drug Resistance in 2009 Pandemic Influenza A (H1N1) Viruses by Pyrosequencing
    Varough M. Deyde, Tiffany G. Sheu, A. Angelica Trujillo, Margaret Okomo-Adhiambo, Rebecca Garten, Alexander I. Klimov, Larisa V. Gubareva
  • Free
    Antiviral Agents
    Laninamivir Prodrug CS-8958, a Long-Acting Neuraminidase Inhibitor, Shows Superior Anti-Influenza Virus Activity after a Single Administration
    Shuku Kubo, Takanori Tomozawa, Masayo Kakuta, Akane Tokumitsu, Makoto Yamashita
  • Antiviral Agents
    Validation of the INNO-LiPA HBV DR Assay (Version 2) in Monitoring Hepatitis B Virus-Infected Patients Receiving Nucleoside Analog Treatment
    H. G. M. Niesters, F. Zoulim, C. Pichoud, M. Buti, F. Shapiro, N. D'Heuvaert, L. Celis, J. Doutreloigne, E. Sablon
  • Antiviral Agents
    InVitro and In Vivo Activities of the Novel Anticytomegalovirus Compound AIC246
    Peter Lischka, Guy Hewlett, Tobias Wunberg, Judith Baumeister, Daniela Paulsen, Thomas Goldner, Helga Ruebsamen-Schaeff, Holger Zimmermann
  • Antiviral Agents
    Identification of Novel Human Immunodeficiency Virus Type 1-Inhibitory Peptides Based on the Antimicrobial Peptide Database
    Guangshun Wang, Karen M. Watson, Alan Peterkofsky, Robert W. Buckheit
  • Antiviral Agents
    Effectiveness of Hand Sanitizers with and without Organic Acids for Removal of Rhinovirus from Hands
    Ronald B. Turner, Janice L. Fuls, Nancy D. Rodgers

Experimental Therapeutics

  • Experimental Therapeutics
    Early Curative Applications of the Aminoglycoside WR279396 on an Experimental Leishmania major-Loaded Cutaneous Site Do Not Impair the Acquisition of Immunity
    Hervé Lecoeur, Pierre A. Buffet, Geneviève Milon, Thierry Lang
  • Experimental Therapeutics
    Activity of Dalbavancin against Bacillus anthracis In Vitro and in a Mouse Inhalation Anthrax Model
    Henry S. Heine, Bret K. Purcell, Jennifer Bassett, Lynda Miller, Beth P. Goldstein
  • Experimental Therapeutics
    Efficacy of Posaconazole as Treatment and Prophylaxis against Fusarium solani
    Nathan P. Wiederhold, Laura K. Najvar, Rosie Bocanegra, John R. Graybill, Thomas F. Patterson
  • Experimental Therapeutics
    Rapamycin Protects Mice from Staphylococcal Enterotoxin B-Induced Toxic Shock and Blocks Cytokine Release InVitro and In Vivo
    Teresa Krakauer, Marilyn Buckley, Haleem J. Issaq, Stephen D. Fox
  • Experimental Therapeutics
    Efficacy of Rifampin and Its Combinations with Imipenem, Sulbactam, and Colistin in Experimental Models of Infection Caused by Imipenem-Resistant Acinetobacter baumannii
    María E. Pachón-Ibáñez, Fernando Docobo-Pérez, Rafael López-Rojas, Juan Domínguez-Herrera, Manuel E. Jiménez-Mejias, Andrés García-Curiel, Cristina Pichardo, Luis Jiménez, Jerónimo Pachón
  • Experimental Therapeutics
    Synergistic Antimicrobial Activities of Folic Acid Antagonists and Nucleoside Analogs
    Johannes Zander, Silke Besier, Hanns Ackermann, Thomas A. Wichelhaus
  • Experimental Therapeutics
    Comparative Pharmacodynamics of Amphotericin B Lipid Complex and Liposomal Amphotericin B in a Murine Model of Pulmonary Mucormycosis
    Russell E. Lewis, Nathan D. Albert, Guangling Liao, Jingguo Hou, Randall A. Prince, Dimitrios P. Kontoyiannis
  • Experimental Therapeutics
    Evaluation of New Thiazolide/Thiadiazolide Derivatives Reveals Nitro Group-Independent Efficacy against In Vitro Development of Cryptosporidium parvum
    Gilles Gargala, Laetitia Le Goff, Jean-Jacques Ballet, Loic Favennec, Andrew V. Stachulski, Jean-François Rossignol

