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Experimental Therapeutics

Multiscale Distribution and Bioaccumulation Analysis of Clofazimine Reveals a Massive Immune System-Mediated Xenobiotic Sequestration Response

Jason Baik, Kathleen A. Stringer, Gerta Mane, Gus R. Rosania
Jason Baik
aDepartment of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA
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Kathleen A. Stringer
bDepartment of Clinical, Social, and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA
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Gerta Mane
bDepartment of Clinical, Social, and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA
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Gus R. Rosania
aDepartment of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA
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DOI: 10.1128/AAC.01731-12
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Article Information

DOI 
https://doi.org/10.1128/AAC.01731-12
PubMed 
23263006

Published By 
American Society for Microbiology Journals
History 
  • Received August 21, 2012
  • Returned for modification October 6, 2012
  • Accepted December 8, 2012
  • Published online February 14, 2013.

Copyright & Usage 
Copyright © 2013, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (December 21, 2012).
  • You are viewing the most recent version of this article.

Author Information

  1. Jason Baika*,
  2. Kathleen A. Stringerb,
  3. Gerta Maneb and
  4. Gus R. Rosaniaa
  1. aDepartment of Pharmaceutical Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA
  2. bDepartment of Clinical, Social, and Administrative Sciences, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA
  • Address correspondence to Gus R. Rosania, grosania{at}umich.edu.
  • ↵* Present address: Jason Baik, Department of Bioengineering and Therapeutic Sciences, University of California—San Francisco, San Francisco, California, USA.

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Multiscale Distribution and Bioaccumulation Analysis of Clofazimine Reveals a Massive Immune System-Mediated Xenobiotic Sequestration Response
Jason Baik, Kathleen A. Stringer, Gerta Mane, Gus R. Rosania
Antimicrobial Agents and Chemotherapy Feb 2013, 57 (3) 1218-1230; DOI: 10.1128/AAC.01731-12

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Multiscale Distribution and Bioaccumulation Analysis of Clofazimine Reveals a Massive Immune System-Mediated Xenobiotic Sequestration Response
Jason Baik, Kathleen A. Stringer, Gerta Mane, Gus R. Rosania
Antimicrobial Agents and Chemotherapy Feb 2013, 57 (3) 1218-1230; DOI: 10.1128/AAC.01731-12
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