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Table of Contents

January 2011; Volume 55,Issue 1

Instructions To Authors

  • Free
    INSTRUCTIONS TO AUTHORS
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Minireviews

  • Minireview
    An Oracle: Antituberculosis Pharmacokinetics-Pharmacodynamics, Clinical Correlation, and Clinical Trial Simulations To Predict the Future
    Jotam Pasipanodya, Tawanda Gumbo

Antiviral Agents

  • Antiviral Agents
    Oral Hexadecyloxypropyl-Cidofovir Therapy in Pregnant Guinea Pigs Improves Outcome in the Congenital Model of Cytomegalovirus Infection
    Fernando J. Bravo, David I. Bernstein, James R. Beadle, Karl Y. Hostetler, Rhonda D. Cardin
  • Antiviral Agents
    Identification and Characterization of Persistent Intracellular Human Immunodeficiency Virus Type 1 Integrase Strand Transfer Inhibitor Activity
    Yasuhiro Koh, Hillel Haim, Alan Engelman
  • Open Access
    Antiviral Agents
    Safety and Pharmacokinetics of IDX184, a Liver-Targeted Nucleotide Polymerase Inhibitor of Hepatitis C Virus, in Healthy Subjects
    Xiao-Jian Zhou, Keith Pietropaolo, Jie Chen, Samina Khan, John Sullivan-Bólyai, Douglas Mayers
  • Antiviral Agents
    Novel Dengue Virus-Specific NS2B/NS3 Protease Inhibitor, BP2109, Discovered by a High-Throughput Screening Assay
    Chi-Chen Yang, Yi-Chen Hsieh, Shiow-Ju Lee, Szu-Huei Wu, Ching-Len Liao, Chang-Huei Tsao, Yu-Sheng Chao, Jyh-Haur Chern, Chung-Pu Wu, Andrew Yueh
  • Antiviral Agents
    Novel Compounds Containing Multiple Guanide Groups That Bind the HIV Coreceptor CXCR4
    Royce A. Wilkinson, Seth H. Pincus, Joyce B. Shepard, Sarah K. Walton, Edward P. Bergin, Mohamed Labib, Martin Teintze
  • Antiviral Agents
    Potent Strategy To Inhibit HIV-1 by Binding both gp120 and gp41
    Ioannis Kagiampakis, Arbi Gharibi, Marie K. Mankowski, Beth A. Snyder, Roger G. Ptak, Kristabelle Alatas, Patricia J. LiWang
  • Antiviral Agents
    Pre-Steady-State Kinetic Analysis of the Incorporation of Anti-HIV Nucleotide Analogs Catalyzed by Human X- and Y-Family DNA Polymerases
    Jessica A. Brown, Lindsey R. Pack, Jason D. Fowler, Zucai Suo
  • Antiviral Agents
    Cross-Resistance Profile Determination of Two Second-Generation HIV-1 Integrase Inhibitors Using a Panel of Recombinant Viruses Derived from Raltegravir-Treated Clinical Isolates
    L. Van Wesenbeeck, E. Rondelez, M. Feyaerts, A. Verheyen, K. Van der Borght, V. Smits, C. Cleybergh, H. De Wolf, K. Van Baelen, L. J. Stuyver
  • Antiviral Agents
    Population Pharmacokinetics of Nevirapine in HIV-1-Infected Pregnant Women and Their Neonates
    Sihem Benaboud, Didier K. Ekouévi, Saik Urien, Elisabeth Rey, Elise Arrivé, Stéphane Blanche, Glenda Gray, Kruy Leang Sim, Divine Avit, James McIntyre, Eric Nerrienet, François Dabis, Jean-Marc Tréluyer, Déborah Hirt
    and the TEmAA ANRS 12109 Study Group
  • Antiviral Agents
    Cytomegalovirus UL97 Mutations Affecting Cyclopropavir and Ganciclovir Susceptibility
    Sunwen Chou, Terry L. Bowlin
  • Antiviral Agents
    High Levels and Safety of Oseltamivir Carboxylate Plasma Concentrations after Nasogastric Administration in Critically Ill Children in a Pediatric Intensive Care Unit
    Carole Giraud, Sandra Manceau, Mehdi Oualha, Hélène Chappuy, Agnès Mogenet, Patrick Duchêne, Sarah Ducrocq, Philippe Hubert, Jean M. Treluyer

