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Table of Contents

June 1, 2011; Volume 55,Issue 6

Pharmacology

  • Pharmacology
    Prospective, Open-Label Investigation of the Pharmacokinetics of Daptomycin during Cardiopulmonary Bypass Surgery
    Megan H. Nguyen, Samantha J. Eells, Jennifer Tan, Corinne T. Sheth, Bassam Omari, Margarita Flores, Jeffrey Wang, Loren G. Miller
  • Pharmacology
    Pharmacokinetic Profiles of Ceftazidime after Intravenous Administration in Patients Undergoing Automated Peritoneal Dialysis
    Kiwon Kim, Young-Hwan Hwang, Han Ro, Yun Kyu Oh, Min-gul Kim, Kyung-Sang Yu, Kwang-Hee Shin, In-Jin Jang, Sang Goo Shin, Curie Ahn, Kook-Hwan Oh
  • Pharmacology
    Optimization of Aminoglycoside Therapy
    G. L. Drusano, Arnold Louie
  • Pharmacology
    Sesame Oil Prevents Acute Kidney Injury Induced by the Synergistic Action of Aminoglycoside and Iodinated Contrast in Rats
    Dur-Zong Hsu, Ya-Hui Li, Pei-Yi Chu, Srinivasan Periasamy, Ming-Yie Liu
  • Pharmacology
    Steady-State Plasma Pharmacokinetics of Oral Voriconazole in Obese Adults
    Manjunath P. Pai, Thomas P. Lodise
  • Pharmacology
    Pharmacokinetics and Safety of MP-376 (Levofloxacin Inhalation Solution) in Cystic Fibrosis Subjects
    David E. Geller, Patrick A. Flume, David C. Griffith, Elizabeth Morgan, Dan White, Jeffery S. Loutit, Michael N. Dudley
  • Pharmacology
    Vancomycin Dosing in Critically Ill Patients: Robust Methods for Improved Continuous-Infusion Regimens
    Jason A. Roberts, Fabio Silvio Taccone, Andrew A. Udy, Jean-Louis Vincent, Frédérique Jacobs, Jeffrey Lipman
  • Pharmacology
    Efficacy of Simulated Cefditoren versus Amoxicillin-Clavulanate Free Concentrations in Countering Intrastrain ftsI Gene Diffusion in Haemophilus influenzae
    Natalia González, Lorenzo Aguilar, David Sevillano, Maria-Jose Giménez, Luis Alou, Fabio Cafini, Martha Torrico, Ana-Maria López, Pilar Coronel, Jose Prieto
  • Pharmacology
    Pharmacokinetics and Safety of FV-100, a Novel Oral Anti-Herpes Zoster Nucleoside Analogue, Administered in Single and Multiple Doses to Healthy Young Adult and Elderly Adult Volunteers
    Helen S. Pentikis, Mark Matson, George Atiee, Brian Boehlecke, Jeff T. Hutchins, Joseph M. Patti, Geoffrey W. Henson, Amy Morris
  • Pharmacology
    Comparable Population Pharmacokinetics and Pharmacodynamic Breakpoints of Cefpirome in Cystic Fibrosis Patients and Healthy Volunteers
    J. B. Bulitta, M. Kinzig, C. B. Landersdorfer, U. Holzgrabe, U. Stephan, F. Sörgel
  • Pharmacology
    Very High Concentrations of Active Intracellular Phosphorylated Emtricitabine in Neonates (ANRS 12109 Trial, Step 2)
    Déborah Hirt, Alain Pruvost, Didier K. Ekouévi, Saïk Urien, Elise Arrivé, Mamourou Kone, Eric Nerrienet, Mandisa Nyati, Glenda Gray, Leang Sim Kruy, Stéphane Blanche, François Dabis, Jean-Marc Tréluyer
  • Pharmacology
    Plasma and Intracellular Tenofovir Pharmacokinetics in the Neonate (ANRS 12109 Trial, Step 2)
    Déborah Hirt, Didier K. Ekouévi, Alain Pruvost, Saïk Urien, Elise Arrivé, Stéphane Blanche, Divine Avit, Clarisse Amani-Bosse, Mandisa Nyati, Shini Legote, Meng L. Ek, Leakhena Say, James McIntyre, François Dabis, Jean-Marc Tréluyer
  • Pharmacology
    Evaluation of the Mean Corpuscular Volume of Peripheral Blood Mononuclear Cells of HIV Patients by a Coulter Counter To Determine Intracellular Drug Concentrations
    Marco Simiele, Antonio D'Avolio, Lorena Baietto, Marco Siccardi, Mauro Sciandra, Silvia Agati, Jessica Cusato, Stefano Bonora, Giovanni Di Perri
  • Pharmacology
    Changes in Antibiotic Distribution Due to Pancreatitis
    Kent J. Fanning, Thomas A. Robertson, Johannes B. Prins, Michael S. Roberts

