Low but Sufficient Anidulafungin Exposure in Critically Ill Patients

DOI: 10.1128/AAC.01607-13

Article Figures & Data

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FIG 1
Mean anidulafungin concentration-time curve with standard deviations.
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FIG 2
AUC versus MIC for individual patients with C. albicans (a) or C. glabrata (b) infection. The line represents the ratio of the AUC of the general patient population and the EUCAST MIC breakpoint of the Candida species.

TABLE 1

Patient characteristics

Characteristic	Median value (IQR^{^a})
Age (yr)	71 (60–75)
Weight (kg)	81 (72–102)
Height (cm)	175 (165–181)
BMI (kg/m²)	25.8 (23.4–36.4)
Total body water (liter)	41 (35–45)
Underlying condition (no. of patients)
Abdominal surgery	12
Pancreatitis	3
Infected prosthesis	2
Stomach perforation	1
Abdominal abscess	1
Pneumococcal sepsis	1
Diagnosis (no. of patients)
Candidemia	3
Candida peritonitis	13
Candidemia and candida peritonitis	4

TABLE 2

Disease severity scores and correlation with anidulafungin exposure

Score	Median (IQR)	Spearman correlation coefficient	P value
Apache II	14 (11–15)	0.078	0.743
LODS	5 (3–7)	0.317	0.174
MODS	4 (3–8)	0.374	0.105
ODIN	3 (2–4)	0.150	0.527
SAPS 2	41 (32–52)	0.202	0.394
SAPS 3	75 (63–78)	−0.094	0.695
SOFA	7 (4–9)	0.153	0.520