Mechanisms of Action

  • Mechanisms of Action: Physiological Effects
    Genetic Predisposition Favors the Acquisition of Stable Artemisinin Resistance in Malaria Parasites
    Dorothee Beez, Cecilia P. Sanchez, Wilfred D. Stein, Michael Lanzer
  • Mechanisms of Action: Physiological Effects
    Differential Effects of Paromomycin on Ribosomes of Leishmania mexicana and Mammalian Cells
    Marisa M. Fernández, Emilio L. Malchiodi, Israel D. Algranati
  • Mechanisms of Action: Physiological Effects
    Profiling the Aspergillus fumigatus Proteome in Response to Caspofungin
    Steven E. Cagas, Mohit Raja Jain, Hong Li, David S. Perlin
  • Mechanisms of Action: Physiological Effects
    Functional Antibodies Targeting IsaA of Staphylococcus aureus Augment Host Immune Response and Open New Perspectives for Antibacterial Therapy
    Udo Lorenz, Birgit Lorenz, Tim Schmitter, Karin Streker, Christian Erck, Jürgen Wehland, Joachim Nickel, Bastian Zimmermann, Knut Ohlsen
  • Mechanisms of Action: Physiological Effects
    Novel Insights into the Mode of Inhibition of Class A SHV-1 β-Lactamases Revealed by Boronic Acid Transition State Inhibitors
    Wei Ke, Jared M. Sampson, Claudia Ori, Fabio Prati, Sarah M. Drawz, Christopher R. Bethel, Robert A. Bonomo, Focco van den Akker
  • Mechanisms of Action: Physiological Effects
    Amiodarone Inhibits Trypanosoma cruzi Infection and Promotes Cardiac Cell Recovery with Gap Junction and Cytoskeleton Reassembly In Vitro
    Daniel Adesse, Eduardo Meirelles Azzam, Maria de Nazareth L. Meirelles, Julio A. Urbina, Luciana R. Garzoni
  • Mechanisms of Action: Physiological Effects
    Structural Features Governing the Activity of Lactoferricin-Derived Peptides That Act in Synergy with Antibiotics against Pseudomonas aeruginosa In Vitro and In Vivo
    Susana Sánchez-Gómez, Bostjan Japelj, Roman Jerala, Ignacio Moriyón, Mirian Fernández Alonso, José Leiva, Sylvie E. Blondelle, Jörg Andrä, Klaus Brandenburg, Karl Lohner, Guillermo Martínez de Tejada
  • Mechanisms of Action: Physiological Effects
    The Antibiotic Gentamicin Inhibits Specific Protein Trafficking Functions of the Arf1/2 Family of GTPases
    Lin Lin, Mark C. Wagner, Ross Cocklin, Alex Kuzma, Maureen Harrington, Bruce A. Molitoris, Mark G. Goebl
  • Mechanisms of Action: Physiological Effects
    Structure of the Mycobacterium tuberculosis d-Alanine:d-Alanine Ligase, a Target of the Antituberculosis Drug d-Cycloserine
    John B. Bruning, Ana C. Murillo, Ofelia Chacon, Raúl G. Barletta, James C. Sacchettini
  • Mechanisms of Action: Physiological Effects
    Mode-of-Action Studies of the Novel Bisquaternary Bisnaphthalimide MT02 against Staphylococcus aureus
    Thomas M. Menzel, Maximilian Tischer, Patrice François, Joachim Nickel, Jacques Schrenzel, Heike Bruhn, Annette Albrecht, Leane Lehmann, Ulrike Holzgrabe, Knut Ohlsen
  • Mechanisms of Action: Physiological Effects
    Flow Cytometry as a Tool To Determine the Effects of Cell Wall-Active Antibiotics on Vancomycin-Susceptible and -Resistant Enterococcus faecalis Strains
    Françoise Chau, Agnès Lefort, Samira Benadda, Vincent Dubée, Bruno Fantin
  • Mechanisms of Action: Physiological Effects
    Cold Shock Induces qnrA Expression in Shewanella algae
    Hong Bin Kim, Chi Hye Park, Mariah Gavin, George A. Jacoby, David C. Hooper
  • Mechanisms of Action: Physiological Effects
    Short Alkylated Peptoid Mimics of Antimicrobial Lipopeptides
    Nathaniel P. Chongsiriwatana, Tyler M. Miller, Modi Wetzler, Sergei Vakulenko, Amy J. Karlsson, Sean P. Palecek, Shahriar Mobashery, Annelise E. Barron
  • Mechanisms of Action: Physiological Effects
    Effect of Antibiotic Treatment on Bacteriophage Production by a Cystic Fibrosis Epidemic Strain of Pseudomonas aeruginosa
    Joanne L. Fothergill, Eilidh Mowat, Martin J. Walshaw, Martin J. Ledson, Chloe E. James, Craig Winstanley
  • Mechanisms of Action: Physiological Effects
    Inhibition of Bacterial Multidrug Resistance by Celecoxib, a Cyclooxygenase-2 Inhibitor
    Arunasree M. Kalle, Arshad Rizvi