Mechanisms of Resistance

  • Mechanisms of Resistance
    Loss of Heterozygosity of FCY2 Leading to the Development of Flucytosine Resistance in Candida tropicalis
    Yen-Ning Chen, Hsiu-Jung Lo, Chia-Chen Wu, Hui-Ching Ko, Te-Pin Chang, Yun-Liang Yang
  • Mechanisms of Resistance
    Mutations in gidB Confer Low-Level Streptomycin Resistance in Mycobacterium tuberculosis
    Sharon Y. Wong, Jong Seok Lee, Hyun Kyung Kwak, Laura E. Via, Helena I. M. Boshoff, Clifton E. Barry
  • Mechanisms of Resistance
    OXA-163, an OXA-48-Related Class D β-Lactamase with Extended Activity Toward Expanded-Spectrum Cephalosporins
    Laurent Poirel, Mariana Castanheira, Amélie Carrër, Carla Parada Rodriguez, Ronald N. Jones, Jorgelina Smayevsky, Patrice Nordmann
  • Mechanisms of Resistance
    Off-Target Gene Regulation Mediated by Transcriptional Repressors of Antimicrobial Efflux Pump Genes in Neisseria gonorrhoeae
    Paul J. T. Johnson, Virginia A. Stringer, William M. Shafer
  • Mechanisms of Resistance
    Artesunate Tolerance in Transgenic Plasmodium falciparum Parasites Overexpressing a Tryptophan-Rich Protein
    Guillaume Deplaine, Catherine Lavazec, Emmanuel Bischoff, Onguma Natalang, Sylvie Perrot, Micheline Guillotte-Blisnick, Jean-Yves Coppée, Bruno Pradines, Odile Mercereau-Puijalon, Peter H. David
  • Mechanisms of Resistance
    PME-1, an Extended-Spectrum β-Lactamase Identified in Pseudomonas aeruginosa
    Guo-Bao Tian, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Hong-Ning Wang, Yohei Doi
  • Mechanisms of Resistance
    Evolution and Spread of a Multidrug-Resistant Proteus mirabilis Clone with Chromosomal AmpC-Type Cephalosporinases in Europe
    M. M. D'Andrea, E. Literacka, A. Zioga, T. Giani, A. Baraniak, J. Fiett, E. Sadowy, P. T. Tassios, G. M. Rossolini, M. Gniadkowski, V. Miriagou
  • Mechanisms of Resistance
    Microtiter Plate-Based Assay for Inhibitors of Penicillin-Binding Protein 2a from Methicillin-Resistant Staphylococcus aureus
    Sudheer Bobba, V. K. Chaithanya Ponnaluri, Mridul Mukherji, William G. Gutheil
  • Mechanisms of Resistance
    In Vitro Selection of ramR and soxR Mutants Overexpressing Efflux Systems by Fluoroquinolones as Well as Cefoxitin in Klebsiella pneumoniae
    Suzanne Bialek-Davenet, Estelle Marcon, Véronique Leflon-Guibout, Jean-Philippe Lavigne, Frédéric Bert, Richard Moreau, Marie-Hélène Nicolas-Chanoine
  • Mechanisms of Resistance
    Multiple Origins of Plasmodium falciparum Dihydropteroate Synthetase Mutant Alleles Associated with Sulfadoxine Resistance in India
