Antimicrobial Agents and Chemotherapy: 55 (2)

February 2011; Volume 55,Issue 2

Minireviews

Minireview
Resistance of Herpes Simplex Viruses to Nucleoside Analogues: Mechanisms, Prevalence, and Management
Jocelyne Piret, Guy Boivin

Antiviral Agents

Antiviral Agents
Single-Dose Pharmacokinetics, Safety, and Tolerability of Albinterferon Alfa-2b in Subjects with End-Stage Renal Disease on Hemodialysis Compared to Those in Matched Healthy Volunteers
Denise B. Serra, Haiying Sun, Sylwia Karwowska, Jens Praestgaard, Atef Halabi, Daniel S. Stein
Antiviral Agents
Alkylated Porphyrins Have Broad Antiviral Activity against Hepadnaviruses, Flaviviruses, Filoviruses, and Arenaviruses
Haitao Guo, Xiaoben Pan, Richeng Mao, Xianchao Zhang, Lijuan Wang, Xuanyong Lu, Jinhong Chang, Ju-Tao Guo, Shendra Passic, Fred C. Krebs, Brian Wigdahl, Travis K. Warren, Cary J. Retterer, Sina Bavari, Xiaodong Xu, Andrea Cuconati, Timothy M. Block
Antiviral Agents
Characterization of the E138K Resistance Mutation in HIV-1 Reverse Transcriptase Conferring Susceptibility to Etravirine in B and Non-B HIV-1 Subtypes
Eugene L. Asahchop, Maureen Oliveira, Mark A. Wainberg, Bluma G. Brenner, Daniela Moisi, Thomas d'Aquin Toni, Cecile L. Tremblay
Antiviral Agents
Identification of High-Affinity PB1-Derived Peptides with Enhanced Affinity to the PA Protein of Influenza A Virus Polymerase
Kerstin Wunderlich, Mindaugas Juozapaitis, Charlene Ranadheera, Ulrich Kessler, Arnold Martin, Jessica Eisel, Ulrike Beutling, Ronald Frank, Martin Schwemmle
Antiviral Agents
In Vivo Patterns of Resistance to the HIV Attachment Inhibitor BMS-488043
Nannan Zhou, Beata Nowicka-Sans, Sharon Zhang, Li Fan, Jie Fang, Hua Fang, Yi-Fei Gong, Betsy Eggers, David R. Langley, Tao Wang, John Kadow, Dennis Grasela, George J. Hanna, Louis Alexander, Richard Colonno, Mark Krystal, Pin-Fang Lin
Antiviral Agents
T-705 (Favipiravir) Inhibition of Arenavirus Replication in Cell Culture
Michelle Mendenhall, Andrew Russell, Terry Juelich, Emily L. Messina, Donald F. Smee, Alexander N. Freiberg, Michael R. Holbrook, Yousuke Furuta, Juan-Carlos de la Torre, Jack H. Nunberg, Brian B. Gowen
Antiviral Agents
In Vitro Antiretroviral Properties of S/GSK1349572, a Next-Generation HIV Integrase Inhibitor
Masanori Kobayashi, Tomokazu Yoshinaga, Takahiro Seki, Chiaki Wakasa-Morimoto, Kevin W. Brown, Robert Ferris, Scott A. Foster, Richard J. Hazen, Shigeru Miki, Akemi Suyama-Kagitani, Shinobu Kawauchi-Miki, Teruhiko Taishi, Takashi Kawasuji, Brian A. Johns, Mark R. Underwood, Edward P. Garvey, Akihiko Sato, Tamio Fujiwara
Antiviral Agents
Complementarity-Determining Region 3 Size Spectratypes of T Cell Receptor β Chains in CD8⁺ T Cells following Antiviral Treatment of Chronic Hepatitis B
Shi-Wu Ma, Yong-Yin Li, Guang-Wen Zhang, Xuan Huang, Jian Sun, Chris Li, William G. H. Abbott, Jin-Lin Hou
Antiviral Agents
Determinants of Individual Variation in Intracellular Accumulation of Anti-HIV Nucleoside Analog Metabolites
Elijah Paintsil, Ginger E. Dutschman, Rong Hu, Susan P. Grill, Chuan-Jen Wang, Wing Lam, Fang-Yong Li, Musie Ghebremichael, Veronika Northrup, Yung-Chi Cheng
Antiviral Agents
Sustained Viral Response in a Hepatitis C Virus-Infected Chimpanzee via a Combination of Direct-Acting Antiviral Agents
David B. Olsen, Mary-Ellen Davies, Larry Handt, Kenneth Koeplinger, Nanyan Rena Zhang, Steven W. Ludmerer, Donald Graham, Nigel Liverton, Malcolm MacCoss, Daria Hazuda, Steven S. Carroll