Experimental Therapeutics

  • Experimental Therapeutics
    Using Bioluminescence To Monitor Treatment Response in Real Time in Mice with Mycobacterium ulcerans Infection
    Tianyu Zhang, Si-Yang Li, Paul J. Converse, Deepak V. Almeida, Jacques H. Grosset, Eric L. Nuermberger
  • Experimental Therapeutics
    Evaluation of Ceftazidime and NXL104 in Two Murine Models of Infection Due to KPC-Producing Klebsiella pneumoniae
    Andrea Endimiani, Kristine M. Hujer, Andrea M. Hujer, Mark E. Pulse, William J. Weiss, Robert A. Bonomo
  • Experimental Therapeutics
    Activities of TMC207, Rifampin, and Pyrazinamide against Mycobacterium tuberculosis Infection in Guinea Pigs
    Shaobin Shang, Crystal A. Shanley, Megan L. Caraway, Eileen A. Orme, Marcela Henao-Tamayo, Laurel Hascall-Dove, David Ackart, Anne J. Lenaerts, Randall J. Basaraba, Ian M. Orme, Diane J. Ordway
  • Experimental Therapeutics
    Recombinant Anthrax Toxin Receptor-Fc Fusion Proteins Produced in Plants Protect Rabbits against Inhalational Anthrax
    Keith L. Wycoff, Archana Belle, Dorothée Deppe, Leah Schaefer, James M. Maclean, Simone Haase, Anke K. Trilling, Shihui Liu, Stephen H. Leppla, Isin N. Geren, Jennifer Pawlik, Johnny W. Peterson
  • Experimental Therapeutics
    PA-824 Exhibits Time-Dependent Activity in a Murine Model of Tuberculosis
    Zahoor Ahmad, Charles A. Peloquin, Rajendra P. Singh, Hartmut Derendorf, Sandeep Tyagi, Ann Ginsberg, Jacques H. Grosset, Eric L. Nuermberger
  • Experimental Therapeutics
    Anti-Inflammatory Benefits of Antibiotic-Induced Neutrophil Apoptosis: Tulathromycin Induces Caspase-3-Dependent Neutrophil Programmed Cell Death and Inhibits NF-κB Signaling and CXCL8 Transcription
    Carrie D. Fischer, Jennifer K. Beatty, Cheryl G. Zvaigzne, Douglas W. Morck, Merlyn J. Lucas, A. G. Buret
  • Experimental Therapeutics
    Failure of Vancomycin Continuous Infusion against Experimental Endocarditis Due to Vancomycin-Intermediate Staphylococcus aureus
    J. M. Entenza, T. R. Veloso, J. Vouillamoz, M. Giddey, P. Moreillon