    Vanshika Lumb, Manoj K. Das, Neeru Singh, Vas Dev, Wajihullah Khan, Yagya D. Sharma
  • Mechanisms of Resistance
    Mycobacterium tuberculosis embB Codon 306 Mutations Confer Moderately Increased Resistance to Ethambutol In Vitro and In Vivo
    Claudia Plinke, Kerstin Walter, Sahar Aly, Stefan Ehlers, Stefan Niemann
  • Mechanisms of Resistance
    Mutation in the sdeS Gene Promotes Expression of the sdeAB Efflux Pump Genes and Multidrug Resistance in Serratia marcescens
    Hideaki Maseda, Yumiko Hashida, Akihiro Shirai, Takeshi Omasa, Taiji Nakae
  • Mechanisms of Resistance
    First Report of Klebsiella oxytoca Strain Coproducing KPC-2 and IMP-8 Carbapenemases
    Bin Li, Jing-Yong Sun, Qing-Zhong Liu, Li-Zhong Han, Xin-Hong Huang, Yu-Xing Ni
  • Mechanisms of Resistance
    Emergence of Escherichia coli Sequence Type ST131 Carrying both the blaGES-5 and blaCTX-M-15 Genes
    Juwon Kim, Seong Geun Hong, Il Kwon Bae, Ji Roung Kang, Seok Hoon Jeong, Wookeun Lee, Kyungwon Lee
  • Mechanisms of Resistance
    A Novel Gene Cassette, aacA43, in a Plasmid-Borne Class 1 Integron
    Sally R. Partridge, Lee C. Thomas, Andrew N. Ginn, Agnieszka M. Wiklendt, Pierre Kyme, Jonathan R. Iredell
  • Mechanisms of Resistance
    Novel Mutations in a Patient Isolate of Streptococcus agalactiae with Reduced Penicillin Susceptibility Emerging after Long-Term Oral Suppressive Therapy
    Jean Longtin, Christie Vermeiren, Dea Shahinas, Gurdip Singh Tamber, Allison McGeer, Donald E. Low, Kevin Katz, Dylan R. Pillai
  • Mechanisms of Resistance
    Characteristics of NDM-1-Producing Escherichia coli Isolates That Belong to the Successful and Virulent Clone ST131
    Gisele Peirano, Paul C. Schreckenberger, Johann D. D. Pitout
  • Mechanisms of Resistance
    Inactivation of the Indigenous Methyltransferase RlmN in Staphylococcus aureus Increases Linezolid Resistance
    Jacqueline M. LaMarre, Benjamin P. Howden, Alexander S. Mankin
  • Mechanisms of Resistance
    Insertion Sequence ISAba11 Is Involved in Colistin Resistance and Loss of Lipopolysaccharide in Acinetobacter baumannii
    Jennifer H. Moffatt, Marina Harper, Ben Adler, Roger L. Nation, Jian Li, John D. Boyce
  • Mechanisms of Resistance
    Emergence of NDM-1-Producing Enterobacteriaceae in Belgium
    Pierre Bogaerts, Warda Bouchahrouf, Roberta Rezende de Castro, Ariane Deplano, Catherine Berhin, Denis Piérard, Olivier Denis, Youri Glupczynski

