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Antiviral Agents

Fluoxetine Is a Potent Inhibitor of Coxsackievirus Replication

Jun Zuo, Kevin K. Quinn, Steve Kye, Paige Cooper, Robert Damoiseaux, Paul Krogstad
Jun Zuo
aDepartment of Pediatrics, University of California, Los Angeles, California, USA
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Kevin K. Quinn
aDepartment of Pediatrics, University of California, Los Angeles, California, USA
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Steve Kye
aDepartment of Pediatrics, University of California, Los Angeles, California, USA
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Paige Cooper
aDepartment of Pediatrics, University of California, Los Angeles, California, USA
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Robert Damoiseaux
bCalifornia Nanosystems Institute, University of California, Los Angeles, California, USA
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Paul Krogstad
aDepartment of Pediatrics, University of California, Los Angeles, California, USA
cDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
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DOI: 10.1128/AAC.00983-12
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ABSTRACT

No antiviral drugs currently exist for the treatment of enterovirus infections, which are often severe and potentially life threatening. Molecular screening of small molecule libraries identified fluoxetine, a selective serotonin reuptake inhibitor, as a potent inhibitor of coxsackievirus replication. Fluoxetine did not interfere with either viral entry or translation of the viral genome. Instead, fluoxetine and its metabolite norfluoxetine markedly reduced the synthesis of viral RNA and protein. In view of its favorable pharmacokinetics and safety profile, fluoxetine warrants additional study as a potential antiviral agent for enterovirus infections.

  • Copyright © 2012, American Society for Microbiology. All Rights Reserved.
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Fluoxetine Is a Potent Inhibitor of Coxsackievirus Replication
Jun Zuo, Kevin K. Quinn, Steve Kye, Paige Cooper, Robert Damoiseaux, Paul Krogstad
Antimicrobial Agents and Chemotherapy Aug 2012, 56 (9) 4838-4844; DOI: 10.1128/AAC.00983-12

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Fluoxetine Is a Potent Inhibitor of Coxsackievirus Replication
Jun Zuo, Kevin K. Quinn, Steve Kye, Paige Cooper, Robert Damoiseaux, Paul Krogstad
Antimicrobial Agents and Chemotherapy Aug 2012, 56 (9) 4838-4844; DOI: 10.1128/AAC.00983-12
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