Pharmacology

  • Pharmacology
    Immunocytochemistry for Amoxicillin and Its Use for Studying Uptake of the Drug in the Intestine, Liver, and Kidney of Rats
    Kunio Fujiwara, Masashi Shin, Tsubasa Miyazaki, Yasuhiro Maruta
  • Pharmacology
    Plasma and Intracellular (Peripheral Blood Mononuclear Cells) Pharmacokinetics of Once-Daily Raltegravir (800 Milligrams) in HIV-Infected Patients
    José Moltó, Marta Valle, David Back, Samandhy Cedeño, Victoria Watson, Neill Liptrott, Deirdre Egan, Cristina Miranda, Manuel J. Barbanoj, Bonaventura Clotet
  • Pharmacology
    Evaluation of Hepatotoxicity with Off-Label Oral-Treatment Doses of Voriconazole for Invasive Fungal Infections
    Elizabeth Gorski, John S. Esterly, Michael Postelnick, Steven Trifilio, Michael Fotis, Marc H. Scheetz
  • Pharmacology
    Herb-Drug Interaction between Echinacea purpurea and Darunavir-Ritonavir in HIV-Infected Patients
    José Moltó, Marta Valle, Cristina Miranda, Samandhy Cedeño, Eugenia Negredo, Manuel José Barbanoj, Bonaventura Clotet

