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Epidemiology and Surveillance

Decreased Ceftriaxone Susceptibility in Emerging (35B and 6C) and Persisting (19A) Streptococcus pneumoniae Serotypes in the United States, 2011-2012: Ceftaroline Remains Active In Vitro among β-Lactam Agents

Rodrigo E. Mendes, Donald Biek, Ian A. Critchley, David J. Farrell, Helio S. Sader, Ronald N. Jones
Rodrigo E. Mendes
aJMI Laboratories, North Liberty, Iowa, USA
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Donald Biek
bCerexa, Inc., Oakland, California, USA
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Ian A. Critchley
bCerexa, Inc., Oakland, California, USA
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David J. Farrell
aJMI Laboratories, North Liberty, Iowa, USA
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Helio S. Sader
aJMI Laboratories, North Liberty, Iowa, USA
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Ronald N. Jones
aJMI Laboratories, North Liberty, Iowa, USA
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DOI: 10.1128/AAC.02976-14
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ABSTRACT

Totals of 8.7% (103/1,190) and 21.0% (249/1,190) of the Streptococcus pneumoniae isolates recovered from specimens collected in the United States during the 2011-2012 AWARE (Assessing Worldwide Antimicrobial Resistance Evaluation) Surveillance Program were ceftriaxone nonsusceptible according to the CLSI (≤1 μg/ml for susceptible) and EUCAST (≤0.5 μg/ml for susceptible) criteria, respectively. Decreased susceptibility to ceftriaxone (MIC, 1 μg/ml) was frequently observed among serotypes 19A (51.4%; 128/249) and 35B (29.7%; 74/249), which were most often observed in the East South Central and South Atlantic U.S. Census regions. Ceftaroline (MIC50/90, 0.12/0.25 μg/ml) remained active (≥96.8% susceptible) when tested against these less susceptible isolates.

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Decreased Ceftriaxone Susceptibility in Emerging (35B and 6C) and Persisting (19A) Streptococcus pneumoniae Serotypes in the United States, 2011-2012: Ceftaroline Remains Active In Vitro among β-Lactam Agents
Rodrigo E. Mendes, Donald Biek, Ian A. Critchley, David J. Farrell, Helio S. Sader, Ronald N. Jones
Antimicrobial Agents and Chemotherapy Jul 2014, 58 (8) 4923-4927; DOI: 10.1128/AAC.02976-14

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Decreased Ceftriaxone Susceptibility in Emerging (35B and 6C) and Persisting (19A) Streptococcus pneumoniae Serotypes in the United States, 2011-2012: Ceftaroline Remains Active In Vitro among β-Lactam Agents
Rodrigo E. Mendes, Donald Biek, Ian A. Critchley, David J. Farrell, Helio S. Sader, Ronald N. Jones
Antimicrobial Agents and Chemotherapy Jul 2014, 58 (8) 4923-4927; DOI: 10.1128/AAC.02976-14
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