DOI: 10.1128/AAC.02047-13
Article Figures & Data
Tables
- TABLE 1
Features of the carbapenem-resistant isolates and patient characteristics
Patient/strain no. Date of isolation (mo/day/yr) Isolate Site of isolationa Carbapenemase produced Associated β-lactamase(s) 16S rRNA methylase Sequence type Hospitalization unitb Patient age 1 01/25/2013 K. pneumoniae Urine NDM-1 CTX-M-15 + CMY-6 + SHV-1 RmtC ST15 Internal medicine 60 yr 2 02/13/2013 K. pneumoniae ETA OXA-48 CTX-M-15 + OXA-1 + TEM-1 + SHV-1 None ST101 ICU 31 yr 3 02/25/2013 K. pneumoniae ETA OXA-48 CTX-M-15 + OXA-1 + TEM-1 + SHV-1 None ST101 ICU 56 yr 4 03/09/2013 K. pneumoniae Body fluid OXA-48 CTX-M-15 + OXA-1 + TEM-1 + SHV-1 None ST101 Orthopedics 73 yr 5 03/13/2013 E. coli Body fluid OXA-48 CTX-M-3 + OXA-1 + TEM-1 None NDc Gynecology 65 yr 6 03/30/2013 E. cloacae ETA NDM-1 CTX-M-15 + OXA-1 RmtC ND NICU Newborn 7 04/02/2013 E. cloacae Urine NDM-1 CTX-M-15 + OXA-1 RmtC ND NICU 3 mo 8 04/03/2013 E. cloacae Urine NDM-1 CTX-M-15 + OXA-1 RmtC ND NICU 4 mo 9 04/03/2013 E. cloacae Rectal swab NDM-1 CTX-M-15 + OXA-1 RmtC ND NICU Newborn 10 04/06/2013 E. cloacae Urine NDM-1 CTX-M-15 + OXA-1 RmtC ND NICU Newborn 11 04/09/2013 E. cloacae Nasal swab NDM-1 CTX-M-15 + OXA-1 RmtC ND NICU 3 mo 12 04/10/2013 E. coli Urine OXA-48 CTX-M-15 None ND Pediatrics 7 yr 13 04/16/2013 E. cloacae Rectal swab NDM-1 CTX-M-15 + OXA-1 RmtC ND NICU 1 mo 14 04/21/2013 E. cloacae Rectal swab NDM-1 CTX-M-15 + OXA-1 RmtC ND NICU 4 mo 15 04/24/2013 K. pneumoniae Urine OXA-48 CTX-M-15 + OXA-1 + TEM-1 + SHV-1 None ST101 ICU 12 yr 16 04/04/2013 K. pneumoniae Rectal swab NDM-1 CTX-M-3 + SHV-27 RmtC ST1059 NICU Newborn 17 04/04/2013 K. pneumoniae Rectal swab NDM-1 OXA-1 + SHV-1 RmtC ST45 NICU Newborn 18 04/04/2013 K. pneumoniae Rectal swab NDM-1 OXA-1 + SHV-27 RmtC ST278 NICU Newborn 19 04/29/2013 K. pneumoniae Urine OXA-48 CTX-M-15 + OXA-1 + TEM-1 + SHV-1 None ST101 Neurosurgery 12 yr 20 04/30/2013 K. pneumoniae BAL fluid OXA-48 CTX-M-15 + OXA-1 + TEM-1 + SHV-1 None ST101 Pneumology 60 yr 21 04/30/2013 K. pneumoniae Skin tissue KPC-2 OXA-9 + SHV-1 + TEM-1 None ST307 Plastic surgery 64 yr 22 04/30/2013 K. pneumoniae Urine KPC-2 OXA-9 + SHV-1 + TEM-1 None ST307 Plastic surgery 12 yr - TABLE 2
MICs of carbapenems and coresistance to non-β-lactam antibiotics
Patient/strain no. Isolate Carbapenemase produced MIC (μg/ml) of carbapenemsa Coresistancesb IMP MER ERT 1 K. pneumoniae NDM-1 2 4 16 TET SUL RIF AMK GEN TOB 2 K. pneumoniae OXA-48 1 1 4 SUL AMK GEN TOB FQ FOS 3 K. pneumoniae OXA-48 0.5 2 8 TET GEN TOB FQ CHL 4 K. pneumoniae OXA-48 0.5 2 8 TET GEN TOB FQ CHL 5 E. coli OXA-48 0.5 0.25 0.5 SUL RIF FOS 6 E. cloacae NDM-1 8 4 8 TET SUL RIF AMK GEN TOB 7 E. cloacae NDM-1 8 4 8 TET SUL RIF AMK GEN TOB 8 E. cloacae NDM-1 8 4 8 TET SUL RIF AMK GEN TOB 9 E. cloacae NDM-1 8 4 8 TET SUL RIF AMK GEN TOB 10 E. cloacae NDM-1 8 4 8 TET SUL RIF AMK GEN TOB 11 E. cloacae NDM-1 8 4 8 TET SUL RIF AMK GEN TOB 12 E. coli OXA-48 0.5 0.25 0.5 SUL RIF FOS 13 E. cloacae NDM-1 8 4 8 TET SUL RIF AMK GEN TOB 14 E. cloacae NDM-1 8 4 8 TET SUL RIF AMK GEN TOB 15 K. pneumoniae OXA-48 1 4 8 TET SUL RIF GEN TOB FQ 16 K. pneumoniae NDM-1 4 4 8 TET SUL RIF AMK GEN TOB COL 17 K. pneumoniae NDM-1 4 4 4 TET SUL RIF AMK GEN TOB 18 K. pneumoniae NDM-1 4 2 8 TET SUL RIF AMK GEN TOB 19 K. pneumoniae OXA-48 1 4 16 TET RIF GEN TOB FOS COL 20 K. pneumoniae OXA-48 8 8 16 TET SUL GEN TOB FQ CHL FOS 21 K. pneumoniae KPC-2 2 4 8 RIF FQ FOS 22 K. pneumoniae KPC-2 2 4 8 RIF FQ FOS ↵a IMP, imipenem; MER, meropenem; ERT, ertapenem.
↵b TET, tetracycline; SUL, sulfonamides; RIF, rifampin; AMK, amikacin; GEN, gentamicin; TOB, tobramycin; FQ, fluoroquinolones (ciprofloxacin and ofloxacin); COL, colistin (indicated when the MIC was not <0.5 μg/ml); CHL, chloramphenicol; FOS, fosfomycin.