Antiviral Agents

  • Antiviral Agents
    Inhibitory Effect of a Triterpenoid Compound, with or without Alpha Interferon, on Hepatitis C Virus Infection
    Takako Watanabe, Naoya Sakamoto, Mina Nakagawa, Sei Kakinuma, Yasuhiro Itsui, Yuki Nishimura-Sakurai, Mayumi Ueyama, Yusuke Funaoka, Akiko Kitazume, Sayuri Nitta, Kei Kiyohashi, Miyako Murakawa, Seishin Azuma, Kiichiro Tsuchiya, Shinya Oooka, Mamoru Watanabe
  • Antiviral Agents
    The Kinetic Effects on Thymidine Kinase 2 by Enzyme-Bound dTTP May Explain the Mitochondrial Side Effects of Antiviral Thymidine Analogs
    Liya Wang, Ren Sun, Staffan Eriksson
  • Antiviral Agents
    Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine
    Angela M. Lam, Christine Espiritu, Eisuke Murakami, Veronique Zennou, Shalini Bansal, Holly M. Micolochick Steuer, Congrong Niu, Meg Keilman, Haiying Bao, Nigel Bourne, Ronald L. Veselenak, P. Ganapati Reddy, Wonsuk Chang, Jinfa Du, Dhanapalan Nagarathnam, Michael J. Sofia, Michael J. Otto, Phillip A. Furman
  • Antiviral Agents
    Mechanism of Resistance to GS-9148 Conferred by the Q151L Mutation in HIV-1 Reverse Transcriptase
    Brian J. Scarth, Kirsten L. White, James M. Chen, Eric B. Lansdon, S. Swaminathan, Michael D. Miller, Matthias Götte
  • Antiviral Agents
    The HIV Protease Inhibitor Nelfinavir Inhibits Kaposi's Sarcoma-Associated Herpesvirus Replication In Vitro
    Soren Gantt, Jacquelyn Carlsson, Minako Ikoma, Eliora Gachelet, Matthew Gray, Adam P. Geballe, Lawrence Corey, Corey Casper, Michael Lagunoff, Jeffrey Vieira
  • Open Access
    Antiviral Agents
    Pharmacokinetics and Pharmacodynamics of TBR-652, a Novel CCR5 Antagonist, in HIV-1-Infected, Antiretroviral Treatment-Experienced, CCR5 Antagonist-Naïve Patients
    Jean-Francois Marier, MyMy Trinh, Leng Hong Pheng, Sandra M. Palleja, David E. Martin
  • Open Access
    Antiviral Agents
    Sequential Population Pharmacokinetic Modeling of Lopinavir and Ritonavir in Healthy Volunteers and Assessment of Different Dosing Strategies
    Laura Dickinson, Marta Boffito, David Back, Laura Else, Nils von Hentig, Geraint Davies, Saye Khoo, Anton Pozniak, Graeme Moyle, Leon Aarons
  • Open Access
    Antiviral Agents
    Intravenous Peramivir for Treatment of Influenza A and B Virus Infection in High-Risk Patients
    Shigeru Kohno, Hiroshi Kida, Masashi Mizuguchi, Nobuo Hirotsu, Tadashi Ishida, Junichi Kadota, Jingoro Shimada, the S-021812 Clinical Study Group
  • Antiviral Agents
    Concordance between Two Phenotypic Assays and Ultradeep Pyrosequencing for Determining HIV-1 Tropism
    Adrien Saliou, Pierre Delobel, Martine Dubois, Florence Nicot, Stéphanie Raymond, Vincent Calvez, Bernard Masquelier, Jacques Izopet, the ANRS AC11 Resistance Study Group
  • Antiviral Agents
    Connection Domain Mutations in HIV-1 Reverse Transcriptase Do Not Impact Etravirine Susceptibility and Virologic Responses to Etravirine-Containing Regimens
    Soumi Gupta, Johan Vingerhoets, Signe Fransen, Lotke Tambuyzer, Hilde Azijn, Arne Frantzell, Roger Paredes, Eoin Coakley, Steven Nijs, Bonaventura Clotet, Christos J. Petropoulos, Jonathan Schapiro, Wei Huang, Gaston Picchio
  • Antiviral Agents
    Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors
    Eric B. Lansdon, Qi Liu, Stephanie A. Leavitt, Mini Balakrishnan, Jason K. Perry, Candra Lancaster-Moyer, Nilima Kutty, Xiaohong Liu, Neil H. Squires, William J. Watkins, Thorsten A. Kirschberg
  • Antiviral Agents
    Combinatorial Effect of Two Framework Mutations (E119V and I222L) in the Neuraminidase Active Site of H3N2 Influenza Virus on Resistance to Oseltamivir
    Mathilde Richard, Olivier Ferraris, Alexandra Erny, Mendy Barthélémy, Aurélien Traversier, Murielle Sabatier, Alan Hay, Yi Pu Lin, Rupert J. Russell, Bruno Lina
  • Antiviral Agents
    Raltegravir Concentrations in the Genital Tract of HIV-1-Infected Women Treated with a Raltegravir-Containing Regimen (DIVA 01 Study)
    Cyril Clavel, Gilles Peytavin, Roland Tubiana, Cathia Soulié, Catherine Crenn-Hebert, Isabelle Heard, François Bissuel, Houria Ichou, Claudia Ferreira, Christine Katlama, Anne-Geneviève Marcelin, Laurent Mandelbrot

