DOI: 10.1128/AAC.01607-13
Article Figures & Data
Figures
- FIG 1
Mean anidulafungin concentration-time curve with standard deviations.
- FIG 2
AUC versus MIC for individual patients with C. albicans (a) or C. glabrata (b) infection. The line represents the ratio of the AUC of the general patient population and the EUCAST MIC breakpoint of the Candida species.
Tables
- TABLE 1
Patient characteristics
Characteristic Median value (IQRa) Age (yr) 71 (60–75) Weight (kg) 81 (72–102) Height (cm) 175 (165–181) BMI (kg/m2) 25.8 (23.4–36.4) Total body water (liter) 41 (35–45) Underlying condition (no. of patients) Abdominal surgery 12 Pancreatitis 3 Infected prosthesis 2 Stomach perforation 1 Abdominal abscess 1 Pneumococcal sepsis 1 Diagnosis (no. of patients) Candidemia 3 Candida peritonitis 13 Candidemia and candida peritonitis 4 ↵a IQR, interquartile range.
- TABLE 2
Disease severity scores and correlation with anidulafungin exposure
Score Median (IQR) Spearman correlation coefficient P value Apache II 14 (11–15) 0.078 0.743 LODS 5 (3–7) 0.317 0.174 MODS 4 (3–8) 0.374 0.105 ODIN 3 (2–4) 0.150 0.527 SAPS 2 41 (32–52) 0.202 0.394 SAPS 3 75 (63–78) −0.094 0.695 SOFA 7 (4–9) 0.153 0.520
