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- Table 1.
Susceptibilities and molecular characteristics of NDM-1-producing E. coli CH01 and MH01
Parameter Value or characteristic for E. coli strain: CH01 MH01 MICa (μg/ml) of: AMC >16/8 >16/8 TZP >64/4 >64/4 FOX >16 >16 CRO >32 >32 CAZ >16 >16 ATM 8 >16 MER >8 >8 IPM >8 >8 AMK >32 >32 GEN >8 >8 TOB >8 >8 CIP >2 >2 SXT >1/19 >1/19 NIT ≤32 >64 β-Lactamase(s) NDM-1 NDM-1, CTX-M-15 Plasmid-mediated quinolone resistance determinant aac(6′)-Ib-cr aac(6′)-Ib MLST result ST131 ST101 Plasmid sizes (kb) 120, 300 75, 165, 300, 400 Replicon typing results IncA/C, IncFIA IncA/C, IncFII Phylogenetic group B2 B1 Virulence characteristicsb Adhesins F10 papA Pos Neg papACEFG Neg Neg sfa foc Neg Neg focG Neg Neg iha Pos Neg fimH Pos Pos tsh Neg Neg hra Neg Pos afa dra Neg Neg Toxins hlyD Neg Neg sat Pos Neg pic Neg Neg vat Neg Neg astA Neg Neg cnf1 Neg Neg Siderophores iroN Neg Neg fyuA Pos Pos ireA Neg Neg iutA Pos Neg Capsule kpsM II Pos Neg K1 Neg Neg K2 Pos Neg K5 Neg Neg Miscellaneous usp Pos Pos traT Pos Neg ompT Pos Neg iss Neg Neg fliCH7 Neg Neg malX Pos Neg ↵a MICs were determined using the Microscan NEG MIC 30 panel. MIC values for the respective drugs in a drug combination are separated by a slash.
↵b The presence (Pos) or absence (Neg) of each virulence characteristic is indicated. F10 papA, P fimbria subunit variant; papACEFG, genes of P fimbria operon; sfa foc, S or F1C fimbriae; focG, F1C fimbria adhesin; iha, adhesion siderophore; fimH, type 1 fimbriae; tsh, temperature-sensitive hemagglutinin; hra, heat-resistant agglutinin; afa dra, Dr-binding adhesins; hlyD, α-hemolysin; sat, secreted autotransporter toxin; pic, serine protease; vat, vacuolating toxin; astA, enteroaggregative E. coli toxin; cnf1, cytotoxic necrotizing factor; iroN, salmochelin (siderophore) receptor; fyuA, yersiniabactin (siderophore) receptor; ireA, siderophore receptor; iutA, aerobactin (siderophore) receptor; kpsM II, group 2 capsule; K1, K2, and K5, group 2 capsule variants; usp, uropathogen-specific protein; traT, serum resistance-associated protein; ompT, outer membrane protease T; iss, increased serum survival; fliCH7, flagellin variant; malX, pathogenicity island marker.
