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Commentary

Towards a Paradigm Shift in the Treatment of Chronic Chagas Disease

R. Viotti, B. Alarcón de Noya, T. Araujo-Jorge, M. J. Grijalva, F. Guhl, M. C. López, J. M. Ramsey, I. Ribeiro, A. G. Schijman, S. Sosa-Estani, F. Torrico, J. Gascon
and on behalf of the Latin American Network for Chagas Disease, NHEPACHA
R. Viotti
Hospital Interzonal General de Agudos (HIGA) Eva Perón, Sección Chagas, Servicio de Cardiología, Buenos Aires, Argentina
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B. Alarcón de Noya
Instituto de Medicina Tropical, Universidad Central de Venezuela (IMT-UCV), Caracas, Venezuela
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T. Araujo-Jorge
Fundação Oswaldo Cruz—Instituto Oswaldo Cruz (FIOCRUZ-IOC), Programa Integrado de Doença de Chagas, Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Río de Janeiro, Brazil
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M. J. Grijalva
Centro de Investigación de Enfermedades Infecciosas de la Pontificia Universidad Católica del Ecuador (CIEI-PUCE), Quito, Ecuador, and Tropical Disease Institute, Ohio University (TDI-OU), Athens, Ohio, USA
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F. Guhl
Centro de Investigaciones en Microbiología y Parasitología Tropical, Universidad de los Andes (UA-CIMPAT), Bogotá, Colombia
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M. C. López
Instituto de Parasitología y Biomedicina Lopez-Neyra-Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), Granada, Spain
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J. M. Ramsey
Centro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública (CRISP-INSP), Tapachula, Chiapas, Mexico
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I. Ribeiro
Drugs for Neglected Diseases Initiative (DNDi), Geneva, Switzerland
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A. G. Schijman
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), CONICET, Buenos Aires, Argentina
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S. Sosa-Estani
Instituto Nacional de Parasitología Dr. Mario Fatala Chaben (INP)-ANLIS Dr. Carlos G. Malbran, Buenos Aires, Argentina
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F. Torrico
Universidad Mayor de San Simón (UMSS), Cochabamba, Bolivia
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J. Gascon
Barcelona Center for International Health Research (CRESIB), Hospital Clinic/IDIBAPS, Barcelona, Spain
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DOI: 10.1128/AAC.01662-13
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Article Information

DOI 
https://doi.org/10.1128/AAC.01662-13
PubMed 
24247135

Published By 
American Society for Microbiology Journals
History 
  • Published online January 27, 2014.

Copyright & Usage 
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Article Versions

  • Accepted Manuscript version (November 18, 2013).
  • You are viewing the most recent version of this article.

Author Information

  1. R. Viottia,
  2. B. Alarcón de Noyab,
  3. T. Araujo-Jorgec,
  4. M. J. Grijalvad,
  5. F. Guhle,
  6. M. C. Lópezf,
  7. J. M. Ramseyg,
  8. I. Ribeiroh,
  9. A. G. Schijmani,
  10. S. Sosa-Estanij,
  11. F. Torricok and
  12. J. Gasconl
  13. on behalf of the Latin American Network for Chagas Disease, NHEPACHA
  1. aHospital Interzonal General de Agudos (HIGA) Eva Perón, Sección Chagas, Servicio de Cardiología, Buenos Aires, Argentina
  2. bInstituto de Medicina Tropical, Universidad Central de Venezuela (IMT-UCV), Caracas, Venezuela
  3. cFundação Oswaldo Cruz—Instituto Oswaldo Cruz (FIOCRUZ-IOC), Programa Integrado de Doença de Chagas, Laboratório de Inovações em Terapias, Ensino e Bioprodutos, Río de Janeiro, Brazil
  4. dCentro de Investigación de Enfermedades Infecciosas de la Pontificia Universidad Católica del Ecuador (CIEI-PUCE), Quito, Ecuador, and Tropical Disease Institute, Ohio University (TDI-OU), Athens, Ohio, USA
  5. eCentro de Investigaciones en Microbiología y Parasitología Tropical, Universidad de los Andes (UA-CIMPAT), Bogotá, Colombia
  6. fInstituto de Parasitología y Biomedicina Lopez-Neyra-Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), Granada, Spain
  7. gCentro Regional de Investigación en Salud Pública, Instituto Nacional de Salud Pública (CRISP-INSP), Tapachula, Chiapas, Mexico
  8. hDrugs for Neglected Diseases Initiative (DNDi), Geneva, Switzerland
  9. iInstituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), CONICET, Buenos Aires, Argentina
  10. jInstituto Nacional de Parasitología Dr. Mario Fatala Chaben (INP)-ANLIS Dr. Carlos G. Malbran, Buenos Aires, Argentina
  11. kUniversidad Mayor de San Simón (UMSS), Cochabamba, Bolivia
  12. lBarcelona Center for International Health Research (CRESIB), Hospital Clinic/IDIBAPS, Barcelona, Spain
  • Address correspondence to R. Viotti, rviotti{at}arnet.com.ar.
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Towards a Paradigm Shift in the Treatment of Chronic Chagas Disease
R. Viotti, B. Alarcón de Noya, T. Araujo-Jorge, M. J. Grijalva, F. Guhl, M. C. López, J. M. Ramsey, I. Ribeiro, A. G. Schijman, S. Sosa-Estani, F. Torrico, J. Gascon on behalf of the Latin American Network for Chagas Disease, NHEPACHA
Antimicrobial Agents and Chemotherapy Jan 2014, 58 (2) 635-639; DOI: 10.1128/AAC.01662-13

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Towards a Paradigm Shift in the Treatment of Chronic Chagas Disease
R. Viotti, B. Alarcón de Noya, T. Araujo-Jorge, M. J. Grijalva, F. Guhl, M. C. López, J. M. Ramsey, I. Ribeiro, A. G. Schijman, S. Sosa-Estani, F. Torrico, J. Gascon on behalf of the Latin American Network for Chagas Disease, NHEPACHA
Antimicrobial Agents and Chemotherapy Jan 2014, 58 (2) 635-639; DOI: 10.1128/AAC.01662-13
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  • Top
  • Article
    • ABSTRACT
    • TEXT
    • PATHOGENESIS OF CHRONIC CHAGAS DISEASE: CHRONIC PERSISTENCE OF THE PARASITE?
    • WHAT IS CONSIDERED EFFICACY: A LOWER PARASITE BURDEN OR PARASITE CLEARANCE?
    • TREATMENT MONITORING
    • ADVERSE EFFECTS OF ANTIPARASITIC TREATMENT
    • CONCLUSIONS
    • ACKNOWLEDGMENT
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

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