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Experimental Therapeutics

Fosfomycin-Daptomycin and Other Fosfomycin Combinations as Alternative Therapies in Experimental Foreign-Body Infection by Methicillin-Resistant Staphylococcus aureus

C. Garrigós, O. Murillo, J. Lora-Tamayo, R. Verdaguer, F. Tubau, C. Cabellos, J. Cabo, J. Ariza
C. Garrigós
aLaboratory of Experimental Infection, Infectious Diseases Service, Hospital Universitari de Bellvitge, Barcelona, Spain
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O. Murillo
aLaboratory of Experimental Infection, Infectious Diseases Service, Hospital Universitari de Bellvitge, Barcelona, Spain
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J. Lora-Tamayo
aLaboratory of Experimental Infection, Infectious Diseases Service, Hospital Universitari de Bellvitge, Barcelona, Spain
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R. Verdaguer
bDepartments of Microbiology, Hospital Universitari de Bellvitge, Barcelona, Spain
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F. Tubau
bDepartments of Microbiology, Hospital Universitari de Bellvitge, Barcelona, Spain
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C. Cabellos
aLaboratory of Experimental Infection, Infectious Diseases Service, Hospital Universitari de Bellvitge, Barcelona, Spain
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J. Cabo
cOrthopaedic Surgery, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
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J. Ariza
aLaboratory of Experimental Infection, Infectious Diseases Service, Hospital Universitari de Bellvitge, Barcelona, Spain
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DOI: 10.1128/AAC.01570-12
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ABSTRACT

The efficacy of daptomycin, imipenem, or rifampin with fosfomycin was evaluated and compared with that of daptomycin-rifampin in a tissue cage model infection caused by methicillin-resistant Staphylococcus aureus (MRSA). Strain HUSA 304 was used. The study yielded the following results for MICs (in μg/ml): fosfomycin, 4; daptomycin, 1; imipenem, 0.25; and rifampin, 0.03. The study yielded the following results for minimum bactericidal concentration (MBC) (in μg/ml): fosfomycin, 8; daptomycin, 4; imipenem, 32; and rifampin, 0.5. Daptomycin-rifampin was confirmed as the most effective therapy against MRSA foreign-body infections. Fosfomycin combinations with high doses of daptomycin and rifampin were efficacious alternative therapies in this setting. Fosfomycin-imipenem was relatively ineffective and did not protect against resistance.

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Fosfomycin-Daptomycin and Other Fosfomycin Combinations as Alternative Therapies in Experimental Foreign-Body Infection by Methicillin-Resistant Staphylococcus aureus
C. Garrigós, O. Murillo, J. Lora-Tamayo, R. Verdaguer, F. Tubau, C. Cabellos, J. Cabo, J. Ariza
Antimicrobial Agents and Chemotherapy Dec 2012, 57 (1) 606-610; DOI: 10.1128/AAC.01570-12

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Fosfomycin-Daptomycin and Other Fosfomycin Combinations as Alternative Therapies in Experimental Foreign-Body Infection by Methicillin-Resistant Staphylococcus aureus
C. Garrigós, O. Murillo, J. Lora-Tamayo, R. Verdaguer, F. Tubau, C. Cabellos, J. Cabo, J. Ariza
Antimicrobial Agents and Chemotherapy Dec 2012, 57 (1) 606-610; DOI: 10.1128/AAC.01570-12
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