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Mechanisms of Resistance

In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya

John Okombo, Steven M. Kiara, Josea Rono, Leah Mwai, Lewa Pole, Eric Ohuma, Steffen Borrmann, Lynette Isabella Ochola, Alexis Nzila
John Okombo
1Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kilifi, Kenya
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Steven M. Kiara
1Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kilifi, Kenya
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Josea Rono
1Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kilifi, Kenya
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Leah Mwai
1Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kilifi, Kenya
2 University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
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Lewa Pole
1Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kilifi, Kenya
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Eric Ohuma
1Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kilifi, Kenya
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Steffen Borrmann
1Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kilifi, Kenya
3Institute of Hygiene, University of Heidelberg School of Medicine, Heidelberg, Germany
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Lynette Isabella Ochola
1Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kilifi, Kenya
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Alexis Nzila
1Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kilifi, Kenya
2 University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
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  • For correspondence: anzila@kilifi.kemri-wellcome.org
DOI: 10.1128/AAC.00325-10
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Article Information

DOI 
https://doi.org/10.1128/AAC.00325-10
PubMed 
20516285

Published By 
American Society for Microbiology Journals
History 
  • Received March 9, 2010
  • Returned for modification April 25, 2010
  • Accepted May 23, 2010
  • Published online July 15, 2010.

Copyright & Usage 
Copyright © 2010 American Society for Microbiology

Article Versions

  • Accepted Manuscript version (June 01, 2010).
  • You are viewing the most recent version of this article.

Author Information

  1. John Okombo1,
  2. Steven M. Kiara1,
  3. Josea Rono1,
  4. Leah Mwai1,2,
  5. Lewa Pole1,
  6. Eric Ohuma1,
  7. Steffen Borrmann1,3,
  8. Lynette Isabella Ochola1 and
  9. Alexis Nzila1,2*
  1. 1Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kilifi, Kenya
  2. 2 University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
  3. 3Institute of Hygiene, University of Heidelberg School of Medicine, Heidelberg, Germany
  • ↵* Corresponding author. Mailing address: Kenya Medical Research Institute (KEMRI)/Wellcome Trust Collaborative Research Program, P.O. Box 230, 80108 Kilifi, Kenya. Phone: 254-41-522535. Fax: 254-41-522390. E-mail: anzila{at}kilifi.kemri-wellcome.org

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In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya
John Okombo, Steven M. Kiara, Josea Rono, Leah Mwai, Lewa Pole, Eric Ohuma, Steffen Borrmann, Lynette Isabella Ochola, Alexis Nzila
Antimicrobial Agents and Chemotherapy Jul 2010, 54 (8) 3302-3307; DOI: 10.1128/AAC.00325-10

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In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya
John Okombo, Steven M. Kiara, Josea Rono, Leah Mwai, Lewa Pole, Eric Ohuma, Steffen Borrmann, Lynette Isabella Ochola, Alexis Nzila
Antimicrobial Agents and Chemotherapy Jul 2010, 54 (8) 3302-3307; DOI: 10.1128/AAC.00325-10
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KEYWORDS

antimalarials
Plasmodium falciparum
Polymorphism, Genetic
Quinine
Sodium-Hydrogen Exchangers

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