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Clinical Therapeutics

Stability of Extemporaneously Prepared 0.5-Percent Caspofungin Eye Drops: a Potential Cost-Savings Exercise

Chin Fen Neoh, Jovan Jacob, Lok Leung, Jian Li, Angela Stathopoulos, Kay Stewart, David C. M. Kong
Chin Fen Neoh
aCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
bFacility for Anti-infective Drug Development and Innovation, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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Jovan Jacob
bFacility for Anti-infective Drug Development and Innovation, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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Lok Leung
cDepartment of Pharmacy, Royal Victorian Eye and Ear Hospital (RVEEH), East Melbourne, Victoria, Australia
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Jian Li
bFacility for Anti-infective Drug Development and Innovation, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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Angela Stathopoulos
cDepartment of Pharmacy, Royal Victorian Eye and Ear Hospital (RVEEH), East Melbourne, Victoria, Australia
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Kay Stewart
aCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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David C. M. Kong
aCentre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
bFacility for Anti-infective Drug Development and Innovation, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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DOI: 10.1128/AAC.00060-12
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ABSTRACT

While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5%) eye drops were aseptically prepared, and the concentrations were measured using a validated high-performance liquid chromatography (HPLC) analysis. The preparations remained stable for 28 days under refrigerated condition but not at 25.0°C. Our study supports the cost-saving use of caspofungin eye drops in the clinical setting.

  • Copyright © 2012, American Society for Microbiology. All Rights Reserved.
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Stability of Extemporaneously Prepared 0.5-Percent Caspofungin Eye Drops: a Potential Cost-Savings Exercise
Chin Fen Neoh, Jovan Jacob, Lok Leung, Jian Li, Angela Stathopoulos, Kay Stewart, David C. M. Kong
Antimicrobial Agents and Chemotherapy May 2012, 56 (6) 3435-3437; DOI: 10.1128/AAC.00060-12

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Stability of Extemporaneously Prepared 0.5-Percent Caspofungin Eye Drops: a Potential Cost-Savings Exercise
Chin Fen Neoh, Jovan Jacob, Lok Leung, Jian Li, Angela Stathopoulos, Kay Stewart, David C. M. Kong
Antimicrobial Agents and Chemotherapy May 2012, 56 (6) 3435-3437; DOI: 10.1128/AAC.00060-12
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