Experimental Therapeutics

Experimental Therapeutics
Vancomycin Bonded to Bone Grafts Prevents Bacterial Colonization
Constantinos Ketonis, Stephanie Barr, Christopher S. Adams, Irving M. Shapiro, Javad Parvizi, Noreen J. Hickok
Experimental Therapeutics
Tigecycline Exhibits Inhibitory Activity against Clostridium difficile in the Colon of Mice and Does Not Promote Growth or Toxin Production
Robin L. P. Jump, Yuejin Li, Michael J. Pultz, Georgios Kypriotakis, Curtis J. Donskey
Experimental Therapeutics
In Vitro Activity and In Vivo Efficacy of Posaconazole in Treatment of Murine Infections by Different Isolates of the Aspergillus terreus Complex
Valentina Salas, F. Javier Pastor, M. M. Rodríguez, Enrique Calvo, Emilio Mayayo, Josep Guarro
Experimental Therapeutics
In Vitro and In Vivo Efficacies of Mefloquine-Based Treatment against Alveolar Echinococcosis
Tatiana Küster, Britta Stadelmann, Corina Hermann, Sabrina Scholl, Jennifer Keiser, Andrew Hemphill
Experimental Therapeutics
A Novel Chimeric Lysin Shows Superiority to Mupirocin for Skin Decolonization of Methicillin-Resistant and -Sensitive Staphylococcus aureus Strains
Mina Pastagia, Chad Euler, Peter Chahales, Judilyn Fuentes-Duculan, James G. Krueger, Vincent A. Fischetti
Experimental Therapeutics
Pharmacodynamic Modeling of In Vitro Activity of Marbofloxacin against Escherichia coli Strains
M. Andraud, C. Chauvin, P. Sanders, M. Laurentie
Experimental Therapeutics
Use of an In Vitro Pharmacodynamic Model To Derive a Moxifloxacin Regimen That Optimizes Kill of Yersinia pestis and Prevents Emergence of Resistance
A. Louie, H. S. Heine, B. VanScoy, A. Eichas, K. Files, S. Fikes, D. L. Brown, W. Liu, M. Kinzig-Schippers, F. Sörgel, G. L. Drusano
Experimental Therapeutics
Determination of the Duration of Antibacterial Efficacy following Administration of Gamithromycin Using a Bovine Mannheimia haemolytica Challenge Model
A. B. Forbes, C. Ramage, J. Sales, D. Baggott, W. Donachie
Experimental Therapeutics
Novel Biocatalytic Polymer-Based Antimicrobial Coatings as Potential Ureteral Biomaterial: Preparation and In Vitro Performance Evaluation
Rachna N. Dave, Hiren M. Joshi, Vayalam P. Venugopalan
Experimental Therapeutics
Quaternized Chitosan Inhibits icaA Transcription and Biofilm Formation by Staphylococcus on a Titanium Surface
Zhao-Xiang Peng, Bing Tu, Yang Shen, Lin Du, Ling Wang, Sheng-Rong Guo, Ting-Ting Tang
Experimental Therapeutics
Efficacy of Fosfomycin in Experimental Osteomyelitis Due to Methicillin-Resistant Staphylococcus aureus
W. Poeppl, S. Tobudic, T. Lingscheid, R. Plasenzotti, N. Kozakowski, A. Georgopoulos, H. Burgmann