Experimental Therapeutics

  • Experimental Therapeutics
    Effect of Antibiotic Treatment on Establishment and Elimination of Intestinal Colonization by KPC-Producing Klebsiella pneumoniae in Mice
    Federico Perez, Michael J. Pultz, Andrea Endimiani, Robert A. Bonomo, Curtis J. Donskey
  • Experimental Therapeutics
    Activity of Carbapenems Combined with Clavulanate against Murine Tuberculosis
    Nicolas Veziris, Chantal Truffot, Jean-Luc Mainardi, Vincent Jarlier
  • Experimental Therapeutics
    Aminoindoles, a Novel Scaffold with Potent Activity against Plasmodium falciparum
    Robert H. Barker, Sameer Urgaonkar, Ralph Mazitschek, Cassandra Celatka, Renato Skerlj, Joseph F. Cortese, Erin Tyndall, Hanlan Liu, Mandy Cromwell, Amar Bir Sidhu, Jose E. Guerrero-Bravo, Keila N. Crespo-Llado, Adelfa E. Serrano, Jing-wen Lin, Chris J. Janse, Shahid M. Khan, Manoj Duraisingh, Bradley I. Coleman, Inigo Angulo-Barturen, María Belén Jiménez-Díaz, Noemí Magán, Vanesa Gomez, Santiago Ferrer, María Santos Martínez, Sergio Wittlin, Petros Papastogiannidis, Thomas O'Shea, Jeffrey D. Klinger, Mark Bree, Edward Lee, Mikaela Levine, Roger C. Wiegand, Benito Munoz, Dyann F. Wirth, Jon Clardy, Ian Bathurst, Edmund Sybertz
  • Experimental Therapeutics
    Comparative Efficacies of Candidate Antibiotics against Yersinia pestis in an In Vitro Pharmacodynamic Model
    Arnold Louie, Brian VanScoy, Weiguo Liu, Robert Kulawy, David Brown, Henry S. Heine, George L. Drusano
  • Experimental Therapeutics
    Chemical Characterization and Biological Properties of NVC-422, a Novel, Stable N-Chlorotaurine Analog
    Lu Wang, Barbara Belisle, Mansour Bassiri, Ping Xu, Dmitri Debabov, Chris Celeri, Nichole Alvarez, Martin C. Robson, Wyatt G. Payne, Ramin Najafi, Behzad Khosrovi
  • Experimental Therapeutics
    Saturability of Granulocyte Kill of Pseudomonas aeruginosa in a Murine Model of Pneumonia
    G. L. Drusano, B. VanScoy, W. Liu, S. Fikes, D. Brown, A. Louie
  • Experimental Therapeutics
    In Vitro and In Vivo Intracellular Killing Effects of Tigecycline against Clinical Nontyphoid Salmonella Isolates Using Ceftriaxone as a Comparator
    Hung-Jen Tang, Wen-Chien Ko, Chi-Chung Chen, Po-Lin Chen, Han Siong Toh, Tzu Chieh Weng, Wen-Liang Yu, Shyh-Ren Chiang, Yin-Ching Chuang
  • Experimental Therapeutics
    Induction of Antimalaria Immunity by Pyrimethamine Prophylaxis during Exposure to Sporozoites Is Curtailed by Parasite Resistance
    Johannes Friesen, Steffen Borrmann, Kai Matuschewski
  • Experimental Therapeutics
    Improved Oxacillin Treatment Outcomes in Experimental Skin and Lung Infection by a Methicillin-Resistant Staphylococcus aureus Isolate with a vraSR Operon Deletion
    Dae Sun Jo, Christopher P. Montgomery, Shaohui Yin, Susan Boyle-Vavra, Robert S. Daum
  • Experimental Therapeutics
    Double-Carbapenem Therapy for Carbapenemase-Producing Klebsiella pneumoniae
    Catharine C. Bulik, David P. Nicolau
  • Experimental Therapeutics
    Antimalarial Effects of Human Immunodeficiency Virus Protease Inhibitors in Rhesus Macaques
    Youjia Li, Li Qin, Nanzheng Peng, Guangjie Liu, Siting Zhao, Zhengxiang He, Xiaoping Chen
  • Experimental Therapeutics
    Antimicrobial Peptoids Are Effective against Pseudomonas aeruginosa Biofilms
    Rinki Kapoor, Mayken W. Wadman, Michelle T. Dohm, Ann M. Czyzewski, Alfred M. Spormann, Annelise E. Barron

