DOI: 10.1128/AAC.01686-12
Article Figures & Data
Tables
- Table 1
Numbers of K. pneumoniae isolates that produce different carbapenemasesa
Carbapenemase Country of isolation KPC types (n = 47) KPC-2 (n = 23) Greece (n = 14), USA (n = 7), Israel (n = 1), Puerto Rico (n = 1) KPC-3 (n = 18) USA (n = 9), Israel (n = 8), Columbia (n = 1) KPC-11 (n = 6) Greece (n = 6) NDM-1 (n = 26) India (n = 26) OXA-48-like (n = 13) OXA-48 (n = 6) Turkey (n = 3), Argentina (n = 1), USA (n = 2) OXA-163 (n = 2) Argentina (n = 2) OXA-181 (n = 5) India (n = 5) VIM types (n = 19) VIM-1 (n = 16) Greece (n = 13), Spain (n = 2), Italy (n = 1) VIM-5 (n = 1) Greece (n = 1) VIM-27 (n = 1) Turkey (n = 1) VIM-33 (n = 1) Greece (n = 1) IMP-26 (n = 5) Australia (n = 2), Philippines (n = 3) ↵a n, no. of isolates.
- Table 2
Sequence types of Klebsiella pneumoniae that produce carbapenemases
Sequence type Carbapenemase ESBL or AmpC Country of isolation ST11 (n = 11) Pulsotype 11A (n = 3) OXA-48 CTX-M-15 Turkey, Argentinia Pulsotype 11B (n = 3) NDM-1 CTX-M-15, DHA-1 India Pulsotype 11C (n = 2) OXA-163 Argentina Pulsotype 11D (n = 3) NDM-1 CTX-M-15 India ST147 (n = 23) Pulsotype 147A (n = 9) NDM-1 CTX-M-15, CMY-2 India Pulsotype 147B (n = 2) OXA-181 CTX-M-15 India Pulsotype 147C (n = 12) VIM-1, −27, 33 SHV-12, -31, DHA-1 Greece, Italy ST258 (n = 38) Pulsotype 258A (n = 7) KPC-3 SHV-12, CTX-M-14 USA, Israel Pulsotype 258B (n = 6) KPC-3 USA, Israel Pulsotype 258C (n = 20) KPC-2, −11 SHV-12 Greece, Israel Pulsotype 258D (n = 5) KPC-2 SHV-12 USA, Puerto Rico ST1 (n = 2) VIM-1 Spain ST14 (n = 2) NDM-1 CTX-M-15, CMY-2 India ST15 (n = 2) OXA-48, −181 CTX-M-15 USA, India ST17 (n = 4) KPC-2, VIM-1, OXA-48 Greece, Turkey ST340 (n = 2) NDM-1 SHV-2, CTX-M-15 India ST418 (n = 2) KPC-2 USA ST43 (n = 3) OXA-181, VIM-5 SHV-2, CTX-M-15, CTX-M-3 India, Turkey ST478 (n = 2) IMP-26 CTX-M-15 Australia ST512 (n = 4) KPC-3 Israel, Columbia ST626 (n = 2) IMP-26 Phillipines Other STs (n = 13)a NDM-1, VIM-1, OXA-48, KPC-2, −3, and IMP-26 CTX-M-15, SHV-5, DHA-1, CMY-2, India, Greece, USA, Philippines ↵a Including ST101, ST20, ST231, ST271, ST278, ST29, ST336, ST34, ST391, ST437, ST572, ST676, and ST903; most of them (n = 9) were NDM-1 producers, with CTX-M-15 from India.
- Table 3
Characteristics of K. pneumoniae sequence types ST11, ST147, and ST258 and other STs that produce carbapenemases
Characteristic No. (%) with characteristic: P value ST11 (n = 11) ST147 (n = 23) ST258 (n = 38) Other STs (n = 38) Carbapenemase <0.001 NDM 6 (55) 9 (39) 0 11 (29) KPC 0 0 38 (100) 9 (24) OXA-48-like 5 (45) 2 (9) 0 6 (16) VIM 0 12 (52) 0 7 (18) IMP 0 0 0 5 (13) ESBL <0.001 CTX-M-15 5 (45) 11 (48) 0 16 (42) CTX-M-14 0 0 3 (8) 0 Other CTX-Ms 0 0 0 1 (3) SHV-12 0 4 (17) 26 (68) 2 (5) Other SHVs 0 1 (4) 0 5 (13) AmpC 0.233 DHA-1 1 (1) 1 (4) 0 1 (3) CMY-2 0 2 (9) 0 1 (3) Country of origin <0.001 India 6 (55) 11 (48) 0 14 (37) Philippines 0 0 0 3 (8) Australia 0 0 0 2 (5) USA 0 0 13 (34) 5 (13) Puerto Rico 0 0 1 (3) 0 Columbia 0 0 0 1 (3) Argentina 3 (27) 0 0 0 Spain 0 0 0 2 (5) Greece 0 11 (48) 18 (47) 6 (16) Italy 0 1 (4) 0 0 Turkey 2 (18) 0 0 2 (5) Israel 0 0 6 (16) 3 (8) Antimicrobial susceptibility <0.001 Col NS 1 (1) 3 (13) 20 (53) 9 (24) Tig NS 2 (18) 8 (35) 2 (5) 5 (13) PMQR determinants 0.016 aac(6′)-lb-cr 5 (45) 0 0 3 (8) aac(6′)-lb-cr with qnrB 1 (1) 11 (48) 0 11 (29) aac(6′)-lb-cr with qnrS 0 0 0 1 (3) qnrB 2 (18) 0 0 3 (8) qnrA 0 1 (4) 0 3 (8) qnrS 0 0 0 1 (3) 16S RNA methylases 0.014 armA 3 (27) 7 (30) 0 10 (26) armA with rmtB 0 0 0 2 (5) rmtC 0 4 (17) 0 1 (3) rmtB 0 0 1 (3) 1 (3) Virulence factors uge 9 (82) 23 (100) 38 (100) 37 (97) 0.022 wabG 11 (100) 23 (100) 38 (100) 38 (100) urea 11 (100) 23 (100) 38 (100) 38 (100) magA 0 0 0 0 mrkD 11 (100) 23 (100) 38 (100) 36 (95) 0.468 alls 0 2 (9) 0 5 (13) 0.084 kfuBC 0 0 0 11 (29) <0.001 rpmA 0 0 0 0 fimH 11 (100) 23 (100) 38 (100) 38 (100) Aerobactin 0 0 0 0
