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Mechanisms of Resistance

Differential Association of Plasmodium falciparum Na+/H+ Exchanger Polymorphism and Quinine Responses in Field- and Culture-Adapted Isolates of Plasmodium falciparum

Stéphane Pelleau, Lionel Bertaux, Sébastien Briolant, Michael T. Ferdig, Véronique Sinou, Bruno Pradines, Daniel Parzy, Ronan Jambou
Stéphane Pelleau
1Institut Pasteur de Dakar, BP 220 Dakar, Senegal
2Unité de Recherche en Physiologie et Pharmacocinétique Parasitaires, UMR-MD3, Relations Hôte-Parasites, Pharmacologie et Thérapeutique, Institut de Recherche Biomédicale des Armées, Antenne de Marseille, France
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Lionel Bertaux
2Unité de Recherche en Physiologie et Pharmacocinétique Parasitaires, UMR-MD3, Relations Hôte-Parasites, Pharmacologie et Thérapeutique, Institut de Recherche Biomédicale des Armées, Antenne de Marseille, France
3Centre National de Référence du Paludisme, Marseille, France
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Sébastien Briolant
4Unité de Recherche en Biologie et Epidémiologie Parasitaires, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR 6236, Institut de Recherche Biomédicale des Armées, Antenne de Marseille, France
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Michael T. Ferdig
5Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556
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Véronique Sinou
2Unité de Recherche en Physiologie et Pharmacocinétique Parasitaires, UMR-MD3, Relations Hôte-Parasites, Pharmacologie et Thérapeutique, Institut de Recherche Biomédicale des Armées, Antenne de Marseille, France
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Bruno Pradines
3Centre National de Référence du Paludisme, Marseille, France
4Unité de Recherche en Biologie et Epidémiologie Parasitaires, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR 6236, Institut de Recherche Biomédicale des Armées, Antenne de Marseille, France
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Daniel Parzy
2Unité de Recherche en Physiologie et Pharmacocinétique Parasitaires, UMR-MD3, Relations Hôte-Parasites, Pharmacologie et Thérapeutique, Institut de Recherche Biomédicale des Armées, Antenne de Marseille, France
3Centre National de Référence du Paludisme, Marseille, France
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Ronan Jambou
1Institut Pasteur de Dakar, BP 220 Dakar, Senegal
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  • For correspondence: rjambou@pasteur.fr
DOI: 10.1128/AAC.00477-11
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Article Information

DOI 
https://doi.org/10.1128/AAC.00477-11
PubMed 
21947391

Published By 
American Society for Microbiology Journals
History 
  • Received April 8, 2011
  • Returned for modification June 19, 2011
  • Accepted September 14, 2011
  • Published online November 11, 2011.

Copyright & Usage 
Copyright © 2011, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (September 26, 2011).
  • You are viewing the most recent version of this article.

Author Information

  1. Stéphane Pelleau1,2,
  2. Lionel Bertaux2,3,
  3. Sébastien Briolant4,
  4. Michael T. Ferdig5,
  5. Véronique Sinou2,
  6. Bruno Pradines3,4,
  7. Daniel Parzy2,3 and
  8. Ronan Jambou1*
  1. 1Institut Pasteur de Dakar, BP 220 Dakar, Senegal
  2. 2Unité de Recherche en Physiologie et Pharmacocinétique Parasitaires, UMR-MD3, Relations Hôte-Parasites, Pharmacologie et Thérapeutique, Institut de Recherche Biomédicale des Armées, Antenne de Marseille, France
  3. 3Centre National de Référence du Paludisme, Marseille, France
  4. 4Unité de Recherche en Biologie et Epidémiologie Parasitaires, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR 6236, Institut de Recherche Biomédicale des Armées, Antenne de Marseille, France
  5. 5Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556
  • ↵*Corresponding author. Mailing address: Institut Pasteur de Madagascar, BP 1274, Antananarivo 101, Madagascar. Phone: 261 20 22 590 14. Fax: 261 20 22 415 34. E-mail: rjambou{at}pasteur.fr.

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Differential Association of Plasmodium falciparum Na+/H+ Exchanger Polymorphism and Quinine Responses in Field- and Culture-Adapted Isolates of Plasmodium falciparum
Stéphane Pelleau, Lionel Bertaux, Sébastien Briolant, Michael T. Ferdig, Véronique Sinou, Bruno Pradines, Daniel Parzy, Ronan Jambou
Antimicrobial Agents and Chemotherapy Nov 2011, 55 (12) 5834-5841; DOI: 10.1128/AAC.00477-11

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Differential Association of Plasmodium falciparum Na+/H+ Exchanger Polymorphism and Quinine Responses in Field- and Culture-Adapted Isolates of Plasmodium falciparum
Stéphane Pelleau, Lionel Bertaux, Sébastien Briolant, Michael T. Ferdig, Véronique Sinou, Bruno Pradines, Daniel Parzy, Ronan Jambou
Antimicrobial Agents and Chemotherapy Nov 2011, 55 (12) 5834-5841; DOI: 10.1128/AAC.00477-11
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