Mechanisms of Action: Physiological Effects

  • Mechanisms of Action: Physiological Effects
    Proteomic Signature of Fatty Acid Biosynthesis Inhibition Available for In Vivo Mechanism-of-Action Studies
    Michaela Wenzel, Malay Patra, Dirk Albrecht, David Y.-K. Chen, K. C. Nicolaou, Nils Metzler-Nolte, Julia E. Bandow
  • Mechanisms of Action: Physiological Effects
    Dynamics of the Action of Biocides in Pseudomonas aeruginosa Biofilms
    A. Bridier, F. Dubois-Brissonnet, G. Greub, V. Thomas, R. Briandet
  • Mechanisms of Action: Physiological Effects
    Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo
    Gilles Brackman, Paul Cos, Louis Maes, Hans J. Nelis, Tom Coenye
  • Mechanisms of Action: Physiological Effects
    Novel Inhibitors of the Pseudomonas aeruginosa Virulence Factor LasB: a Potential Therapeutic Approach for the Attenuation of Virulence Mechanisms in Pseudomonal Infection
    George R. A. Cathcart, Derek Quinn, Brett Greer, Pat Harriott, John F. Lynas, Brendan F. Gilmore, Brian Walker
  • Mechanisms of Action: Physiological Effects
    A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans in Multispecies Biofilms
    Chang Liu, Roberta J. Worthington, Christian Melander, Hui Wu
  • Mechanisms of Action: Physiological Effects
    Decrease in Penicillin Susceptibility Due to Heat Shock Protein ClpL in Streptococcus pneumoniae
    Thao Dang-Hien Tran, Hyog-Young Kwon, Eun-Hye Kim, Ki-Woo Kim, David E. Briles, Suhkneung Pyo, Dong-Kwon Rhee
  • Mechanisms of Action: Physiological Effects
    Mechanism of Action and Limited Cross-Resistance of New Lipopeptide MX-2401
    E. Rubinchik, T. Schneider, M. Elliott, W. R. P. Scott, J. Pan, C. Anklin, H. Yang, D. Dugourd, A. Müller, K. Gries, S. K. Straus, H. G. Sahl, R. E. W. Hancock
  • Mechanisms of Action: Physiological Effects
    Use of a Selective Inhibitor To Define the Chemotherapeutic Potential of the Plasmodial Hexose Transporter in Different Stages of the Parasite's Life Cycle
    Ksenija Slavic, Michael J. Delves, Miguel Prudêncio, Arthur M. Talman, Ursula Straschil, Elvira T. Derbyshire, Zhengyao Xu, Robert E. Sinden, Maria M. Mota, Christophe Morin, Rita Tewari, Sanjeev Krishna, Henry M. Staines
  • Mechanisms of Action: Physiological Effects
    In Vitro and In Vivo Profiles of ACH-702, an Isothiazoloquinolone, against Bacterial Pathogens
    Michael J. Pucci, Steven D. Podos, Jane A. Thanassi, Melissa J. Leggio, Barton J. Bradbury, Milind Deshpande
  • Mechanisms of Action: Physiological Effects
    Structure-Activity Studies and Therapeutic Potential of Host Defense Peptides of Human Thrombin
    Gopinath Kasetty, Praveen Papareddy, Martina Kalle, Victoria Rydengård, Matthias Mörgelin, Barbara Albiger, Martin Malmsten, Artur Schmidtchen
  • Mechanisms of Action: Physiological Effects
    Cholesterol Enhances Helicobacter pylori Resistance to Antibiotics and LL-37
    David J. McGee, Alika E. George, Elizabeth A. Trainor, Katherine E. Horton, Ellen Hildebrandt, Traci L. Testerman
  • Mechanisms of Action: Physiological Effects
    Synergistic Effect of 14-Alpha-Lipoyl Andrographolide and Various Antibiotics on the Formation of Biofilms and Production of Exopolysaccharide and Pyocyanin by Pseudomonas aeruginosa
    Xiangping Zeng, Xiangyang Liu, Jiang Bian, Gang Pei, Huanqin Dai, Steven W. Polyak, Fuhang Song, Li Ma, Yuqiang Wang, Lixin Zhang