Mechanisms of Resistance

Mechanisms of Resistance
Clinical Characteristics of Bloodstream Infections Due to Ampicillin-Sulbactam-Resistant, Non-Extended- Spectrum-β-Lactamase-Producing Escherichia coli and the Role of TEM-1 Hyperproduction
Rebecca I. Waltner-Toews, David L. Paterson, Zubair A. Qureshi, Hanna E. Sidjabat, Jennifer M. Adams-Haduch, Kathleen A. Shutt, Mark Jones, Guo-Bao Tian, Anthony W. Pasculle, Yohei Doi
Mechanisms of Resistance
mexEF-oprN Multidrug Efflux Operon of Pseudomonas aeruginosa: Regulation by the MexT Activator in Response to Nitrosative Stress and Chloramphenicol
Hossam Fetar, Christie Gilmour, Rachael Klinoski, Denis M. Daigle, Charles R. Dean, Keith Poole
Mechanisms of Resistance
Peptide Antibiotic Sensing and Detoxification Modules of Bacillus subtilis
Anna Staroń, Dora Elisabeth Finkeisen, Thorsten Mascher
Mechanisms of Resistance
Outbreak of Colistin-Resistant, Carbapenem-Resistant Klebsiella pneumoniae in Metropolitan Detroit, Michigan
Dror Marchaim, Teena Chopra, Jason M. Pogue, Federico Perez, Andrea M. Hujer, Susan Rudin, Andrea Endimiani, Shiri Navon-Venezia, Jatinder Hothi, Jessica Slim, Christopher Blunden, Maryann Shango, Paul R. Lephart, Hossein Salimnia, Deborah Reid, Judy Moshos, Wasif Hafeez, Suchitha Bheemreddy, Ting-Yi Chen, Sorabh Dhar, Robert A. Bonomo, Keith S. Kaye
Mechanisms of Resistance
Molecular Characterization of Fluoroquinolone Resistance in Mycobacterium tuberculosis: Functional Analysis of gyrA Mutation at Position 74
Ricky W. T. Lau, Pak-Leung Ho, Richard Y. T. Kao, Wing-Wai Yew, Terrence C. K. Lau, Vincent C. C. Cheng, Kwok-Yung Yuen, Stephen K. W. Tsui, Xinchun Chen, Wing-Cheong Yam
Mechanisms of Resistance
Limited Ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 Polymorphisms To Predict Quinine In Vitro Sensitivity or Clinical Effectiveness in Uganda
Frederick N. Baliraine, Samuel L. Nsobya, Jane Achan, James K. Tibenderana, Ambrose O. Talisuna, Bryan Greenhouse, Philip J. Rosenthal
Mechanisms of Resistance
Whole-Genome Analysis of Salmonella enterica Serovar Typhimurium T000240 Reveals the Acquisition of a Genomic Island Involved in Multidrug Resistance via IS1 Derivatives on the Chromosome
Hidemasa Izumiya, Tsuyoshi Sekizuka, Hideo Nakaya, Masumi Taguchi, Akio Oguchi, Natsuko Ichikawa, Rika Nishiko, Shuji Yamazaki, Nobuyuki Fujita, Haruo Watanabe, Makoto Ohnishi, Makoto Kuroda
Mechanisms of Resistance
Different Genetic Elements Carrying the tet(W) Gene in Two Human Clinical Isolates of Streptococcus suis
Claudio Palmieri, Maria Stella Princivalli, Andrea Brenciani, Pietro E. Varaldo, Bruna Facinelli
Mechanisms of Resistance
Molecular Analysis of Antimicrobial Resistance Mechanisms in Neisseria gonorrhoeae Isolates from Ontario, Canada
Vanessa G. Allen, David J. Farrell, Anuradha Rebbapragada, Jingyuan Tan, Nathalie Tijet, Stephen J. Perusini, Lynn Towns, Stephen Lo, Donald E. Low, Roberto G. Melano
Mechanisms of Resistance
Mutation Analysis of the Mycobacterium leprae folP1 Gene and Dapsone Resistance
Noboru Nakata, Masanori Kai, Masahiko Makino
Mechanisms of Resistance
rmtD2, a New Allele of a 16S rRNA Methylase Gene, Has Been Present in Enterobacteriaceae Isolates from Argentina for More than a Decade
Nathalie Tijet, Patricia Andres, Catherine Chung, Celeste Lucero, Donald E. Low, Marcelo Galas, Alejandra Corso, Alejandro Petroni, Roberto G. Melano
and WHONET-Argentina Group
Mechanisms of Resistance
ISAba825, a Functional Insertion Sequence Modulating Genomic Plasticity and bla _OXA-58 Expression in Acinetobacter baumannii
Pablo Ravasi, Adriana S. Limansky, Ramiro E. Rodriguez, Alejandro M. Viale, María A. Mussi
Mechanisms of Resistance
Expression of Multidrug Efflux Pump Genes acrAB-tolC, mdfA, and norE in Escherichia coli Clinical Isolates as a Function of Fluoroquinolone and Multidrug Resistance
Michelle C. Swick, Sonia K. Morgan-Linnell, Kimberly M. Carlson, Lynn Zechiedrich
Mechanisms of Resistance
Detection of NDM-1-Producing Klebsiella pneumoniae in Kenya
Laurent Poirel, Gunturu Revathi, Sandrine Bernabeu, Patrice Nordmann
Mechanisms of Resistance
An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates of Candida albicans
Samantha J. Hoot, Adam R. Smith, Ryan P. Brown, Theodore C. White
Mechanisms of Resistance
Use of Inverse PCR for Analysis of Class 1 Integrons Carrying an Unusual 3′ Conserved Segment Structure
Mei-Feng Lee, Chien-Fang Peng, Hui-Jine Hsu, Han-Siong Toh

