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Clinical Therapeutics

Stability of Colistimethate Sodium in Aqueous Solution

A. M. Healan, W. Gray, E. J. Fuchs, J. M. Griffiss, R. A. Salata, J. Blumer
A. M. Healan
aDivision of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, Ohio, USA
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W. Gray
bDepartment of Pediatrics, University of Toledo College of Medicine, Toledo, Ohio, USA
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E. J. Fuchs
cDrug Development Unit, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
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J. M. Griffiss
dClinicalRM, Hinkley, Ohio, USA
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R. A. Salata
aDivision of Infectious Diseases and HIV Medicine, Case Western Reserve University, Cleveland, Ohio, USA
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J. Blumer
bDepartment of Pediatrics, University of Toledo College of Medicine, Toledo, Ohio, USA
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DOI: 10.1128/AAC.01079-12
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ABSTRACT

Colistimethate sodium, increasingly used to treat multidrug-resistant Gram-negative infections, spontaneously hydrolyzes to form colistin A (polymyxin E1) and B (polymyxin E2/B) when mixed with water. High levels of these active breakdown products at the time of administration have been associated with nephrotoxicity and even death. In this study, reconstituted colistimethate sodium was shown to be stable (<1.0% colistin A/B formation) for up to 24 h when stored at 21, 0, −20, and −70°C.

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Stability of Colistimethate Sodium in Aqueous Solution
A. M. Healan, W. Gray, E. J. Fuchs, J. M. Griffiss, R. A. Salata, J. Blumer
Antimicrobial Agents and Chemotherapy Nov 2012, 56 (12) 6432-6433; DOI: 10.1128/AAC.01079-12

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Stability of Colistimethate Sodium in Aqueous Solution
A. M. Healan, W. Gray, E. J. Fuchs, J. M. Griffiss, R. A. Salata, J. Blumer
Antimicrobial Agents and Chemotherapy Nov 2012, 56 (12) 6432-6433; DOI: 10.1128/AAC.01079-12
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