Epidemiology and Surveillance

  • Epidemiology and Surveillance
    Trends in Antifungal Drug Susceptibility of Cryptococcus neoformans Isolates Obtained through Population-Based Surveillance in South Africa in 2002-2003 and 2007-2008
    Nelesh P. Govender, Jaymati Patel, Marelize van Wyk, Tom M. Chiller, Shawn R. Lockhart, for the Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA)
  • Epidemiology and Surveillance
    Antimicrobial Susceptibilities and Serotypes of Streptococcus pneumoniae Isolates from Elderly Patients with Pneumonia and Acute Exacerbation of Chronic Obstructive Pulmonary Disease
    Emilio Pérez-Trallero, José M. Marimón, Julián Larruskain, Marta Alonso, María Ercibengoa
  • Epidemiology and Surveillance
    Detection of the KPC Gene in Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii during a PCR-Based Nosocomial Surveillance Study in Puerto Rico
    Iraida E. Robledo, Edna E. Aquino, Guillermo J. Vázquez
  • Epidemiology and Surveillance
    Distribution of Antiseptic Resistance Genes qacA, qacB, and smr in Methicillin-Resistant Staphylococcus aureus Isolated in Toronto, Canada, from 2005 to 2009
    Jean Longtin, Christine Seah, Krystal Siebert, Allison McGeer, Andrew Simor, Yves Longtin, Donald E. Low, Roberto G. Melano
  • Epidemiology and Surveillance
    Antimicrobial Resistance in Fecal Escherichia coli Isolates from Healthy Urban Children of Two Age Groups in Relation to Their Antibiotic Therapy
    Ivan Literak, Radim Petro, Monika Dolejska, Erika Gruberova, Hana Dobiasova, Jan Petr, Alois Cizek
  • Epidemiology and Surveillance
    Novel Types of Staphylococcal Cassette Chromosome mec Elements Identified in Clonal Complex 398 Methicillin-Resistant Staphylococcus aureus Strains
    Shanshuang Li, Robert Leo Skov, Xiao Han, Anders Rhod Larsen, Jesper Larsen, Marit Sørum, Mireille Wulf, Andreas Voss, Keiichi Hiramatsu, Teruyo Ito
  • Epidemiology and Surveillance
    Consumption Patterns and In Vitro Resistance of Streptococcus pneumoniae to Fluoroquinolones
    Steven Simoens, Jan Verhaegen, Pascal van Bleyenbergh, Willy E. Peetermans, Marc Decramer

Clinical Therapeutics

  • Clinical Therapeutics
    Effect of Nutritional Status on Response to Treatment with Artemisinin-Based Combination Therapy in Young Ugandan Children with Malaria
    Wendy J. Verret, Emmanuel Arinaitwe, Humphrey Wanzira, Victor Bigira, Abel Kakuru, Moses Kamya, Jordan W. Tappero, Taylor Sandison, Grant Dorsey
  • Clinical Therapeutics
    Enhancement of Amoxicillin Resistance after Unsuccessful Helicobacter pylori Eradication
    Toshihiro Nishizawa, Hidekazu Suzuki, Hitoshi Tsugawa, Hiroe Muraoka, Juntaro Matsuzaki, Kenro Hirata, Fumiaki Ikeda, Masahiko Takahashi, Toshifumi Hibi