Mechanisms of Resistance

  • Mechanisms of Resistance
    Evidence of Selective Sweeps in Genes Conferring Resistance to Chloroquine and Pyrimethamine in Plasmodium falciparum Isolates in India
    Tonya Mixson-Hayden, Vidhan Jain, Andrea M. McCollum, Amanda Poe, Avinash C. Nagpal, Aditya P. Dash, Jonathan K. Stiles, Venkatachalam Udhayakumar, Neeru Singh
  • Mechanisms of Resistance
    Single Nucleotide Polymorphism Analysis of the Major Tripartite Multidrug Efflux Pump of Escherichia coli: Functional Conservation in Disparate Animal Reservoirs despite Exposure to Antimicrobial Chemotherapy
    Christopher A. Elkins, Lisa B. Mullis, David W. Lacher, Carina M. Jung
  • Mechanisms of Resistance
    Spread of a Chromosomal Cefixime-Resistant penA Gene among Different Neisseria gonorrhoeae Lineages
    Makoto Ohnishi, Yuko Watanabe, Emi Ono, Chieko Takahashi, Hitomi Oya, Toshiro Kuroki, Ken Shimuta, Norio Okazaki, Shu-ichi Nakayama, Haruo Watanabe
  • Mechanisms of Resistance
    Selection of Mutations To Detect Multidrug-Resistant Mycobacterium tuberculosis Strains in Shanghai, China
    Tao Luo, Ming Zhao, Xia Li, Peng Xu, Xiaohong Gui, Sam Pickerill, Kathryn DeRiemer, Jian Mei, Qian Gao
  • Mechanisms of Resistance
    Delineation of a Bacterial Starvation Stress Response Network Which Can Mediate Antibiotic Tolerance Development
    Danny K. C. Fung, Edward W. C. Chan, Miu L. Chin, Raphael C. Y. Chan
  • Mechanisms of Resistance
    Impact of Azithromycin Resistance Mutations on the Virulence and Fitness of Chlamydia caviae in Guinea Pigs
    Rachel Binet, Anne K. Bowlin, Anthony T. Maurelli, Roger G. Rank
  • Mechanisms of Resistance
    Penicillin-Binding Protein Gene Alterations in Streptococcus uberis Isolates Presenting Decreased Susceptibility to Penicillin
    Marisa Haenni, Laure Galofaro, Mathilde Ythier, Marlyse Giddey, Paul Majcherczyk, Philippe Moreillon, Jean-Yves Madec
  • Mechanisms of Resistance
    Prevalence, Resistance Mechanisms, and Susceptibility of Multidrug-Resistant Bloodstream Isolates of Pseudomonas aeruginosa
    Vincent H. Tam, Kai-Tai Chang, Kamilia Abdelraouf, Cristina G. Brioso, Magdalene Ameka, Laurie A. McCaskey, Jaye S. Weston, Juan-Pablo Caeiro, Kevin W. Garey
  • Mechanisms of Resistance
    Combined ramR Mutation and Presence of a Tn1721-Associated tet(A) Variant in a Clinical Isolate of Salmonella enterica Serovar Hadar Resistant to Tigecycline
    M. Hentschke, M. Christner, I. Sobottka, M. Aepfelbacher, H. Rohde
  • Mechanisms of Resistance
    High Prevalence of ST131 Isolates Producing CTX-M-15 and CTX-M-14 among Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates from Canada
    Gisele Peirano, David Richardson, Jana Nigrin, Allison McGeer, Vivian Loo, Baldwin Toye, Michelle Alfa, Colette Pienaar, Pamela Kibsey, Johann D. D. Pitout
  • Mechanisms of Resistance
    GES-13, a β-Lactamase Variant Possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa
    S. D. Kotsakis, C. C. Papagiannitsis, E. Tzelepi, N. J. Legakis, V. Miriagou, L. S. Tzouvelekis
  • Mechanisms of Resistance
    Resistance to Linezolid in a Porcine Clostridium perfringens Strain Carrying a Mutation in the rplD Gene Encoding the Ribosomal Protein L4
    Christina S. Hölzel, Katrin S. Harms, Karin Schwaiger, Johann Bauer
  • Mechanisms of Resistance
    Detection of KPC in Acinetobacter spp. in Puerto Rico
    Iraida E. Robledo, Edna E. Aquino, María I. Santé, Jorge L. Santana, Diana M. Otero, Carlos F. León, Guillermo J. Vázquez
  • Mechanisms of Resistance
    Spread of OXA-48-Encoding Plasmid in Turkey and Beyond
    Amélie Carrër, Laurent Poirel, Mesut Yilmaz, Özay Arikan Akan, Cilli Feriha, Gaëlle Cuzon, Ghassan Matar, Patrick Honderlick, Patrice Nordmann