Pharmacology

Pharmacology
Impact of P-Glycoprotein Inhibition and Lipopolysaccharide Administration on Blood-Brain Barrier Transport of Colistin in Mice
Liang Jin, Jian Li, Roger L. Nation, Joseph A. Nicolazzo
Pharmacology
In Silico Children and the Glass Mouse Model: Clinical Trial Simulations To Identify and Individualize Optimal Isoniazid Doses in Children with Tuberculosis
Prakash M. Jeena, William R. Bishai, Jotam G. Pasipanodya, Tawanda Gumbo
Pharmacology
Therapeutic Drug Monitoring of Piperacillin-Tazobactam Using Spent Dialysate Effluent in Patients Receiving Continuous Venovenous Hemodialysis
Michael J. Connor, Charbel Salem, Seth R. Bauer, Christina L. Hofmann, Joseph Groszek, Robert Butler, Susan J. Rehm, William H. Fissell
Pharmacology
Combinatorial Phenotypic Signatures Distinguish Persistent from Resolving Methicillin-Resistant Staphylococcus aureus Bacteremia Isolates
Kati Seidl, Arnold S. Bayer, Vance G. Fowler, James A. McKinnell, Wessam Abdel Hady, George Sakoulas, Michael R. Yeaman, Yan Q. Xiong
Pharmacology
Phase 2, Randomized, Double-Blind, Dose-Ranging Study Evaluating the Safety, Tolerability, Population Pharmacokinetics, and Efficacy of Oral Torezolid Phosphate in Patients with Complicated Skin and Skin Structure Infections
P. Prokocimer, P. Bien, J. Surber, P. Mehra, C. DeAnda, J. B. Bulitta, G. R. Corey
Pharmacology
Pharmacokinetic Interaction Study of Ritonavir-Boosted Saquinavir in Combination with Rifabutin in Healthy Subjects
Xiaoping Zhang, Scott Fettner, Elke Zwanziger, Lucy Rowell, Miklos Salgo
Pharmacology
Antiviral Activity, Pharmacokinetics, and Safety of BMS-488043, a Novel Oral Small-Molecule HIV-1 Attachment Inhibitor, in HIV-1-Infected Subjects
George J. Hanna, Jacob Lalezari, James A. Hellinger, David A. Wohl, Richard Nettles, Anna Persson, Mark Krystal, Pinfang Lin, Richard Colonno, Dennis M. Grasela
Pharmacology
Comparative Effects of Carbapenems on Bacterial Load and Host Immune Response in a Klebsiella pneumoniae Murine Pneumonia Model
Jamese J. Hilliard, John L. Melton, LeRoy Hall, Darren Abbanat, Jeffrey Fernandez, Christine K. Ward, Rachel A. Bunting, A. Barron, A. Simon Lynch, Robert K. Flamm
Pharmacology
Pharmacodynamics of Telavancin Studied in an In Vitro Pharmacokinetic Model of Infection
Alasdair P. MacGowan, Alan R. Noel, Sharon Tomaselli, Heather C. Elliott, Karen E. Bowker
Pharmacology
Raltegravir Is a Substrate for SLC22A6: a Putative Mechanism for the Interaction between Raltegravir and Tenofovir
Darren M. Moss, Wai San Kwan, Neill J. Liptrott, Darren L. Smith, Marco Siccardi, Saye H. Khoo, David J. Back, Andrew Owen
Pharmacology
Human Tissue Distribution of Voriconazole
Stefan Weiler, David Fiegl, Róisín MacFarland, Eva Stienecke, Rosa Bellmann-Weiler, Stefan Dunzendorfer, Michael Joannidis, Romuald Bellmann