Susceptibility

  • Susceptibility
    Paradoxical Effect of Caspofungin against Candida Bloodstream Isolates Is Mediated by Multiple Pathways but Eliminated in Human Serum
    Ryan K. Shields, M. Hong Nguyen, Chen Du, Ellen Press, Shaoji Cheng, Cornelius J. Clancy
  • Susceptibility
    In Vitro Activity of Ceftaroline against Gram-Positive and Gram-Negative Pathogens Isolated from Patients in Canadian Hospitals in 2009
    James A. Karlowsky, Heather J. Adam, Melanie R. DeCorby, Philippe R. S. Lagacé-Wiens, Daryl J. Hoban, George G. Zhanel
  • Susceptibility
    Wild-Type MIC Distributions and Epidemiological Cutoff Values for Caspofungin and Aspergillus spp. for the CLSI Broth Microdilution Method (M38-A2 Document)
    A. Espinel-Ingroff, A. Fothergill, J. Fuller, E. Johnson, T. Pelaez, J. Turnidge
  • Susceptibility
    Antimony-Resistant Clinical Isolates of Leishmania donovani Are Susceptible to Paromomycin and Sitamaquine
    Arpita Kulshrestha, Ruchi Singh, Dhiraj Kumar, Narender Singh Negi, Poonam Salotra
  • Susceptibility
    Molecular Drug Susceptibility Testing and Genotyping of Mycobacterium leprae Strains from South America
    Pushpendra Singh, Philippe Busso, Alberto Paniz-Mondolfi, Nacarid Aranzazu, Marc Monot, Nadine Honore, Andrea de Faria Fernandes Belone, Marcos Virmond, Maria Esther Villarreal-Olaya, Carlos Rivas, Stewart T. Cole
  • Susceptibility
    In Vitro Activity of Ceftazidime Combined with NXL104 versus Pseudomonas aeruginosa Isolates Obtained from Patients in Canadian Hospitals (CANWARD 2009 Study)
    A. Walkty, M. DeCorby, P. R. S. Lagacé-Wiens, J. A. Karlowsky, D. J. Hoban, G. G. Zhanel
  • Susceptibility
    Susceptibility of 186 Nocardia sp. Isolates to 20 Antimicrobial Agents
    Julián Larruskain, Pedro Idigoras, José M. Marimón, Emilio Pérez-Trallero
  • Susceptibility
    Polyphasic Identification and Susceptibility to Seven Antifungals of 102 Aspergillus Isolates Recovered from Immunocompromised Hosts in Greece
    Michael Arabatzis, Manousos Kambouris, Miltiades Kyprianou, Aikaterini Chrysaki, Maria Foustoukou, Maria Kanellopoulou, Lydia Kondyli, Georgia Kouppari, Chrysa Koutsia-Karouzou, Evangelia Lebessi, Anastasia Pangalis, Efthimia Petinaki, Ageliki Stathi, Eleftheria Trikka-Graphakos, Erriketi Vartzioti, Aliki Vogiatzi, Timoleon-Achilleas Vyzantiadis, Loukia Zerva, Aristea Velegraki
  • Susceptibility
    In Vitro Activities of Anidulafungin and Other Antifungal Agents against Biofilms Formed by Clinical Isolates of Different Candida and Aspergillus Species
    Barbara Fiori, Brunella Posteraro, Riccardo Torelli, Mario Tumbarello, David S. Perlin, Giovanni Fadda, Maurizio Sanguinetti
  • Susceptibility
    Gentian Violet Exhibits Activity against Biofilms Formed by Oral Candida Isolates Obtained from HIV-Infected Patients
    Rana S. Traboulsi, Pranab K. Mukherjee, Jyotsna Chandra, Robert A. Salata, Richard Jurevic, Mahmoud A. Ghannoum
  • Susceptibility
    Efficacy of Antimicrobial Peptoids against Mycobacterium tuberculosis
    Rinki Kapoor, Patrick R. Eimerman, Jonathan W. Hardy, Jeffrey D. Cirillo, Christopher H. Contag, Annelise E. Barron

Letter to the Editor

  • Letter to the Editor
    Isolation of Pseudomonas aeruginosa Coproducing Metallo-β-Lactamase SPM-1 and 16S rRNA Methylase RmtD1 in an Urban River
    Lívia C. Fontes, Patrícia R. Neves, Silvane Oliveira, Ketrin C. Silva, Elayse M. Hachich, Maria I. Z. Sato, Nilton Lincopan

Erratum

  • Erratum
    Cross-Resistance to Lincosamides, Streptogramins A, and Pleuromutilins Due to the lsa(C) Gene in Streptococcus agalactiae UCN70
    Brigitte Malbruny, Anja M. Werno, David R. Murdoch, Roland Leclercq, Vincent Cattoir
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Antimicrobial Agents and Chemotherapy: 55 (6)

In This Issue

volume 55, issue 6
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  • Pharmacology
  • Mechanisms of Resistance
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  • Experimental Therapeutics
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  • Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity Against SARS-CoV-2
  • Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling
  • Fact versus Fiction: a Review of the Evidence behind Alcohol and Antibiotic Interactions
  • Povidone Iodine: Properties, Mechanisms of Action, and Role in Infection Control and Staphylococcus aureus Decolonization
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