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Efficacy of Antimicrobial Peptoids against Mycobacterium tuberculosis

Rinki Kapoor, Patrick R. Eimerman, Jonathan W. Hardy, Jeffrey D. Cirillo, Christopher H. Contag, Annelise E. Barron
Rinki Kapoor
1Biophysics Program, Stanford University, Stanford, California 94305
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Patrick R. Eimerman
2and Departments of Microbiology and Immunology, Stanford University, Stanford, California 94305
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Jonathan W. Hardy
2and Departments of Microbiology and Immunology, Stanford University, Stanford, California 94305
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Jeffrey D. Cirillo
3Department of Microbial & Molecular Pathogenesis, Texas A&M Health Science Center, College Station, Texas 77843-1114
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Christopher H. Contag
2and Departments of Microbiology and Immunology, Stanford University, Stanford, California 94305
4Pediatrics, Stanford University, Stanford, California 94305
5Radiology, Stanford University, Stanford, California 94305
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Annelise E. Barron
1Biophysics Program, Stanford University, Stanford, California 94305
6Bioengineering, Stanford University, Stanford, California 94305
7Chemical Engineering, Stanford University, Stanford, California 94305
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  • For correspondence: aebarron@stanford.edu
DOI: 10.1128/AAC.01667-10
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ABSTRACT

Tuberculosis is a leading cause of death worldwide. Resistance of Mycobacterium to antibiotics can make treatments less effective in some cases. We tested selected oligopeptoids—previously reported as mimics of natural host defense peptides—for activity against Mycobacterium tuberculosis and assessed their cytotoxicity. A tetrameric, alkylated, cationic peptoid (1-C134mer) was most potent against M. tuberculosis and least cytotoxic, whereas an unalkylated analogue, peptoid 14mer, was inactive. Peptoid 1-C134mer thus merits further study as a potential antituberculosis drug.

  • Copyright © 2011, American Society for Microbiology
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Efficacy of Antimicrobial Peptoids against Mycobacterium tuberculosis
Rinki Kapoor, Patrick R. Eimerman, Jonathan W. Hardy, Jeffrey D. Cirillo, Christopher H. Contag, Annelise E. Barron
Antimicrobial Agents and Chemotherapy May 2011, 55 (6) 3058-3062; DOI: 10.1128/AAC.01667-10

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Efficacy of Antimicrobial Peptoids against Mycobacterium tuberculosis
Rinki Kapoor, Patrick R. Eimerman, Jonathan W. Hardy, Jeffrey D. Cirillo, Christopher H. Contag, Annelise E. Barron
Antimicrobial Agents and Chemotherapy May 2011, 55 (6) 3058-3062; DOI: 10.1128/AAC.01667-10
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