Mechanisms of Action

Mechanisms of Action: Physiological Effects
Carotenoid-Related Alteration of Cell Membrane Fluidity Impacts Staphylococcus aureus Susceptibility to Host Defense Peptides
Nagendra N. Mishra, George Y. Liu, Michael R. Yeaman, Cynthia C. Nast, Richard A. Proctor, James McKinnell, Arnold S. Bayer
Mechanisms of Action: Physiological Effects
Artemisone Uptake in Plasmodium falciparum-Infected Erythrocytes
Sophie Pooley, Farrah A. Fatih, Sanjeev Krishna, Michael Gerisch, Richard K. Haynes, Ho-Ning Wong, Henry M. Staines
Mechanisms of Action: Physiological Effects
Mechanisms Mediating Bactericidal Properties and Conditions That Enhance the Potency of a Broad-Spectrum Oligo-Acyl-Lysyl
Hadar Sarig, Yair Goldfeder, Shahar Rotem, Amram Mor
Mechanisms of Action: Physiological Effects
The Antibiotic Monensin Causes Cell Cycle Disruption of Toxoplasma gondii Mediated through the DNA Repair Enzyme TgMSH-1
Mark D. Lavine, Gustavo Arrizabalaga
Mechanisms of Action: Physiological Effects
Interaction of W-Substituted Analogs of Cyclo-RRRWFW with Bacterial Lipopolysaccharides: the Role of the Aromatic Cluster in Antimicrobial Activity
Mojtaba Bagheri, Sandro Keller, Margitta Dathe
Mechanisms of Action: Physiological Effects
Antibacterial Action of Polyphosphate on Porphyromonas gingivalis
Ji-Hoi Moon, Jae-Hong Park, Jin-Yong Lee
Mechanisms of Action: Physiological Effects
The In Vitro Contribution of Autolysins to Bacterial Killing Elicited by Amoxicillin Increases with Inoculum Size in Enterococcus faecalis
Vincent Dubée, Françoise Chau, Michel Arthur, Louis Garry, Samira Benadda, Stéphane Mesnage, Agnès Lefort, Bruno Fantin

Clinical Therapeutics

Clinical Therapeutics
Recent Exposure to Caspofungin or Fluconazole Influences the Epidemiology of Candidemia: a Prospective Multicenter Study Involving 2,441 Patients
Olivier Lortholary, Marie Desnos-Ollivier, Karine Sitbon, Arnaud Fontanet, Stéphane Bretagne, Françoise Dromer
and and the French Mycosis Study Group
Clinical Therapeutics
Biomarker-Assisted Dose Selection for Safety and Efficacy in Early Development of PNU-100480 for Tuberculosis
Robert S. Wallis, Wesley Jakubiec, Vikas Kumar, Gabriella Bedarida, Annette Silvia, Darcy Paige, Tong Zhu, Mark Mitton-Fry, Lynn Ladutko, Sheldon Campbell, Paul F. Miller