Mechanisms of Resistance

  • Mechanisms of Resistance
    Spontaneous Mutations in the Plasmodium falciparum Sarcoplasmic/ Endoplasmic Reticulum Ca2+-ATPase (PfATP6) Gene among Geographically Widespread Parasite Populations Unexposed to Artemisinin-Based Combination Therapies
    Kazuyuki Tanabe, Sedigheh Zakeri, Nirianne Marie Q. Palacpac, Manada Afsharpad, Milijaona Randrianarivelojosia, Akira Kaneko, Aung Swi Prue Marma, Toshihiro Horii, Toshihiro Mita
  • Mechanisms of Resistance
    Contribution of Specific Amino Acid Changes in Penicillin Binding Protein 1 to Amoxicillin Resistance in Clinical Helicobacter pylori isolates
    Nadia N. Qureshi, Dimitrios Morikis, Neal L. Schiller
  • Mechanisms of Resistance
    Structural and Biochemical Analysis of the Pentapeptide Repeat Protein EfsQnr, a Potent DNA Gyrase Inhibitor
    Subray S. Hegde, Matthew W. Vetting, Lesley A. Mitchenall, Anthony Maxwell, John S. Blanchard
  • Mechanisms of Resistance
    Metallo-β-Lactamase Production by Pseudomonas otitidis: a Species-Related Trait
    Maria Cristina Thaller, Luisa Borgianni, Gustavo Di Lallo, Yunsop Chong, Kyungwon Lee, Joseph Dajcs, David Stroman, Gian Maria Rossolini
  • Mechanisms of Resistance
    Genetic Context and Biochemical Characterization of the IMP-18 Metallo-β-Lactamase Identified in a Pseudomonas aeruginosa Isolate from the United States
    Luisa Borgianni, Silvia Prandi, Laurie Salden, Gisela Santella, Nancy D. Hanson, Gian Maria Rossolini, Jean-Denis Docquier
  • Mechanisms of Resistance
    Tracking Origins and Spread of Sulfadoxine-Resistant Plasmodium falciparum dhps Alleles in Thailand
    Md Tauqeer Alam, Sumiti Vinayak, Kanungnit Congpuong, Chansuda Wongsrichanalai, Wichai Satimai, Laurence Slutsker, Ananias A. Escalante, John W. Barnwell, Venkatachalam Udhayakumar
  • Mechanisms of Resistance
    Overexpression of patA and patB, Which Encode ABC Transporters, Is Associated with Fluoroquinolone Resistance in Clinical Isolates of Streptococcus pneumoniae
    Mark I. Garvey, Alison J. Baylay, Ryan L. Wong, Laura J. V. Piddock
  • Mechanisms of Resistance
    Roles of Residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in Extended-Spectrum β-Lactamase Toho-1
    Akiko Shimizu-Ibuka, Mika Oishi, Shoko Yamada, Yoshikazu Ishii, Kiyoshi Mura, Hiroshi Sakai, Hiroshi Matsuzawa
  • Mechanisms of Resistance
    Changes in Cell Wall Synthesis and Ultrastructure during Paradoxical Growth Effect of Caspofungin on Four Different Candida Species
    Fernando C. Bizerra, Analy S. A. Melo, Eduardo Katchburian, Edna Freymüller, Anita H. Straus, Hélio K. Takahashi, Arnaldo L. Colombo
  • Mechanisms of Resistance
    Carbapenem-Hydrolyzing GES-Type Extended-Spectrum β-Lactamase in Acinetobacter baumannii
    Rémy A. Bonnin, Patrice Nordmann, Anaïs Potron, Hervé Lecuyer, Jean-Ralph Zahar, Laurent Poirel
  • Mechanisms of Resistance
    Molecular Investigation of Resistance to the Antituberculous Drug Ethionamide in Multidrug-Resistant Clinical Isolates of Mycobacterium tuberculosis
    F. Brossier, N. Veziris, C. Truffot-Pernot, V. Jarlier, W. Sougakoff
  • Mechanisms of Resistance
    A Novel Insertion Sequence, ISAba10, Inserted into ISAba1 Adjacent to the bla OXA-23 Gene and Disrupting the Outer Membrane Protein Gene carO in Acinetobacter baumannii
    Yangsoon Lee, Chang-Ki Kim, Hyukmin Lee, Seok Hoon Jeong, Dongeun Yong, Kyungwon Lee
  • Mechanisms of Resistance
    Regulation of mprF by Antisense RNA Restores Daptomycin Susceptibility to Daptomycin-Resistant Isolates of Staphylococcus aureus
    Aileen Rubio, Mary Conrad, Robert J. Haselbeck, Kedar G. C., Vickie Brown-Driver, John Finn, Jared A. Silverman
  • Mechanisms of Resistance
    New Species Genetic Approach To Identify Strains of Mitis Group Streptococci That Are Donors of Rifampin Resistance to Streptococcus pneumoniae
    María-José Ferrándiz, Carmen Ardanuy, Josefina Liñares, Luz Balsalobre, María Teresa García, Adela G. de la Campa
  • Mechanisms of Resistance
    Novel Apramycin Resistance Gene apmA in Bovine and Porcine Methicillin-Resistant Staphylococcus aureus ST398 Isolates
    Andrea T. Feßler, Kristina Kadlec, Stefan Schwarz
  • Mechanisms of Resistance
    Sequence of pR3521, an IncB Plasmid from Escherichia coli Encoding ACC-4, SCO-1, and TEM-1 β-Lactamases
    C. C. Papagiannitsis, L. S. Tzouvelekis, S. D. Kotsakis, E. Tzelepi, V. Miriagou
  • Mechanisms of Resistance
    Purification and Biochemical Characterization of IMP-13 Metallo-β-Lactamase
    Gisela Santella, Jean-Denis Docquier, Gabriel Gutkind, Gian Maria Rossolini, Marcela Radice
  • Mechanisms of Resistance
    Identification of Diverse OXA-40 Group Carbapenemases, Including a Novel Variant, OXA-160, from Acinetobacter baumannii in Pennsylvania
    Guo-Bao Tian, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Anthony W. Pasculle, John P. Quinn, Hong-Ning Wang, Yohei Doi
  • Mechanisms of Resistance
    Emergence of Klebsiella pneumoniae Coproducing KPC-2 and 16S rRNA Methylase ArmA in Poland
    Katarzyna Zacharczuk, Katarzyna Piekarska, Jolanta Szych, Elwira Zawidzka, Agnieszka Sulikowska, Sebastian Wardak, Marek Jagielski, Rafał Gierczyński

Clinical Therapeutics

  • Clinical Therapeutics
    In Vivo and In Vitro Efficacy of Chloroquine against Plasmodium malariae and P. ovale in Papua, Indonesia
    H. Siswantoro, B. Russell, A. Ratcliff, B. Prasetyorini, F. Chalfein, J. Marfurt, E. Kenangalem, M. Wuwung, K. A. Piera, E. P. Ebsworth, N. M. Anstey, E. Tjitra, R. N. Price
  • Clinical Therapeutics
    Systematic Review and Meta-Analysis of the Significance of Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Isolates
    Sebastiaan J. van Hal, David L. Paterson