Susceptibility

  • Susceptibility
    Epidemiology of Invasive Meningococcal Disease with Decreased Susceptibility to Penicillin in Ontario, Canada, 2000 to 2006
    Elizabeth M. Brown, David N. Fisman, Steven J. Drews, Sharon Dolman, Prasad Rawte, Shirley Brown, Frances Jamieson
  • Susceptibility
    Rates and Mechanisms of Resistance Development in Mycobacterium tuberculosis to a Novel Diarylquinoline ATP Synthase Inhibitor
    E. Huitric, P. Verhasselt, A. Koul, K. Andries, S. Hoffner, D. I. Andersson
  • Susceptibility
    Distribution of Serotypes, Genotypes, and Resistance Determinants among Macrolide-Resistant Streptococcus pneumoniae Isolates
    Xiaoping Xu, Lin Cai, Meng Xiao, Fanrong Kong, Shahin Oftadeh, Fei Zhou, Gwendolyn L. Gilbert
  • Susceptibility
    Surveillance and Correlation of Antibiotic Prescription and Resistance of Gram-Negative Bacteria in Singaporean Hospitals
    Li-Yang Hsu, Thean-Yen Tan, Vincent H. Tam, Andrea Kwa, Dale Andrew Fisher, Tse-Hsien Koh
    and the Network for Antimicrobial Resistance Surveillance (Singapore)
  • Susceptibility
    Exploiting the Drug-Activating Properties of a Novel Trypanosomal Nitroreductase
    Belinda S. Hall, Xinghua Wu, Longqin Hu, Shane R. Wilkinson
  • Susceptibility
    In Vitro Sensitivities of Plasmodium falciparum to Different Antimalarial Drugs in Uganda
    Samuel L. Nsobya, Moses Kiggundu, Sarah Nanyunja, Moses Joloba, Bryan Greenhouse, Philip J. Rosenthal
  • Susceptibility
    Activity of a New Cephalosporin, CXA-101 (FR264205), against β-Lactam-Resistant Pseudomonas aeruginosa Mutants Selected In Vitro and after Antipseudomonal Treatment of Intensive Care Unit Patients
    Bartolome Moya, Laura Zamorano, Carlos Juan, José L. Pérez, Yigong Ge, Antonio Oliver
  • Susceptibility
    Antimicrobial Susceptibilities of Multidrug-Resistant Campylobacter jejuni and C. coli Strains: In Vitro Activities of 20 Antimicrobial Agents
    Mirva Lehtopolku, Ulla-Maija Nakari, Pirkko Kotilainen, Pentti Huovinen, Anja Siitonen, Antti J. Hakanen
  • Susceptibility
    Comparative In Vitro Activities of Nemonoxacin (TG-873870), a Novel Nonfluorinated Quinolone, and Other Quinolones against Clinical Isolates
    Tsai-Ling Lauderdale, Yih-Ru Shiau, Jui-Fen Lai, Hua-Chien Chen, Chi-Hsin R. King
  • Susceptibility
    Comparison of Anidulafungin MICs Determined by the Clinical and Laboratory Standards Institute Broth Microdilution Method (M27-A3 Document) and Etest for Candida Species Isolates
    Ana Espinel-Ingroff, E. Canton, J. Peman, E. Martín-Mazuelo
  • Susceptibility
    In Vitro Activity of CEM-101, a New Fluoroketolide Antibiotic, against Chlamydia trachomatis and Chlamydia (Chlamydophila) pneumoniae
    Patricia M. Roblin, Stephan A. Kohlhoff, Charles Parker, Margaret R. Hammerschlag
  • Susceptibility
    Acquisition of Flucytosine, Azole, and Caspofungin Resistance in Candida glabrata Bloodstream Isolates Serially Obtained from a Hematopoietic Stem Cell Transplant Recipient
    Florence Chapeland-Leclerc, Christophe Hennequin, Nicolas Papon, Thierry Noël, Aurélie Girard, Gérard Socié, Patricia Ribaud, Claire Lacroix
  • Susceptibility
    Trailing or Paradoxical Growth of Candida albicans When Exposed to Caspofungin Is Not Associated with Microsatellite Genotypes
    Mohamed Khlif, Hervé Bogreau, Annie Michel-Nguyen, Ali Ayadi, Stéphane Ranque