Epidemiology and Surveillance

Epidemiology and Surveillance
Candida Bloodstream Infections: Comparison of Species Distributions and Antifungal Resistance Patterns in Community-Onset and Nosocomial Isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009
Michael A. Pfaller, Gary J. Moet, Shawn A. Messer, Ronald N. Jones, Mariana Castanheira
Epidemiology and Surveillance
In Vitro Antimicrobial Susceptibility of Bacterial Enteropathogens Isolated from International Travelers to Mexico, Guatemala, and India from 2006 to 2008
Jeannette Ouyang-Latimer, Syed Jafri, Audrey VanTassel, Zhi-Dong Jiang, Kaur Gurleen, Savio Rodriguez, Ranjan K. Nandy, Thandavaryan Ramamurthy, Santanu Chatterjee, Robin McKenzie, Robert Steffen, Herbert L. DuPont
Epidemiology and Surveillance
Fluoroquinolone Resistance among Mycobacterium tuberculosis Strains from Karachi, Pakistan: Data from Community-Based Field Clinics
Yasraba Rafiq, Kauser Jabeen, Rumina Hasan, Sana Jafri, Rabia Laiq, Faisal Malik, Rafique Mangi, Abid Channa, Zahra Hasan

Susceptibility

Susceptibility
A Rapid, High-Throughput Viability Assay for Blastocystis spp. Reveals Metronidazole Resistance and Extensive Subtype-Dependent Variations in Drug Susceptibilities
Haris Mirza, Joshua D. W. Teo, Jacqui Upcroft, Kevin S. W. Tan
Susceptibility
Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin against Staphylococcus aureus
Sandrine Lemaire, Paul M. Tulkens, Françoise Van Bambeke
Susceptibility
In Silico Screening, Structure-Activity Relationship, and Biologic Evaluation of Selective Pteridine Reductase Inhibitors Targeting Visceral Leishmaniasis
Jaspreet Kaur, Pranav Kumar, Sargam Tyagi, Richa Pathak, Sanjay Batra, Prashant Singh, Neeloo Singh
Open Access

Susceptibility
In Vitro Antimicrobial Activity of Wall Teichoic Acid Biosynthesis Inhibitors against Staphylococcus aureus Isolates
Takashi Suzuki, Jonathan G. Swoboda, Jennifer Campbell, Suzanne Walker, Michael S. Gilmore
Susceptibility
Assessment of Clarithromycin Susceptibility in Strains Belonging to the Mycobacterium abscessus Group by erm(41) and rrl Sequencing
Sylvaine Bastian, Nicolas Veziris, Anne-Laure Roux, Florence Brossier, Jean-Louis Gaillard, Vincent Jarlier, Emmanuelle Cambau

Analytical Procedures

Analytical Procedures
High-Throughput Giardia lamblia Viability Assay Using Bioluminescent ATP Content Measurements
Catherine Z. Chen, Liudmila Kulakova, Noel Southall, Juan J. Marugan, Andrey Galkin, Christopher P. Austin, Osnat Herzberg, Wei Zheng
Analytical Procedures
Molecular Assessment of Plasmodium falciparum Resistance to Antimalarial Drugs in Papua New Guinea Using an Extended Ligase Detection Reaction Fluorescent Microsphere Assay
Rina P. M. Wong, Harin Karunajeewa, Ivo Mueller, Peter Siba, Peter A. Zimmerman, Timothy M. E. Davis
Analytical Procedures
Development and Validation of a High-Performance Liquid Chromatography Method for Determination of Cefquinome Concentrations in Sheep Plasma and Its Application to Pharmacokinetic Studies
Kamil Uney, Feray Altan, Muammer Elmas

Chemistry; Biosynthesis

Chemistry; Biosynthesis
Diversity of the Early Step of the Futalosine Pathway
Chisato Arakawa, Masahiro Kuratsu, Kazuo Furihata, Tomoshige Hiratsuka, Nobuya Itoh, Haruo Seto, Tohru Dairi

Author's Correction

AUTHOR'S CORRECTION
Origin and Molecular Evolution of the Determinant of Methicillin Resistance in Staphylococci
Sae Tsubakishita, Kyoko Kuwahara-Arai, Takashi Sasaki, Keiichi Hiramatsu

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Table of Contents

Minireviews

Antiviral Agents

Experimental Therapeutics

Mechanisms of Resistance

Pharmacology

Mechanisms of Action

Clinical Therapeutics

Epidemiology and Surveillance

Susceptibility

Analytical Procedures

Chemistry; Biosynthesis

Author's Correction

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