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Mechanisms of Action: Physiological Effects

Auranofin Protects against Anthrax Lethal Toxin-Induced Activation of the Nlrp1b Inflammasome

Zachary L. Newman, Nicole Sirianni, Christina Mawhinney, Margaret S. Lee, Stephen H. Leppla, Mahtab Moayeri, Lisa M. Johansen
Zachary L. Newman
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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Nicole Sirianni
Zalicus Inc., Cambridge, Massachusetts
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Christina Mawhinney
Zalicus Inc., Cambridge, Massachusetts
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Margaret S. Lee
Zalicus Inc., Cambridge, Massachusetts
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Stephen H. Leppla
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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Mahtab Moayeri
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
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Lisa M. Johansen
Zalicus Inc., Cambridge, Massachusetts
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  • For correspondence: ljohansen@zalicus.com
DOI: 10.1128/AAC.00772-10
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Article Information

DOI 
https://doi.org/10.1128/AAC.00772-10
PubMed 
21149629

Published By 
American Society for Microbiology Journals
History 
  • Received June 7, 2010
  • Returned for modification September 26, 2010
  • Accepted November 29, 2010
  • Published online February 24, 2011.

Copyright & Usage 
Copyright © 2011, American Society for Microbiology

Article Versions

  • Accepted Manuscript version (December 13, 2010).
  • You are viewing the most recent version of this article.

Author Information

  1. Zachary L. Newman1†,
  2. Nicole Sirianni2†‡,
  3. Christina Mawhinney2§,
  4. Margaret S. Lee2,
  5. Stephen H. Leppla1,
  6. Mahtab Moayeri1 and
  7. Lisa M. Johansen2*
  1. 1National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland
  2. 2Zalicus Inc., Cambridge, Massachusetts
  • ↵† Z. L. Newman and N. Sirianni contributed equally to this work.

  • ↵‡ Current address: School of Management, Simons College, 300 Fenway, Boston, MA 02115.

  • ↵§ Current address: National Emerging Infectious Diseases Laboratories Institute, Boston University Medical Campus, 715 Albany Street, Boston, MA 02118.

  • ↵* Corresponding author. Mailing address: Zalicus Inc., 245 First Street, Cambridge, MA 02142. Phone: (617) 301-7117. Fax: (617) 301-7010. E-mail: ljohansen{at}zalicus.com
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Auranofin Protects against Anthrax Lethal Toxin-Induced Activation of the Nlrp1b Inflammasome
Zachary L. Newman, Nicole Sirianni, Christina Mawhinney, Margaret S. Lee, Stephen H. Leppla, Mahtab Moayeri, Lisa M. Johansen
Antimicrobial Agents and Chemotherapy Feb 2011, 55 (3) 1028-1035; DOI: 10.1128/AAC.00772-10

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Auranofin Protects against Anthrax Lethal Toxin-Induced Activation of the Nlrp1b Inflammasome
Zachary L. Newman, Nicole Sirianni, Christina Mawhinney, Margaret S. Lee, Stephen H. Leppla, Mahtab Moayeri, Lisa M. Johansen
Antimicrobial Agents and Chemotherapy Feb 2011, 55 (3) 1028-1035; DOI: 10.1128/AAC.00772-10
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