Mechanisms of Action

  • Mechanisms of Action: Physiological Effects
    Acinetobacter baumannii Increases Tolerance to Antibiotics in Response to Monovalent Cations
    M. Indriati Hood, Anna C. Jacobs, Khalid Sayood, Paul M. Dunman, Eric P. Skaar
  • Mechanisms of Action: Physiological Effects
    Probing the Antimalarial Mechanism of Artemisinin and OZ277 (Arterolane) with Nonperoxidic Isosteres and Nitroxyl Radicals
    Matthias A. Fügi, Sergio Wittlin, Yuxiang Dong, Jonathan L. Vennerstrom
  • Mechanisms of Action: Physiological Effects
    Constitutive SoxS Expression in a Fluoroquinolone-Resistant Strain with a Truncated SoxR Protein and Identification of a New Member of the marA-soxS-rob Regulon, mdtG
    Anna Fàbrega, Robert G. Martin, Judah L. Rosner, M. Mar Tavio, Jordi Vila
  • Mechanisms of Action: Physiological Effects
    Inhibition of Porphyromonas gingivalis Biofilm by Oxantel
    Stuart Dashper, Ching-Seng Ang, Sze Wei Liu, Rita Paolini, Paul Veith, Eric Reynolds
  • Mechanisms of Action: Physiological Effects
    Antimalarial Asexual Stage-Specific and Gametocytocidal Activities of HIV Protease Inhibitors
    Christopher L. Peatey, Katherine T. Andrews, Nina Eickel, Timothy MacDonald, Alice S. Butterworth, Katharine R. Trenholme, Donald L. Gardiner, James S. McCarthy, Tina S. Skinner-Adams
  • Mechanisms of Action: Physiological Effects
    Antibacterial Activity of N-Pentylpantothenamide Is Due to Inhibition of Coenzyme A Synthesis
    Jacob Thomas, John E. Cronan

