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Experimental Therapeutics

Lipophilic Bisphosphonates Are Potent Inhibitors of Plasmodium Liver-Stage Growth

Agam Prasad Singh, Yonghui Zhang, Joo-Hwan No, Roberto Docampo, Victor Nussenzweig, Eric Oldfield
Agam Prasad Singh
1National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
2Department of Pathology, New York University, Langone Medical Center, 550 First Avenue, New York, New York 10016
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  • For correspondence: singhap@nii.res.in eo@chad.scs.uiuc.edu
Yonghui Zhang
3Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801
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Joo-Hwan No
4Center for Biophysics and Computational Biology, 607 South Mathews Avenue, Urbana, Illinois 61801
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Roberto Docampo
5Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia
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Victor Nussenzweig
2Department of Pathology, New York University, Langone Medical Center, 550 First Avenue, New York, New York 10016
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Eric Oldfield
3Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801
4Center for Biophysics and Computational Biology, 607 South Mathews Avenue, Urbana, Illinois 61801
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  • For correspondence: singhap@nii.res.in eo@chad.scs.uiuc.edu
DOI: 10.1128/AAC.00198-10
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Article Information

DOI 
https://doi.org/10.1128/AAC.00198-10
PubMed 
20457823

Published By 
American Society for Microbiology Journals
History 
  • Received February 11, 2010
  • Returned for modification March 18, 2010
  • Accepted April 27, 2010
  • Published online June 16, 2010.

Copyright & Usage 
Copyright © 2010 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (May 10, 2010).
  • You are viewing the most recent version of this article.

Author Information

  1. Agam Prasad Singh1,2*,
  2. Yonghui Zhang3,
  3. Joo-Hwan No4,
  4. Roberto Docampo5,
  5. Victor Nussenzweig2 and
  6. Eric Oldfield3,4*
  1. 1National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India
  2. 2Department of Pathology, New York University, Langone Medical Center, 550 First Avenue, New York, New York 10016
  3. 3Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801
  4. 4Center for Biophysics and Computational Biology, 607 South Mathews Avenue, Urbana, Illinois 61801
  5. 5Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia
  • ↵* Corresponding author. Mailing address for Agam Prasad Singh: National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India. Phone: 91-11-26703707. Fax: 91-11-26717104. E-mail: singhap{at}nii.res.in . Mailing address for Eric Oldfield: A110 Chemical & Life Science Lab, 600 South Mathews Avenue, Urbana, IL 61801. Phone: (217) 333-3374. Fax: (217) 244-0997. E-mail: eo{at}chad.scs.uiuc.edu
  • † Supplemental material for this article may be found at http://aac.asm.org/ .

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Lipophilic Bisphosphonates Are Potent Inhibitors of Plasmodium Liver-Stage Growth
Agam Prasad Singh, Yonghui Zhang, Joo-Hwan No, Roberto Docampo, Victor Nussenzweig, Eric Oldfield
Antimicrobial Agents and Chemotherapy Jun 2010, 54 (7) 2987-2993; DOI: 10.1128/AAC.00198-10

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Lipophilic Bisphosphonates Are Potent Inhibitors of Plasmodium Liver-Stage Growth
Agam Prasad Singh, Yonghui Zhang, Joo-Hwan No, Roberto Docampo, Victor Nussenzweig, Eric Oldfield
Antimicrobial Agents and Chemotherapy Jun 2010, 54 (7) 2987-2993; DOI: 10.1128/AAC.00198-10
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KEYWORDS

antimalarials
Diphosphonates
Liver
Plasmodium berghei

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