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Clinical Therapeutics

Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Two-Day Regimen of Dihydroartemisinin-Piperaquine for Malaria Prevention Halted for Concern over Prolonged Corrected QT Interval

Jessica Manning, Pattaraporn Vanachayangkul, Chanthap Lon, Michele Spring, Mary So, Darapiseth Sea, Youry Se, Sok Somethy, Sut-Thang Phann, Soklyda Chann, Sabaithip Sriwichai, Nillawan Buathong, Worachet Kuntawunginn, Mashamon Mitprasat, Raveewan Siripokasupkul, Paktiya Teja-Isavadharm, Eugene Soh, Ans Timmermans, Charlotte Lanteri, Jaranit Kaewkungwal, Montida Auayporn, Douglas Tang, Char Meng Chour, Satharath Prom, Mark Haigney, Louis Cantilena, David Saunders
Jessica Manning
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Pattaraporn Vanachayangkul
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Chanthap Lon
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Michele Spring
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Mary So
cRoyal Cambodian Armed Forces, Phnom Penh, Cambodia
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Darapiseth Sea
bNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
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Youry Se
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Sok Somethy
cRoyal Cambodian Armed Forces, Phnom Penh, Cambodia
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Sut-Thang Phann
bNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
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Soklyda Chann
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Sabaithip Sriwichai
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Nillawan Buathong
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Worachet Kuntawunginn
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Mashamon Mitprasat
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Raveewan Siripokasupkul
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Paktiya Teja-Isavadharm
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Eugene Soh
dF. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Ans Timmermans
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Charlotte Lanteri
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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Jaranit Kaewkungwal
eCenter for Excellence in Bioinformatics (BIOPHICS), Mahidol University, Bangkok, Thailand
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Montida Auayporn
eCenter for Excellence in Bioinformatics (BIOPHICS), Mahidol University, Bangkok, Thailand
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Douglas Tang
fFast Track Biologics, Bethesda, Maryland, USA
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Char Meng Chour
bNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
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Satharath Prom
cRoyal Cambodian Armed Forces, Phnom Penh, Cambodia
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Mark Haigney
dF. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Louis Cantilena
dF. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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David Saunders
aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
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DOI: 10.1128/AAC.02667-14
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Article Information

DOI 
https://doi.org/10.1128/AAC.02667-14
PubMed 
25092702

Published By 
American Society for Microbiology Journals
History 
  • Received February 27, 2014
  • Returned for modification March 22, 2014
  • Accepted July 18, 2014
  • Published online September 15, 2014.

Copyright & Usage 
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (August 04, 2014).
  • You are viewing the most recent version of this article.

Author Information

  1. Jessica Manninga,
  2. Pattaraporn Vanachayangkula,
  3. Chanthap Lona,
  4. Michele Springa,
  5. Mary Soc,
  6. Darapiseth Seab,
  7. Youry Sea,
  8. Sok Somethyc,
  9. Sut-Thang Phannb,
  10. Soklyda Channa,
  11. Sabaithip Sriwichaia,
  12. Nillawan Buathonga,
  13. Worachet Kuntawunginna,
  14. Mashamon Mitprasata,
  15. Raveewan Siripokasupkula,
  16. Paktiya Teja-Isavadharma,
  17. Eugene Sohd,
  18. Ans Timmermansa,
  19. Charlotte Lanteria,
  20. Jaranit Kaewkungwale,
  21. Montida Auayporne,
  22. Douglas Tangf,
  23. Char Meng Chourb,
  24. Satharath Promc,
  25. Mark Haigneyd,
  26. Louis Cantilenad and
  27. David Saundersa
  1. aDepartment of Immunology and Medicine, Armed Forces Research Institute of Medical Science, Bangkok, Thailand
  2. bNational Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
  3. cRoyal Cambodian Armed Forces, Phnom Penh, Cambodia
  4. dF. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
  5. eCenter for Excellence in Bioinformatics (BIOPHICS), Mahidol University, Bangkok, Thailand
  6. fFast Track Biologics, Bethesda, Maryland, USA
  • Address correspondence to David Saunders, David.Saunders{at}afrims.org.
  • J.M. and P.V. contributed equally to this manuscript.

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Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Two-Day Regimen of Dihydroartemisinin-Piperaquine for Malaria Prevention Halted for Concern over Prolonged Corrected QT Interval
Jessica Manning, Pattaraporn Vanachayangkul, Chanthap Lon, Michele Spring, Mary So, Darapiseth Sea, Youry Se, Sok Somethy, Sut-Thang Phann, Soklyda Chann, Sabaithip Sriwichai, Nillawan Buathong, Worachet Kuntawunginn, Mashamon Mitprasat, Raveewan Siripokasupkul, Paktiya Teja-Isavadharm, Eugene Soh, Ans Timmermans, Charlotte Lanteri, Jaranit Kaewkungwal, Montida Auayporn, Douglas Tang, Char Meng Chour, Satharath Prom, Mark Haigney, Louis Cantilena, David Saunders
Antimicrobial Agents and Chemotherapy Sep 2014, 58 (10) 6056-6067; DOI: 10.1128/AAC.02667-14

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Randomized, Double-Blind, Placebo-Controlled Clinical Trial of a Two-Day Regimen of Dihydroartemisinin-Piperaquine for Malaria Prevention Halted for Concern over Prolonged Corrected QT Interval
Jessica Manning, Pattaraporn Vanachayangkul, Chanthap Lon, Michele Spring, Mary So, Darapiseth Sea, Youry Se, Sok Somethy, Sut-Thang Phann, Soklyda Chann, Sabaithip Sriwichai, Nillawan Buathong, Worachet Kuntawunginn, Mashamon Mitprasat, Raveewan Siripokasupkul, Paktiya Teja-Isavadharm, Eugene Soh, Ans Timmermans, Charlotte Lanteri, Jaranit Kaewkungwal, Montida Auayporn, Douglas Tang, Char Meng Chour, Satharath Prom, Mark Haigney, Louis Cantilena, David Saunders
Antimicrobial Agents and Chemotherapy Sep 2014, 58 (10) 6056-6067; DOI: 10.1128/AAC.02667-14
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