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Epidemiology and Surveillance

Population Structure of KPC-Producing Klebsiella pneumoniae Isolates from Midwestern U.S. Hospitals

Meredith S. Wright, Federico Perez, Lauren Brinkac, Michael R. Jacobs, Keith Kaye, Eric Cober, David van Duin, Steven H. Marshall, Andrea M. Hujer, Susan D. Rudin, Kristine M. Hujer, Robert A. Bonomo, Mark D. Adams
Meredith S. Wright
aJ. Craig Venter Institute, La Jolla, California, USA
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Federico Perez
bResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
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Lauren Brinkac
aJ. Craig Venter Institute, La Jolla, California, USA
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Michael R. Jacobs
cDepartment of Pathology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA
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Keith Kaye
dDetroit Medical Center, Detroit, Michigan, USA
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Eric Cober
eInfectious Diseases Department, Cleveland Clinic, Cleveland, Ohio, USA
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David van Duin
fDivision of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA
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Steven H. Marshall
bResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
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Andrea M. Hujer
bResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
gDepartment of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
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Susan D. Rudin
bResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
gDepartment of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
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Kristine M. Hujer
bResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
gDepartment of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
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Robert A. Bonomo
bResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
gDepartment of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
hDepartment of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA
iDepartment of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA
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Mark D. Adams
aJ. Craig Venter Institute, La Jolla, California, USA
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DOI: 10.1128/AAC.00125-14
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This article has a correction. Please see:

  • Erratum for Wright et al., Population Structure of KPC-Producing Klebsiella pneumoniae Isolates from Midwestern U.S. Hospitals
    - September 15, 2014

ABSTRACT

Genome sequencing of carbapenem-resistant Klebsiella pneumoniae isolates from regional U.S. hospitals was used to characterize strain diversity and the blaKPC genetic context. A phylogeny based on core single-nucleotide variants (SNVs) supports a division of sequence type 258 (ST258) into two distinct groups. The primary differences between the groups are in the capsular polysaccharide locus (cps) and their plasmid contents. A strict association between clade and KPC variant was found. The blaKPC gene was found on variants of two plasmid backbones. This study indicates that highly similar K. pneumoniae subpopulations coexist within the same hospitals over time.

FOOTNOTES

    • Received 20 January 2014.
    • Returned for modification 23 February 2014.
    • Accepted 1 June 2014.
    • Accepted manuscript posted online 9 June 2014.
  • Supplemental material for this article may be found at http://dx.doi.org/10.1128/AAC.00125-14.

  • Copyright © 2014, American Society for Microbiology. All Rights Reserved.
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Population Structure of KPC-Producing Klebsiella pneumoniae Isolates from Midwestern U.S. Hospitals
Meredith S. Wright, Federico Perez, Lauren Brinkac, Michael R. Jacobs, Keith Kaye, Eric Cober, David van Duin, Steven H. Marshall, Andrea M. Hujer, Susan D. Rudin, Kristine M. Hujer, Robert A. Bonomo, Mark D. Adams
Antimicrobial Agents and Chemotherapy Jul 2014, 58 (8) 4961-4965; DOI: 10.1128/AAC.00125-14

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Population Structure of KPC-Producing Klebsiella pneumoniae Isolates from Midwestern U.S. Hospitals
Meredith S. Wright, Federico Perez, Lauren Brinkac, Michael R. Jacobs, Keith Kaye, Eric Cober, David van Duin, Steven H. Marshall, Andrea M. Hujer, Susan D. Rudin, Kristine M. Hujer, Robert A. Bonomo, Mark D. Adams
Antimicrobial Agents and Chemotherapy Jul 2014, 58 (8) 4961-4965; DOI: 10.1128/AAC.00125-14
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