Pharmacology

  • Pharmacology
    Pharmacokinetics of Antituberculosis Drugs in Pulmonary Tuberculosis Patients with Type 2 Diabetes
    Rovina Ruslami, Hanneke M. J. Nijland, I. Gusti N. Adhiarta, Sri H. K. S. Kariadi, Bachti Alisjahbana, Rob E. Aarnoutse, Reinout van Crevel
  • Pharmacology
    Clinical Pharmacodynamics of Cefepime in Patients Infected with Pseudomonas aeruginosa
    Jared L. Crandon, Catharine C. Bulik, Joseph L. Kuti, David P. Nicolau
  • Pharmacology
    Elucidation of the Pharmacokinetic/Pharmacodynamic Determinant of Colistin Activity against Pseudomonas aeruginosa in Murine Thigh and Lung Infection Models
    Rajesh V. Dudhani, John D. Turnidge, Kingsley Coulthard, Robert W. Milne, Craig R. Rayner, Jian Li, Roger L. Nation
  • Pharmacology
    Pharmacokinetics of Acyclovir and Its Metabolites in Cerebrospinal Fluid and Systemic Circulation after Administration of High-Dose Valacyclovir in Subjects with Normal and Impaired Renal Function
    James P. Smith, Stephen Weller, Benjamin Johnson, Janet Nicotera, James M. Luther, David W. Haas
  • Pharmacology
    Pharmacokinetic-Pharmacodynamic Modeling of Alpha Interferon Response Induced by a Toll-Like 7 Receptor Agonist in Mice
    Neil Benson, Joost de Jongh, Jonathan D. Duckworth, Hannah M. Jones, Henry E. Pertinez, Jaiessh K. Rawal, Tamara J. van Steeg, Piet H. Van der Graaf
  • Pharmacology
    Pharmacokinetics of Chloroquine and Monodesethylchloroquine in Pregnancy
    Harin A. Karunajeewa, Sam Salman, Ivo Mueller, Francisca Baiwog, Servina Gomorrai, Irwin Law, Madhu Page-Sharp, Stephen Rogerson, Peter Siba, Kenneth F. Ilett, Timothy M. E. Davis
  • Pharmacology
    Impact of Different Factors on the Probability of Clinical Response in Tigecycline-Treated Patients with Intra-Abdominal Infections
    S. M. Bhavnani, C. M. Rubino, P. G. Ambrose, T. J. Babinchak, J. M. Korth-Bradley, G. L. Drusano
  • Pharmacology
    Clinical Pharmacokinetics of Oral Controlled-Release 5-Fluorocytosine
    Manjunath P. Pai, Hollie Bruce, Linda A. Felton
  • Pharmacology
    Early Viral Kinetics of Telbivudine and Entecavir: Results of a 12-Week Randomized Exploratory Study with Patients with HBeAg-Positive Chronic Hepatitis B
    Dong Jin Suh, Soon Ho Um, Eva Herrmann, Ju-Hyun Kim, Young Sok Lee, Heon Ju Lee, Myung Seok Lee, Youn-Jae Lee, Weibin Bao, Patricia Lopez, Han Chu Lee, Claudio Avila, Stefan Zeuzem
  • Pharmacology
    Lack of Pharmacokinetic Interaction between Amdoxovir and Reduced- and Standard-Dose Zidovudine in HIV-1-Infected Individuals
    Selwyn J. Hurwitz, Ghazia Asif, Emilie Fromentin, Phillip M. Tharnish, Raymond F. Schinazi
  • Pharmacology
    Population Pharmacokinetic Comparison and Pharmacodynamic Breakpoints of Ceftazidime in Cystic Fibrosis Patients and Healthy Volunteers
    J. B. Bulitta, C. B. Landersdorfer, S. J. Hüttner, G. L. Drusano, M. Kinzig, U. Holzgrabe, U. Stephan, F. Sörgel
  • Pharmacology
    Effects of Immunomodulatory and Organism-Associated Molecules on the Permeability of an In Vitro Blood-Brain Barrier Model to Amphotericin B and Fluconazole
    Vasilios Pyrgos, Diane Mickiene, Tin Sein, Margaret Cotton, Andrea Fransesconi, Isaac Mizrahi, Martha Donoghue, Nikkida Bundrant, Su-Young Kim, Matthew Hardwick, Shmuel Shoham, Thomas J. Walsh
  • Pharmacology
    Attenuation of Cerebrospinal Fluid Inflammation by the Nonbacteriolytic Antibiotic Daptomycin versus That by Ceftriaxone in Experimental Pneumococcal Meningitis
    Denis Grandgirard, Kevin Oberson, Angela Bühlmann, Rahel Gäumann, Stephen L. Leib

Chemistry; Biosynthesis

  • Chemistry; Biosynthesis
    Molecular Cloning and Heterologous Expression of a Biosynthetic Gene Cluster for the Antitubercular Agent d-Cycloserine Produced by Streptomyces lavendulae
    Takanori Kumagai, Yusuke Koyama, Kosuke Oda, Masafumi Noda, Yasuyuki Matoba, Masanori Sugiyama

Clinical Therapeutics

  • Clinical Therapeutics
    Amodiaquine Dosage and Tolerability for Intermittent Preventive Treatment To Prevent Malaria in Children
    M. Cairns, B. Cisse, C. Sokhna, C. Cames, K. Simondon, E. H. Ba, J.-F. Trape, O. Gaye, B. M. Greenwood, P. J. M. Milligan

Analytical Procedures

  • Analytical Procedures
    aac(6′)-Ib-cr Genotyping by Simultaneous High-Resolution Melting Analyses of an Unlabeled Probe and Full-Length Amplicon
    Jan M. Bell, John D. Turnidge, Patiyan Andersson

Letters

  • Letter to the Editor
    Full Resistance and Decreased Susceptibility to Carbapenems in IMP-13-Producing Pseudomonas aeruginosa Isolates from an Outbreak
    Gisela Santella, Arabela Cuirolo, Marisa Almuzara, Susana Palombarani, Gabriela Sly, Marcela Radice, Gabriel Gutkind

Author's Correction

  • AUTHOR'S CORRECTION
    Evaluation of Vancomycin and Daptomycin Potency Trends (MIC Creep) against Methicillin-Resistant Staphylococcus aureus Isolates Collected in Nine U.S. Medical Centers from 2002 to 2006
    Helio S. Sader, Paul D. Fey, Ajit P. Limaye, Nancy Madinger, George Pankey, James Rahal, Michael J. Rybak, David R. Snydman, Lisa L. Steed, Ken Waites, Ronald N. Jones
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Antimicrobial Agents and Chemotherapy: 54 (3)

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volume 54, issue 3
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  • Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2
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