Article Figures & Data
Tables
- Table 1.
Ribosomal mutations and erythromycin susceptibility in Campylobacter jejuni strains compared to C. jejuni DSM 4688 type straine
Strain(s) Erythromycin MIC (μg/ml)d 23S rRNA gene mutationa L4 mutation(s) L22 mutation(s) L22 insertion DSM 4688b 0.5 1 >128 wt A121V, I192M A74G, A109T, E111A, T114A, A130T, A132V, A141V, K144E 73-GAVLT-74 2–6 >128 A2059G A121V, I192M A74G, A109T, E111A, T114A, A130T, A132V, A141V, K144E 7 >128 A2059G wt A74G, A103V, A141V, K144E 8c >128 A2059G wt A74G, A103V, A141V 9, 10 >128 A2059G A121V, I192M, A196V V65I, A109S, A143V 11 >128 A2059G A121V, I192M Q24R, V65I, A143V 12 >128 A2059G A121V, I192M V65I, A103V 13 >128 A2059G A121V, I192M G86E 14 128 A2059G A121V, I192M A74G, A109T, E111A, T114A, A130T, A132V, A141V, K144E 15 128 A2059G wt V65I, A103V 16 64 wt T177S I65V, D72N 17, 18 8 wt A121V, I192M Q24R, V65I, A143V 19 8 wt A121V, I192M V65I, A109S, A143V 20, 22 4–8 wt A121V, I192M V65I, A103V 21 4 wt N95S, A121V, I192M Q24R, V65I, A143V 23 2 wr A129T, T201I wt 24, 25 1 wt A121V, I192M V65I, A109S, A143V 26, 30, 31 0.5–1 wt A121V, I192M, A196V V65I, A109S, A143V 27 1 wt wt V65I, A103V 28, 29 1 wt T177S V65I 32 0.5 wt V80I, A121V, I192M V65I, A103V 33 0.5 wt S132N, T177S V65I 34 0.5 wt A140T wt ↵a Position according to Escherichia coli numbering.
↵b Reference strain for the ribosomal proteins L4 and L22.
↵c Only two mutated copies of A2059G.
↵d From each MIC, a number of strains were selected for the efflux pump inhibitor (NMP and PAβN) testing, and no decrease in MIC was observed.
↵e Abbreviations: A, Ala; D, Asp; E, Glu; G, Gly; I, Ile; K, Lys; L, Leu; M, Met; N, Asn; Q, Gln; R, Arg; S, Ser; T, Thr; V, Val; wt, wild type, based on corresponding sequences of C. jejuni DSM 4688 type strain.
- Table 2.
Ribosomal mutations and erythromycin susceptibility in Campylobacter coli strains compared to C. coli DSM 4689 type straine
Strain(s) Erythromycin MIC (μg/ml) 23S rRNA gene mutationa L4 mutation(s) L22 mutation(s) L22 insertions DSM 4689b 0.5 wt 36 >128 A2059G S28P, T176S wt 41,c 37–40, 42–44 >128 A2059G S28P wt 45 >128 A2059G S28P, V121A, M192I wt 46, 47 >128 A2059G S28P, V121A, V176I, T177S, V184I, M192I A103V 48 >128 A2059G S28P G58S 49 >128 A2059G S28P, M192I T95I, A103V, T109A, A111E, A114T, V121A 119-TTTKA-120, 124-T-125 50 >128 A2059G S28P, M192I A103V, T109A, A111E, A114T, V121A 119-TTTKA-120, 124-T-125 51d 128 A2059G S28P, V121A, M192I A103V, T109A, A111E, A114T, V121A 119-TTTKA-120, 124-T-125 52 16 wt S28P wt 53 8 wt S28P, V121A, V176I, T177S, V184I, M192I A103V 54 8 wt S28P, M192I A103V, T109A, A111E, A114T, V121A 119-TTTKA-120, 124-T-125 ↵a Position according to Escherichia coli numbering.
↵b Reference strain for the ribosomal proteins L4 and L22.
↵c Only two mutated copies of A2059G.
↵d NMP caused 2-fold decrease in MIC.
↵e Abbreviations: A, Ala; E, Glu; G, Gly; I, Ile; K, Lys; M, Met; P, Pro; S, Ser; T, Thr; V, Val; wt, wild type, based on corresponding sequences of C. coli DSM 4689 type strain. One strain from each row was selected for the efflux pump inhibitor (NMP and PAβN) testing, and only one strain exhibited a 2-fold decrease in MIC.