Analytical Procedures

  • Analytical Procedures
    Sensitive In Vitro System To Assess Morphological and Biochemical Effects of Praziquantel and Albendazole on Taenia solium Cysts
    S. Mahanty, A. Paredes, M. Marzal, E. Gonzalez, S. Rodriguez, P. Dorny, C. Guerra-Giraldez, H. H. Garcia, T. Nash

Susceptibility

  • Susceptibility
    Polymyxin-Resistant Clinical Isolates of Escherichia coli
    Carl Urban, Hemavarna Tiruvury, Noriel Mariano, Rita Colon-Urban, James J. Rahal
  • Susceptibility
    Activities of NXL104 Combinations with Ceftazidime and Aztreonam against Carbapenemase-Producing Enterobacteriaceae
    David M. Livermore, Shazad Mushtaq, Marina Warner, Jiancheng Zhang, Sunil Maharjan, Michel Doumith, Neil Woodford
  • Susceptibility
    Prevalence and Mechanism of Resistance to Antimicrobial Agents in Group G Streptococcal Isolates from China
    Jun Yin, Sangjie Yu, Xiaorong Liu, Ye Li, Wei Gao, Xiang Ma, Yonghong Yang
  • Susceptibility
    Activity of Deferasirox in Mucorales: Influences of Species and Exogenous Iron
    Russell E. Lewis, Georgios N. Pongas, Nathaniel Albert, Ronen Ben-Ami, Thomas J. Walsh, Dimitrios P. Kontoyiannis
  • Susceptibility
    In Vitro Activity of Ceftaroline against a Broad Spectrum of Recent Clinical Anaerobic Isolates
    David R. Snydman, Nilda V. Jacobus, Laura A. McDermott
  • Susceptibility
    In Vitro Antibiotic Synergy in Extensively Drug-Resistant Acinetobacter baumannii: the Effect of Testing by Time-Kill, Checkerboard, and Etest Methods
    Thean Yen Tan, Tze Peng Lim, Winnie Hui Ling Lee, Suranthran Sasikala, Li Yang Hsu, Andrea Lay-Hoon Kwa

Letters

  • LETTERS TO THE EDITOR
    Extremely Drug-Resistant Citrobacter freundii Isolate Producing NDM-1 and Other Carbapenemases Identified in a Patient Returning from India
    Laurent Poirel, Alain Ros, Anne Carricajo, Philippe Berthelot, Bruno Pozzetto, Sandrine Bernabeu, Patrice Nordmann
  • LETTERS TO THE EDITOR
    Low Tigecycline Concentrations in the Cerebrospinal Fluid of a Neutropenic Patient with Inflamed Meninges
    Claudia Lengerke, Michael Haap, Frank Mayer, Lothar Kanz, Martina Kinzig, Ulrike Schumacher, Fritz Sörgel, Reimer Riessen
  • LETTERS TO THE EDITOR
    First Molecular Characterization of Fluoroquinolone Resistance in Aerococcus spp.
    Vincent Cattoir, Alfred Kobal, Patrick Legrand
  • LETTERS TO THE EDITOR
    qnrB19 Gene Bracketed by IS26 on a 40-Kilobase IncR Plasmid from an Escherichia coli Isolate from a Veal Calf
    Joost Hordijk, Angela B. Bosman, Alieda van Essen-Zandbergen, Kees Veldman, Cindy Dierikx, Jaap A. Wagenaar, Dik Mevius
  • LETTERS TO THE EDITOR
    High Mortality among Older Patients Treated with Pentavalent Antimonials for Visceral Leishmaniasis in East Africa and Rationale for Switch to Liposomal Amphotericin B
    François Chappuis, Emilie Alirol, Dagemlidet T. Worku, Yolanda Mueller, Koert Ritmeijer
  • LETTERS TO THE EDITOR
    Spread of the qnrVC Quinolone Resistance Determinant in Vibrio cholerae
    Érica Lourenço da Fonseca, Ana Carolina Paulo Vicente

Errata

  • Erratum
    Antileishmanial and Antitrypanosomal Activities of the 8-Aminoquinoline Tafenoquine
    Vanessa Yardley, Francisco Gamarro, Simon L. Croft
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Antimicrobial Agents and Chemotherapy: 55 (1)

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